A5010311212- Immune Cell Function and Interaction
- Electrocatalysts for Energy Conversion
- interferon and immune responses
- Bone Tumor Diagnosis and Treatments
- CAR-T cell therapy research
- Peroxisome Proliferator-Activated Receptors
- Fuel Cells and Related Materials
- Immunotherapy and Immune Responses
- Retinal Diseases and Treatments
- Cancer Cells and Metastasis
- Sarcoma Diagnosis and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer Immunotherapy and Biomarkers
- Electrochemical Analysis and Applications
- Immune cells in cancer
- Corneal Surgery and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Retinal Development and Disorders
- Tendon Structure and Treatment
- Hydrology and Watershed Management Studies
- Cytokine Signaling Pathways and Interactions
- Health Systems, Economic Evaluations, Quality of Life
- Virus-based gene therapy research
- Wnt/β-catenin signaling in development and cancer
- Glioma Diagnosis and Treatment
Ministry of Water Resources of the People's Republic of China
2019-2025
Wake Forest University
2022-2025
China Institute of Water Resources and Hydropower Research
2025
Lanzhou University
2014-2024
Lanzhou University Second Hospital
2016-2024
Xinjiang Production and Construction Corps
2024
Shihezi University
2024
University of Oklahoma Health Sciences Center
2020-2023
Northeastern University
2015-2021
Chinese PLA General Hospital
2009-2019
Abstract Replacement of noble metals in catalysts for cathodic oxygen reduction reaction with transition mostly create active sites based on a composite nitrogen-coordinated metal close concert non-nitrogen-coordinated carbon-embedded atom clusters. Here we report non-platinum group electrocatalyst an site devoid any direct nitrogen coordination to iron that outperforms the benchmark platinum-based catalyst alkaline media and is comparable its best contemporaries acidic media. In situ X-ray...
The biomimetic dynamic nature of the Fe–N–C active site with a near-optimal Fe<sup>2+/3+</sup>redox potential facilitates ORR by balancing site-blocking effect and O<sub>2</sub>dissociation.
Ni–Fe and Ni–Fe–Co mixed-metal oxide (MMO) films were investigated as electrocatalysts for the oxygen evolution reaction (OER) in 0.1 M KOH. In an effort to optimize MMO morphology, aniline was used a capping agent produce high-surface-area on Raney nickel supports. This catalyst exhibits enhanced mass activity comparison OER reported date. Cyclic voltammetry shows changes potential of Ni2+/3+ transitions Fe- or Co-containing films. situ X-ray absorption spectroscopy (XAS) analysis confirms...
Personal protective equipment (PPE) has been highly recommended by the U.S. Centers for Disease Control and Prevention self-protection during disastrous SARS-CoV-2 (COVID-19) pandemic. Nevertheless, massive utilization of PPE encounters significant challenges in recycling sterilizing used masks. To tackle associated plastic pollution masks, this work, we designed a reusable, biodegradable, antibacterial mask. The mask was fabricated electrospinning polyvinyl alcohol (PVA), poly(ethylene...
Despite recent progress in developing active and durable oxygen reduction catalysts with reduced Pt content, lack of elegant bottom-up synthesis procedures knowledge over the control atomic arrangement morphology Pt-alloy still hinders fuel cell commercialization. To follow a less empirical path for improved Pt-based catalysts, it is essential to correlate catalytic performance properties that can be easily controlled measured experimentally. Herein, using Pt-Co alloy nanoparticles (NPs)...
Macular edema caused by retinal vascular leakage and ocular neovascularization are the leading causes of severe vision loss in diabetic retinopathy (DR) age-related macular degeneration (AMD) patients. Oral administration fenofibrate, a PPARα agonist, has shown therapeutic effects on To improve drug delivery to retina its efficacy, we have developed nano-emulsion-based fenofibrate eye drop formulation that delivered significantly higher amounts compared systemic administration, as measured...
Diabetes can result in impaired corneal wound healing. Mitochondrial dysfunction plays an important role diabetic complications. However, the regulation of mitochondria function cornea and its impacts on healing remain elusive. The present study aimed to explore molecular basis for disturbed mitochondrial metabolism subsequent impairment cornea. Seahorse analysis showed that oxidative phosphorylation is a major source ATP production human epithelial cells. Live biopsy punches from type 1 2...
The Harnischia generic complex, a significant assemblage within the tribe Chi-ronomini, extensive global sampling and integration of multi-characteristic data for comprehensive analysis are essential to elucidate phylogenetic relationships complex. We sequenced, assembled, annotated mitochondrial genomes single species each from genera Parachironomus Lenz, Robackia Saether Saetheria Jackson. Additionally, we incorporated 26 previously published mitogenomes into our delve deeper...
To determine the mechanisms used to internalize mitochondria by corneal epithelial cells after in vivo trephine injury and vitro cells. Male female mice were subjected euthanized immediately, 6, 24 hours injury. Macropinocytosis was quantified using 70 kD fluorescent dextran. Mitochondrial content assessed immunofluorescence metabolic activity Seahorse assay immediately 6 In experiments human limbal (HCLE) isolated performed assess mitochondrial transfer presence of gap junction inhibitor...
