A5068214093- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Tissue Engineering and Regenerative Medicine
- Urological Disorders and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Urinary Bladder and Prostate Research
- Urologic and reproductive health conditions
- Bladder and Urothelial Cancer Treatments
- Pelvic floor disorders treatments
- Cancer, Lipids, and Metabolism
- Muscle Physiology and Disorders
- MRI in cancer diagnosis
- Radiopharmaceutical Chemistry and Applications
- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Mesenchymal stem cell research
- Radiomics and Machine Learning in Medical Imaging
- Testicular diseases and treatments
- Reconstructive Surgery and Microvascular Techniques
- Advanced MRI Techniques and Applications
- Urinary Tract Infections Management
- Autophagy in Disease and Therapy
- Sexual function and dysfunction studies
- Sexual Differentiation and Disorders
- Advanced Neuroimaging Techniques and Applications
University Hospital of Zurich
2016-2025
University of Zurich
2016-2025
Johns Hopkins University
2021
Klinik und Poliklinik für Urologie
2014-2020
See-Spital
2016-2020
GTx (United States)
2019
University Children's Hospital Zurich
2019
John Wiley & Sons (United States)
2018
Swiss Integrative Center for Human Health
2016-2018
Hudson Institute
2018
Effective hemostatic dressings that are compatible with tissues needed. Keratins a class of biomaterials can be derived by extraction proteins from human hair. We have recently discovered keratin characteristics and hypothesize hydrogel having the ability to absorb fluid bind cells may an effective hemostat. The goal this study was test evaluate it compared current hemostats. Thirty-two New Zealand white rabbits received lethal liver injury. Eight animals each were assigned negative control,...
<i>Introduction:</i> Bipolar vessel-sealing devices (VSDs) have advantages in urological surgeries (less hemorrhage, shorter operating time). However, these instruments can cause thermal injuries, which result neural damage and necrosis. The objectives of this study were to establish a reproducible vitro model for standardized assessment electrosurgical evaluate whether optimized placement surgical reduce the spread. <i>Methods:</i> We evaluated spread two VSDs using...
Abstract Planar in vitro models have been invaluable tools to identify the mechanical basis of wound closure. Although these may recapitulate closure dynamics epithelial cell sheets, they fail capture how a wounded fibrous tissue rebuilds its 3D architecture. Here we develop biomimetic model for soft repair and demonstrate that fibroblasts ensconced collagen matrix rapidly close microsurgically induced defects within 24 h. Traction force microscopy time-lapse imaging reveal gaps begins with...
Background Recent studies have reported the additive value of combined gallium 68 (68Ga)-labeled Glu-urea-Lys (Ahx)-HBED-CC ligand targeting prostate-specific membrane antigen (PSMA) (hereafter called 68Ga-PSMA-11) PET/MRI for detection and localization primary prostate cancer compared with multiparametric MRI. Purpose To compare diagnostic accuracy interrater agreement MRI 68Ga-PSMA-11 extracapsular extension (ECE) seminal vesicle infiltration (SVI) in patients cancer. Materials Methods...
The intense accumulation of prostate-specific membrane antigen (PSMA) radioligands in salivary glands is still not well understood. It concern for therapeutic applications PSMA radioligands, because radiation will damage these glands. A better understanding the uptake mechanism is, therefore, crucial to find solutions reduce toxicity. aim this study was investigate whether PSMA-targeting submandibular (SMGs) can be explained with expression levels using autoradiography (ARG) and...
Prostate-specific membrane antigen (PSMA-) PET has become a promising tool in staging and restaging of prostate carcinoma (PCa). However, specific primary tumour features might impact accuracy PSMA-PET for PCa detection. We investigated histopathological parameters immunohistochemical PSMA expression patterns on radical prostatectomy (RPE) specimens correlated them to the corresponding 68Ga-PSMA-11-PET examinations.RPE 62 patients with preoperative between 2016 2018 were analysed. WHO/ISUP...
Abstract Purpose Ultrasound-guided biopsy (US biopsy) with 10–12 cores has a suboptimal sensitivity for clinically significant prostate cancer (sigPCa). If US is negative, magnetic resonance imaging (MRI)–guided recommended, despite low specificity lesions score 3–5 on Prostate Imaging Reporting and Data System (PIRADS). Screening guidance using an modality high accuracy could reduce the number of unnecessary biopsies, reducing side effects. The aim this study was to assess performance...
To investigate inter-reader agreement, and diagnostic performance of the Prostate Imaging after Focal Ablation (PI-FAB) score applied to multiparametric MRI (mpMRI) in patients who underwent focal high-intensity focused ultrasound (HIFU) therapy for localized prostate cancer.
Abstract Purpose To compare the safety and efficacy of Thulium Fiber Laser (TFL) using either manufacturer presets (MP) or individualized (IP) in ureteroscopy. Methods Multi-institutional, retrospective analysis on first patients treated with SOLTIVE ® Premium (Olympus Medical Systems ) TFL Switzerland 2020. MP were used at University Hospital Geneva, while IP Zurich. Patient demographics, stone characteristics, procedural details collected. Primary outcome was postoperative ureteral...
While statins have demonstrated a variety of antineoplastic effects in preclinical studies, several retrospective clinical studies and observational not shown consistent chemopreventive benefit against prostate cancer (PCa). Therefore, this population-based cohort study, we examined the association statin intake on specific antigen (PSA) values risk development PCa.
Various reconstructive procedures have been attempted to restore a cosmetically acceptable phallus that would allow normal reproductive, sexual, and urinary function in patients requiring penile reconstruction. However, these are limited by shortage of native tissue. We previously demonstrated short segment the corporal body can be replaced using naturally derived collagen matrices with autologous cells. In current study, we examined feasibility engineering entire pendular bodies rabbit...
To assess critical heat spread of cautery instruments used in robot-assisted laparoscopic (RAL) surgery.Thermal along bovine musculofascial tissues was examined by infrared camera, histology and enzyme assay. Currently monopolar, bipolar ultrasonic were investigated at various power settings application times. The efficacy using an additional Maryland clamp as a sink evaluated. A temperature 45 °C considered the threshold for possible nerve damage.Monopolar exhibited mean (sem) thermal 3.5...
In tissue engineering, survival of larger constructs remains challenging due to limited supply oxygen caused by a lack early vascularization. Controlled release from small organic molecules represents possible strategy prevent cell death under anoxic conditions. A comprehensive study methylated pyridone-derived endoperoxides has led the development water-soluble that undergo retro-Diels-Alder reactions in aqueous environment releasing high yield and with half-lives up 13 h. These combination...