A5016448202- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Urinary and Genital Oncology Studies
- Prostate Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Cancer survivorship and care
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Urinary Tract Infections Management
- Urological Disorders and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Telemedicine and Telehealth Implementation
- Testicular diseases and treatments
- Palliative Care and End-of-Life Issues
- Surgical Simulation and Training
- Clinical practice guidelines implementation
- Organ Transplantation Techniques and Outcomes
- Brain Metastases and Treatment
- Multiple and Secondary Primary Cancers
- Health Systems, Economic Evaluations, Quality of Life
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Hormonal and reproductive studies
Trillium Health Centre
2017-2025
Credit Valley Hospital
2012-2025
University of Toronto
2017-2023
Memorial Sloan Kettering Cancer Center
2010-2023
Accreditation Council for Graduate Medical Education
2019
American Society of Clinical Oncology
2017-2018
University of North Carolina at Chapel Hill
2018
Durham VA Medical Center
2018
University of Pennsylvania
2018
University Health Network
2017
In April 2017, the American Urological Association, Society for Radiation Oncology, and of Urologic Oncology released a joint evidence-based practice guideline on clinically localized prostate cancer. The Clinical (ASCO) has policy set procedures endorsing clinical guidelines that have been developed by other professional organizations.The Clinically Localized Prostate Cancer was reviewed developmental rigor methodologists. An ASCO Expert Panel then content recommendations.The determined...
Abstract Purpose: We aimed to validate and improve prognostic signatures for high-risk urothelial carcinoma of the bladder. Experimental Design: evaluated microarray data from 93 patients with bladder cancer managed by radical cystectomy determine gene expression patterns associated clinical variables. compared our results published sets comprising 578 additional 49 multiple types. Hierarchical clustering was utilized identify subtypes differences in survival. then investigated whether...
Purpose To jointly update the Cancer Care Ontario guideline on brachytherapy for patients with prostate cancer to account new evidence. Methods An Update Panel conducted a targeted systematic literature review and identified more recent randomized controlled trials comparing dose-escalated external beam radiation therapy (EBRT) in men cancer. Results Five provided evidence this update. Recommendations For low-risk who require or choose active treatment, low–dose rate (LDR) alone, EBRT and/or...
22 Background: Metastases directed therapy (MDT) in metachronous hormone sensitive prostate cancer (mHSPS) patients has been shown to delay systemic and a lesser extent improve oncological outcome. To date there not strong data suggest benefit of MDT castration resistant (CRPC). In this multi-centric randomized phase II trial, we sought determine the stereotactic body radiotherapy (SBRT) oligometastatic CRPC (omCRPC) patients. Methods: PCS-9 was originally designed as an adaptive II/III...
Abstract BACKGROUND: Pelvic lymph node dissection (PLND) is an important component of prostate cancer staging and treatment, especially for surgical patients who have high‐risk tumor features. It not clear how the shift from open radical prostatectomy (ORP) to minimally invasive (MIRP) has affected use PLND. The objectives this study were identify predictors PLND assess impact technique in a contemporary, population‐based cohort. METHODS: In Surveillance, Epidemiology, End Results (SEER)...
Abstract BACKGROUND: Androgen deprivation therapy (ADT) improves prostate cancer outcomes in specific clinical settings, but is associated with adverse effects, including cardiac complications and possibly thromboembolic complications. The objective of this study was to estimate the impact ADT on events (TEs) a population‐based cohort. METHODS: In linked Surveillance, Epidemiology End Results–Medicare database, we identified men older than 65 who were diagnosed nonmetastatic between 1999...
Study Type – Therapy (practice patterns) Level of Evidence 2b What's known on the subject? and What does study add? The treatment locally advanced prostate cancer varies widely even though there is level one evidence supporting use multimodality therapy as compared with monotherapy. This defines patterns within United States identifies predicators who receives rather than OBJECTIVE To identify predictors receiving in patients (LAPC). PATIENTS AND METHODS cohort comprised ≥66 years clinical...
Robotic surgery to remove a cancerous prostate has become popular treatment. Internet marketing of this provides an intriguing case study direct-to-consumer promotions medical devices, which are more loosely regulated than pharmaceutical promotions. We investigated whether the claims made in online robotic prostatectomy were consistent with evidence from comparative effectiveness studies. After performing search and cross-sectional analysis websites that mentioned procedure, we found many...
The Canadian Cancer Society estimated 5900 new cases of renal cell carcinoma (RCC) and 1750 related deaths in Canada 2012. 1 RCC is the sixth eleventh most common cancer diagnosed men women, respectively, its incidence has been rising by about 2.3% per year, including period from 2005 to 2009. 2 Much this rise attributed incidental detection via abdominal imaging for other causes.Most these RCCs have small masses (SRMs), defined as solid-appearing less than 4 cm maximum diameter....
240 Background: Evidence supports multimodality treatment for muscle invasive bladder cancer [MIBC] with the strongest evidence (level 1) existing cisplatin-based neoadjuvant chemotherapy. Although reflected in guidelines management of MIBC, little is known about variation actual practice patterns among academic institutions. We thus evaluated 14 centers patients MIBC. Methods: Retrospective data were collected centralized analysis. All who underwent radical cystectomy clinical T2-4 N0M0...
Study Type – Therapy (outcomes research) Level of Evidence 2c OBJECTIVE To evaluate if two commonly used laparoscopic simulators could be adapted and successfully for the robotics platform in a roboticnaïve medical student population. MATERIALS AND METHODS We identified widely validated simulation programs, LapSim® (Surgical Science Sweden AB), ProMIS® (Haptica, Ireland)for inclusion study. The McGill Inanimate System Training Evaluation Laparoscopic Skills® task set was ProMIS, DaVinci®...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Jul 2002Analytical Accuracy and Reliability Commonly Used Nutritional Supplements in Prostate Disease Andrew H. Feifer, Neil E. Fleshner, Laurence Klotz FeiferAndrew Feifer , FleshnerNeil Fleshner KlotzLaurence View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)64850-1AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We...
Clinical pathways are designed to reduce variability in patient care practices and improve clinical outcomes. We evaluated the effect of implementing a pathway on length stay patients undergoing kidney surgery.After receiving institutional review board approval we prospective data consecutive cases partial radical nephrectomy performed at our institution from 2000 2011. identified 1,775 nephrectomies (1,449 open 326 minimally invasive) 1,025 (857 168 invasive). used multivariate linear...
Study Type – Prognosis (individual cohort) Level of Evidence 2b What's known on the subject? and What does study add? We know that patient fitness for surgery is a major predictor morbidity mortality after surgery. found published nomogram did not incorporate several clinical risk factors its predictive value was only slightly better than using patient's age Charlson score to predict perioperative morality. This limitation may be related lack availability these in national databases...
We aimed to develop an explainable machine learning (ML) model predict side-specific extraprostatic extension (ssEPE) identify patients who can safely undergo nerve-sparing radical prostatectomy using preoperative clinicopathological variables.A retrospective sample of data from 900 prostatic lobes at our institution was used as the training cohort. Primary outcome presence ssEPE. The baseline for comparison had highest performance out current biopsy-derived predictive models A separate...