A5077099155- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Prostate Cancer Treatment and Research
- Urinary Bladder and Prostate Research
- Urological Disorders and Treatments
- Pelvic floor disorders treatments
- Radiomics and Machine Learning in Medical Imaging
- Urologic and reproductive health conditions
- Cancer Immunotherapy and Biomarkers
- Hormonal and reproductive studies
- Testicular diseases and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Renal cell carcinoma treatment
- Global Cancer Incidence and Screening
- Sexual Differentiation and Disorders
- MRI in cancer diagnosis
- Pediatric Urology and Nephrology Studies
- Urinary Tract Infections Management
- Cancer, Lipids, and Metabolism
- Lipoproteins and Cardiovascular Health
- Kidney Stones and Urolithiasis Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Pharmaceutical industry and healthcare
- Respiratory Support and Mechanisms
University Health Network
2019-2025
University of Toronto
2018-2025
Princess Margaret Cancer Centre
2019-2024
University Hospital of Zurich
2015-2024
University of Zurich
2015-2024
Luzerner Kantonsspital
2023
Prevention Institute
2023
Hirslanden Klinik Aarau
2023
University Hospital of Basel
2023
University Hospital of Bern
2023
While statins have demonstrated a variety of antineoplastic effects in preclinical studies, several retrospective clinical studies and observational not shown consistent chemopreventive benefit against prostate cancer (PCa). Therefore, this population-based cohort study, we examined the association statin intake on specific antigen (PSA) values risk development PCa.
To externally validate and compare the two novel versions of European Randomised Study for Screening Prostate Cancer (ERSPC)-prostate cancer risk calculator (RC) Prevention Trial (PCPT)-RC.All men who underwent a transrectal prostate biopsy in tertiary care centre between 2004 2012 were retrospectively identified. The probability detecting significant (Gleason score ≥7) was calculated each man using ERSPC-RC (DRE-based version 3/4) PCPT-RC (version 2.0) compared with results. Calibration...
We sought to determine which parsimonious combination of complete blood count (CBC)-based biomarkers most efficiently predicts oncologic outcomes in patients undergoing radical cystectomy (RC) for bladder cancer (BC).Using our institutional RC database (1992-2012), nine CBC-based markers (including both absolute cell counts and ratios) were evaluated based on pre-treatment measurements. The outcome measures recurrence-free survival (RFS), cancer-specific (CSS), overall (OS). Time-dependent...
We evaluated the diagnostic accuracy of multiparametric magnetic resonance imaging and imaging/transrectal ultrasound fusion guided targeted biopsy against that transperineal template saturation prostate to detect cancer.We retrospectively analyzed records 415 men who consecutively presented for between November 2014 September 2016 at our tertiary care center. Multiparametric was performed using a 3 Tesla device without an endorectal coil, followed by with BiopSee® system. Additional done in...
CD73 is a membrane associated 5'-ectonucleotidase that has been proposed as prognostic biomarker in various solid tumors. The aim of this study to evaluate expression cohort patients with primary bladder cancer regard its association clinicopathological features and disease course.Tissue samples from 174 urothelial carcinoma were immunohistochemically assessed on tissue microarray. Associations between retrospectively obtained data evaluated by contingency analysis. Survival analysis was...
BACKGROUND. The prognostic role of preoperative serum lipid levels in patients undergoing radical prostatectomy (RP) for clinically localized prostate cancer (PCa) is unclear. aim the present study was to investigate with PCa RP and their association clinicopathological features oncological outcome. METHODS. Preoperative (total cholesterol, LDL HDL cholesterol triglycerides) statin use from consecutive a tertiary referral center between 2008 2015 were recorded followed prospectively....
We sought to externally validate recently published prostate cancer risk calculators incorporating multiparametric magnetic resonance imaging predict clinically significant cancer. also compared the performance of these that naïve calculators.We identified men without a previous diagnosis who underwent transperineal template saturation biopsy with fusion guided targeted between November 2014 and March 2018 at our academic tertiary referral center. Any Gleason pattern 4 or greater was defined...
Objectives To determine whether air‐filled systems (AFS) provide comparable urodynamic investigation (UDI) trace quality to water‐filled (WFS), the recommended standard by International Continence Society. Patients and Methods A total of 490 patients undergoing UDI from April 2021 January 2022 were included in this non‐inferiority randomised controlled trial. Eligible female male adults with neurogenic lower urinary tract dysfunction (NLUTD). allocated block randomisation a 1:1 ratio undergo...
This study aims to characterize payments by drug and medical device manufacturers current program directors (PD) of the Society Urologic Oncology (SUO)-accredited fellowship programs in United States (US). PDs were identified from SUO websites as February 2024. Demographic data, educational background, scholarly metrics collected via an online search. Industry 2014 2023 extracted Open Payments database. Descriptive statistics used summarize PD characteristics industry payment details....
Objective To analyse whether the percentage of free to total prostate‐specific antigen (%fPSA) is a prognostic biomarker in metastatic castration‐resistant prostate cancer (mCRPC), as novel studies suggest an elevated %fPSA associated with adverse oncological outcomes for men biochemical recurrence cancer. Patients and Methods A biobank prospectively collated at mCRPC diagnosis was analysed %fPSA. Clinicopathological characteristics, systemic therapies survival were recorded. stratified by...
Objective To assess whether the distribution of concomitant carcinoma in situ (CIS; unifocal or multifocal) with papillary non‐muscle‐invasive bladder cancer (NMIBC) impacts risk progression, as CIS is an established factor for progression NMIBC and commonly used calculators do not make this distinction. Patients Methods In multi‐institutional retrospective cohort study from both academic community hospitals, clinicopathological data were collected patients pTa/pT1 treated 2005 to 2022....
Absorption of irrigation fluid was not detected during GreenLight™ laser vaporization the prostate using first generation 80 W laser. However, data are lacking on intraoperative absorption second 120 high power We assessed whether occurs prostate.We performed this prospective investigation at a tertiary referral center in patients undergoing for prostatic bladder outlet obstruction. Normal saline containing 1% ethanol used irrigation. The expired breath concentration measured periodically...