A5065710640- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- Hormonal and reproductive studies
- Molecular Biology Techniques and Applications
- Genital Health and Disease
- Radiomics and Machine Learning in Medical Imaging
- Metabolism, Diabetes, and Cancer
- Ferroptosis and cancer prognosis
- MRI in cancer diagnosis
- Cardiovascular Disease and Adiposity
- Sexual Differentiation and Disorders
- Urological Disorders and Treatments
- Urinary Bladder and Prostate Research
- Cervical Cancer and HPV Research
- Pelvic and Acetabular Injuries
- Medical Practices and Rehabilitation
- Systemic Sclerosis and Related Diseases
- Medical and Health Sciences Research
- Vaccine Coverage and Hesitancy
- Kidney Stones and Urolithiasis Treatments
- Phonocardiography and Auscultation Techniques
- COVID-19 epidemiological studies
Klinikum Braunschweig
2015-2025
Medizinische Hochschule Brandenburg Theodor Fontane
2024-2025
Mayo Clinic
2022
Sulzer (Switzerland)
2017
University Hospital Leipzig
2015
While statins have demonstrated a variety of antineoplastic effects in preclinical studies, several retrospective clinical studies and observational not shown consistent chemopreventive benefit against prostate cancer (PCa). Therefore, this population-based cohort study, we examined the association statin intake on specific antigen (PSA) values risk development PCa.
Objective To assess the value of a positive family history ( FH ) as risk factor for prostate cancer incidence and grade among men undergoing organised prostate‐specific antigen PSA screening in population‐based study. Subjects Methods The study cohort comprised all attendees Swiss arm European Randomised Study Screening Prostate Cancer ERSPC with systematic level tests every 4 years. Men reporting first‐degree relative(s) diagnosed were considered to have . Biopsy was exclusively triggered...
<b><i>Objective:</i></b> To examine and predicting stone-free rates (SFRs) after minimally invasive-percutaneous nephrolithotomy (mini-PNL) based on computed tomography (CT), instead of X-ray or ultrasound control. <b><i>Patients Methods:</i></b> We identified 146 mini-PNL patients with pre- postoperative CT scans. Patient stone characteristics were assessed. Stone-free status was defined as ≤3 mm residual fragment according to postsurgery...
Abstract Background To evaluate antibiotic prophylaxis in transrectal prostate biopsies due to the recommendation of European Medicines Agency (EMA): We describe our single center experience switching from ciprofloxacin fosfomycin trometamol (FMT) alone and an augmented combining trimethoprim/sulfamethoxazole (TMP/SMX). Methods Between 01/2019 12/2020 we compared three different regimes. The primary endpoint was clinical diagnosis infection within 4 weeks after biopsy. enrolled 822 men, 398...
The role of elastography in patients initially and at repeat prostate biopsy is still indeterminate. existing literature sparse controversial.We studied who underwent based systematic between October 2009 February 2015 Braunschweig Prostate Cancer Center. Patients were separated according to first vs setting. Each sextant was considered an individual case. sensitivity, specificity, positive negative predictive values, accuracy predict results analyzed. 95% CIs determined by bootstrapping...
Recent studies indicate frequent early PSA retesting unrelated of men's baseline PSA, which increases the harms detection especially among men with low PSA. The current study investigates PCa incidence <1.0 ng ml−1 in order to adjust retest intervals for more targeted detection. Between 1998 and 2012, 2,416 were prospectively observed. Primary endpoint was diagnosis. Negative predictive value (NPV) number needed screen (NNS) detect one calculated. During a median follow-up time 12.1 years,...
Abstract Holmium laser enucleation of the prostate (HoLEP) is a valid treatment option to relieve bladder outlet obstruction in patients with large volumes (PV). Its efficacy, tolerability, and safety are comparable ones other treatments resection techniques. However, efficacy HoLEP have not been compared between without preoperative urinary retention. We included 350 (mean age 71.2 years) who had undergone due lower tract symptoms (LUTS) or retention caused by prostatic hyperplasia....
The objective of this study is to evaluate prostate-specific membrane antigen positron emission tomography-computed tomography (PSMA PET/CT)-based primary staging in exclusively D'Amico intermediate-risk prostate cancer (PCa) patients.We relied on the Braunschweig institutional database and retrospectively identified PCa patients who were administered 68Ga-PSMA PET/CT-based prior consecutive radical prostatectomy extended lymph node dissection. Sensitivity, specificity, positive predictive...
Penile cancer (PeCa) is an orphan disease in European countries. The current guidelines are predominantly based on retrospective studies with a low level of evidence. In our study, we aimed to identify predictors for guideline-conform treatment and hypothesize that reference centers PeCa physicians' experience promote guideline compliance therefore correct local tumor therapy. This study part the PROspective Cancer Study (E-PROPS), international collaboration group evaluating therapeutic...
You have accessJournal of UrologyProstate Cancer: Detection & Screening (III)1 Apr 20131934 PROSTATE SPECIFIC ANTIGEN (PSA)-PYRAMID IN MEN WITH LOW RANGE PSA: CANCER INCIDENCE AND MORTALITY - A PLEA FOR RISK-BASED SCREENING STRATEGY THE EUROPEAN RANDOMIZED STUDY OF (ERSPC), AARAU Marco Randazzo, Daniel Seiler, Josef Beatrice, Martin Baumgartner, Andreas Huber, Rainer Grobholz, Lukas Manka, Sascha Ahyai, Felix Chun, Franz Recker, and Maciej Kwiatkowski RandazzoMarco Randazzo Aarau,...
<b><i>Objective:</i></b> The aim of this study was to examine elastography-based prostate biopsy in cancer (PCa) patients under active surveillance. <b><i>Patients and Methods:</i></b> We relied on PCa who opted for surveillance underwent elastography targeted systematic follow-up at the Braunschweig Prostate Cancer Center between October 2009 February 2015. Each sextant considered as an individual case. Sensitivity, specificity, positive...
<b><i>Introduction:</i></b> Very low-risk prostate cancer (PCa) is being increasingly managed by active surveillance (AS). Our aim was to assess the influence of origin diagnosis on PCa characteristics and treatment rates among men with very in our prospective AS cohort. <b><i>Methods: </i></b>Overall, 191 fulfilling Epstein-criteria underwent protocol-based AS. These originated either from population-based screening program (P-AS) or were...
You have accessJournal of UrologyProstate Cancer: Detection and Screening VII1 Apr 2015MP86-07 ASSOCIATION OF METFORMIN USE WITH PROSTATE CANCER INCIDENCE IN A PROSPECTIVE SCREENING TRIAL (ERSPC AARAU) Marco Randazzo, Thomas Hermanns, Cedric Poyet, Josef Beatrice, Andreas Huber, Rainer Grobholz, Lukas Manka, Stephen Wyler, Franz Recker, Maciej Kwiatkowski RandazzoMarco Randazzo More articles by this author , HermannsThomas Hermanns PoyetCedric Poyet BeatriceJosef Beatrice HuberAndreas Huber...
The debate of prostate cancer (PCa) screening has been shaped over decades. There is a plethora articles in the literature supporting as well declining prostate-specific antigen (PSA) screening. Does decrease PCa mortality? With long-term results European Randomized Study Screening for Prostate (ERSPC) answer clearly YES. It moves! However, medicine there are no benefits without any harm and thus, to be performed targeted smart way-or other words-in risk-adapted fashion when compared with...