A5037000183- Metabolomics and Mass Spectrometry Studies
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Algal biology and biofuel production
- Metabolism and Genetic Disorders
- Heavy Metal Exposure and Toxicity
- Identification and Quantification in Food
- Meat and Animal Product Quality
- Advanced Chemical Sensor Technologies
- Antibiotic Resistance in Bacteria
- Trace Elements in Health
- Neonatal Health and Biochemistry
- Protein Hydrolysis and Bioactive Peptides
- Bacterial Identification and Susceptibility Testing
- Photosynthetic Processes and Mechanisms
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Cancer, Hypoxia, and Metabolism
- Folate and B Vitamins Research
- Phytochemicals and Antioxidant Activities
- Head and Neck Cancer Studies
- GABA and Rice Research
- Insect and Pesticide Research
- Natural product bioactivities and synthesis
University of Karachi
2016-2025
International Center for Chemical and Biological Sciences
2016-2025
Institut Polytechnique de Bordeaux
2020
Université de Bordeaux
2020
Centre National de la Recherche Scientifique
2020
Abstract Chickpea is considered among the most important leguminous crops in world. However, recent years drought conditions and/or limited availability of water have significantly reduced production chickpea. The current study was aimed to understand legume stress response at metabolic level for determination chickpea genotypes which can resist yield losses and could be cultivated with availability. Here, we analyzed two chickpea, desi kabuli under rainfed condition using a GC–MS based...
Abstract Acute leukemia is a critical neoplasm of white blood cells. In order to differentiate between the metabolic alterations associated with two subtypes acute leukemia, lymphoblastic (ALL) and myeloid (AML), we investigated serum ALL AML patients compared controls (healthy aplastic anemia) using 1 H NMR (nuclear magnetic resonance) spectroscopy. Thirty-seven putative metabolites were identified Carr-Purcell-Meiboom-Gill (CPMG) sequence. The use PLS-DA OPLS-DA models gave results 84.38%...
Large scale usage of tobacco causes a lot health troubles in human. Various formulations are extensively used by the people particularly developing world. Besides several toxic constituents some metals and metalloids also believed to pose risks. This paper describes inductively coupled plasma-mass spectrometric (ICP-MS) quantification important various brands smoked, sniffed, dipped chewed products.A microwave-assisted digestion method was for sample preparation. The validated analyzing...
β-Thalassemia is one of the most prevalent forms congenital blood disorders characterized by reduced hemoglobin levels with severe complications, affecting all dimensions life. The mechanisms underlying phenotypic heterogeneity β-thalassemia are still poorly understood. We aimed to work over metabolite biomarkers improve mechanistic understanding and hence better management disorder at different levels. Untargeted serum metabolites were analyzed after protein precipitation SPE (solid phase...
Acute leukaemia (AL) is a critical neoplasm of white blood cells. Diagnosing AL requires bone marrow puncture procedure, which many patients do not consent to for it invasive. Hence sensitive and specific early diagnostic biomarkers are essential non-invasive diagnosis, new therapeutics improving the disease prognosis. To differentiate metabolic alterations associated with acute lymphoblastic (ALL) myeloid (AML), we investigated serum ALL AML in comparison two controls using gas...
Oral cancer is a major health challenge in the Indian subcontinent and dreadful form of cancers worldwide. The current study focused on identification distinguished metabolites oral tissue samples comparison with precancerous control using gas chromatography coupled triple quadrupole tandem mass spectrometry chemometric analyses. Metabolites obtained were identified through National Institute Standards Technology (NIST) spectral (Wiley registry) library. Mass Profiler Professional (MPP)...
Abstract Acute Leukaemia (AL) is a neoplasm of WBCs (white blood cells). Being an important class metabolites, alteration in free fatty acids (FFAs) levels play key role cancer development and progression. As they involve cell signaling, maintain membrane integrity, regulate homeostasis effect tissue functions. Considering this fact, comprehensive analysis FFAs was conducted to monitor their AL, pre-leukaemic diseases healthy control. Fifteen were analyzed 179 serum samples myelodysplastic...
Augmentation of fetal hemoglobin (HbF) production has been an enduring therapeutic objective in β-thalassemia patients for which hydroxyurea (HU) largely the drug choice and most cost-effective approach. A serum metabolomics study on 40 with prior to after administration HU was done along healthy controls. Treated were divided further into non-responders (NR), partial (PR) good (GR) per their response. 25 metabolites that altered before therapy at p ≤ 0.05 fold change >2.0 patients; started...
The experimental trial was conducted in saline water to determine the replacement level of fish meal with locally available plant protein source, soybean on growth performance, survival and body composition Nile Tilapia (Oreochromis niloticus) juveniles reared floating net cages.Four types diet (35% crude protein) were formulated where fishmeal replaced by meal, partially up 0%, 25%, 50% 75% designated as treatment T1, T2, T3 T4 respectively.The T1 control a main ingredient sole source...