Testosterone supplementation increases muscle mass in older men but has not been shown to consistently improve physical function and activity. It hypothesized that exercise is required induce the adaptations necessary for translation of testosterone-induced gain into functional improvements. However, effects testosterone plus low intensity training (T/PT) on performance bioenergetics are unknown. In this pilot study, we tested hypothesis combined administration T/PT would male mice late life...
Abstract Purpose: Elevated blood levels of C-reactive protein (CRP) are associated with both type 1 and 2 diabetes diabetic complications, such as retinopathy (DR). However, its pathogenic role in DR remains unknown. The present study aims to investigate the potential CRP pathogenesis explore underlying mechanism. Materials methods: Human transgenic (hCRP-Tg) rats were employed for streptozotocin (STZ)-induced oxygen-induced (OIR) models. retina function was monitored by electroretinography...
In ischemic retinopathy, overactivated retinal myeloid cells are a crucial driving force of pathological angiogenesis and inflammation. The cyclic GMP-AMP synthase (cGAS) stimulator interferon genes (STING) signaling key regulators This study aims to investigate the association cGAS-STING with retinopathy regulation its activation. We found that protein levels cGAS STING were markedly up-regulated in isolated from mice oxygen-induced (OIR). Knockout Sting pharmacological inhibition both...
It was reported previously that circulation levels of kallistatin, an endogenous Wnt signaling inhibitor, are increased in patients with diabetes. The current study conducted to determine the role kallistatin delayed wound healing diabetic corneas. Immunostaining and Western blot analysis showed were upregulated corneas from humans rodents In murine corneal models, canonical activated nondiabetic suppressed corneas, correlating healing. Transgenic expression activation cornea Local...
Anion immunity toward the oxygen reduction reaction (ORR) has tremendous implications in electrocatalysis with applications for fuel cells, metal–air batteries, and depolarized cathodes (ODCs) anodic evolution of chlorine. The necessity exploring ORR catalysts to anion adsorption is particularly significant considering that platinum group metal (PGM) are costly highly vulnerable impurities such as halides. Herein, we report a organic framework (MOF)-derived Fe–N–C catalyst exhibits...
Addition of immunoregulation factor to an oncolytic adenovirus being constructed is a developmental step in tumor gene therapy; however, cytokine IL-15 has not been frequently used as potential cancer therapy agent. Here, we E2F-1 promoter based on type 5 adenovirus, which induces viral replication and proliferation targeted cells. We inserted the into E3 region model found that human expressing (Ad-E2F/IL15) shows more intense antitumor effect than simple viruses (Ad-E2F) do. Precisely...
In vivo engineering of hepatic tissue based on primary hepatocytes offers new perspectives for the treatment liver diseases. However, generation thick, three-dimensional has been limited by lack vasculature in tissue-engineered constructs. Here, we used collagen hydrogel as a matrix to generate engineered units reconstitute three-dimensional, vascularized vivo. Hepatocytes harvested from Sprague-Dawley rats were mixed with liquid type I collagen, concentrated Dulbecco's modified Eagle's...
Monocyte activation plays an important role in diabetic complications such as retinopathy (DR). However, the regulation of monocyte diabetes remains elusive. Fenofibrate, agonist peroxisome proliferator-activated receptor-α (PPARα), has shown robust therapeutic effects on DR patients with type 2 diabetes. Here we found that PPARα levels were significantly downregulated monocytes from and animal models, correlating activation. Fenofibrate attenuated diabetes, while knockout alone induced...
Background. Diabetic keratopathy (DK) poses a significant challenge in diabetes mellitus, yet its molecular pathways and effective treatments remain elusive. The aim of our research was to explore the pyroptosis-related genes corneal epithelium streptozocin-induced diabetic rats. Methods. After sixteen weeks streptozocin intraperitoneal injection, from three rats normal groups underwent whole-transcriptome sequencing. An integrated bioinformatics pipeline, including differentially expressed...
Due to the anatomical structure of rectum, treatment rectal cancer remains challenging. Ad-E2F, an oncolytic adenovirus containing E2F-1 promoter, can selectively replicate within and kill cells derived from solid tumors. Thus, this virus provides a novel approach for cancer. Given poor efficacy possible adverse reactions that arise use alone results our analysis Ad-E2F in cancer, we investigated combination with adoptive immunotherapy using cytokine-induced killer (CIK) as therapeutic Our...
The role of peroxisome proliferator-activated receptor alpha (PPARα) in retinal biology is clarifying, and evidence demonstrates that novel PPARα agonists hold promising therapeutic utility for diseases like diabetic retinopathy age-related macular degeneration. Herein, we disclose the design initial structure–activity relationships a new biaryl aniline agonistic chemotype. Notably, this series exhibits subtype selectivity over other isoforms, phenomenon postulated to be due unique benzoic...