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A5091835498
Research Areas
- Lipid metabolism and biosynthesis
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
Shenzhen University Health Science Center
2022
Abstract 17β-hydroxysteroid dehydrogenase-13 is a hepatocyte-specific, lipid droplet-associated protein. A common loss-of-function variant of HSD17B13 (rs72613567: TA) protects patients against non-alcoholic fatty liver disease with underlying mechanism incompletely understood. In the present study, we identify serine 33 17β-HSD13 as an evolutionally conserved PKA target site and its phosphorylation facilitates lipolysis by promoting interaction ATGL on droplets. Targeted mutation Ser33 to...
10.1038/s41467-022-34299-1
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Nature Communications
2022-11-02
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