A5063188212- Health Systems, Economic Evaluations, Quality of Life
- Genomics and Rare Diseases
- Genetic factors in colorectal cancer
- Antibiotic Use and Resistance
- BRCA gene mutations in cancer
- Pharmaceutical Economics and Policy
- Cancer Genomics and Diagnostics
- Prenatal Screening and Diagnostics
- Genomic variations and chromosomal abnormalities
- Insurance, Mortality, Demography, Risk Management
- Inflammatory Bowel Disease
- Patient Satisfaction in Healthcare
- Economic and Environmental Valuation
- Healthcare Policy and Management
- Child and Animal Learning Development
- Biomedical Ethics and Regulation
- Pharmacovigilance and Adverse Drug Reactions
- Ethics in Clinical Research
- Cystic Fibrosis Research Advances
- Microscopic Colitis
- CRISPR and Genetic Engineering
- Statistical Methods in Clinical Trials
- Colorectal Cancer Screening and Detection
- Healthcare Systems and Technology
- Clostridium difficile and Clostridium perfringens research
National Institute for Health Research
2018-2025
Queen Mary University of London
2024-2025
University of Oxford
2015-2024
NIHR Biomedical Research Centre at The Royal Marsden and the ICR
2019-2024
NIHR Oxford Musculoskeletal Biomedical Research Centre
2023
University of California, San Francisco
2023
Oxford BioMedica (United Kingdom)
2021-2022
Oxford Biomedical Research
2022
John Radcliffe Hospital
2020-2022
Public Health England
2020-2022
The U.K. 100,000 Genomes Project is in the process of investigating role genome sequencing patients with undiagnosed rare diseases after usual care and alignment this research health implementation National Health Service. Other parts project focus on cancer infection.
The translation of genome sequencing into routine health care has been slow, partly because concerns about affordability. aspirational cost a is $1000, but there little evidence to support this estimate. We estimate the using in clinical patients with cancer or rare diseases.We performed microcosting study Illumina-based UK National Health Service laboratory processing 399 samples/year. Cost data were collected for all steps pathway, including bioinformatics analysis and reporting results....
Background Lung cancer is the second most common in incidence and leading cause of deaths worldwide.Meanwhile, lung screening with low-dose CT can reduce mortality.The UK National Screening Committee recommended targeted on Sept 29, 2022, asked for more modelling work to be done help refine recommendation.This study aims develop validate a risk prediction model-the CanPredict (lung) model-for compare model performance against seven other models.Methods For this retrospective,...
Genomic testing is becoming routine for diagnosing rare childhood genetic disease. Evidence underlying sustainable implementation limited, focusing on short-term endpoints such as diagnostic yield, unable to fully characterize patient and family valued outcomes. Although genomic widely available, evidentiary outcomes uncertainty persist key challenges implementation. We examine whether the current evidence base reflects public tolerance genomics diagnose conducted focus groups with general...
Journal Article Volvulus of the stomach Get access James Buchanan Resident Surgical Officer St. James' Hospital, London Search for other works by this author on: Oxford Academic Google Scholar British Surgery, Volume 18, Issue 69, July 1930, Pages 99–112, https://doi.org/10.1002/bjs.1800186914 Published: 06 December 2005
Beck's content specificity hypothesis predicts distinct cognitive within specific psychological disorders. We evaluated whether the third component of "cognitive triad", negative view future (hopelessness), would be related 4 weeks later to depressive symptoms, but not anxiety. University student participants (83 females, 71 males) were tested on Beck Depression Inventory and Anxiety at two points in time, separated by weeks. The Hopelessness Scale was administered time 1 a Life Events 2....
Bacteria are becoming increasingly resistant to antibiotics, reducing our ability treat infections and threatening undermine modern health care. Optimising antibiotic use is a key element in tackling the problem. Traditional economic evaluation methods do not capture many of benefits from improved potential impact on resistance. Not capturing these major obstacle optimising use, as it fails incentivise development interventions optimise antibiotics preserve their effectiveness (stewardship...
First-line treatments for unexplained infertility traditionally include clomifene citrate (CC) or unstimulated intrauterine insemination (IUI). A recently published randomized controlled trial considered the effectiveness of CC and IUI in patients with found that neither treatment offered a superior live birth rate when compared expectant management (EM). This paper reports economic evaluation conducted alongside this order to assess whether health care providers are gaining value money...
Inflammatory Bowel Disease (which includes Crohn's and Ulcerative Colitis), is a chronic condition characterised by substantial morbidity. patients are considered expensive to manage, hence accurate estimates of care costs crucial help healthcare providers plan clinical management. The aim this study estimate the cost for Colitis in United Kingdom Western mainland Europe.Decision models were built simulate natural disease history Colitis, informed European pathways. A provider perspective...
Genomic information could help to reduce the morbidity effects of inappropriate treatment decisions in many disease areas, particular cancer. However, evidence benefits that patients derive from genomic testing is limited. This study evaluated patient preferences for context chronic lymphocytic leukaemia (CLL). We used a discrete choice experiment (DCE) survey assess CLL UK testing. The presented with 16 questions which they had choose between two possible test scenarios. Tests these...