A5043852609- Retinal Diseases and Treatments
- Cancer-related molecular mechanisms research
- Glaucoma and retinal disorders
- Retinopathy of Prematurity Studies
- MicroRNA in disease regulation
- Retinal Imaging and Analysis
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Ocular Diseases and Behçet’s Syndrome
- interferon and immune responses
- Retinal and Macular Surgery
- Salivary Gland Tumors Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Connexins and lens biology
- Oral and Maxillofacial Pathology
- Retinal Development and Disorders
- Growth Hormone and Insulin-like Growth Factors
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Peptidase Inhibition and Analysis
- Genetics and Neurodevelopmental Disorders
- Ear and Head Tumors
- Cancer Mechanisms and Therapy
- Adipose Tissue and Metabolism
- Nuclear Receptors and Signaling
Tianjin Medical University
2016-2025
Tianjin Medical University Eye Hospital
2016-2025
Yantai Institute of Coastal Zone Research
2024
Chinese Academy of Sciences
2024
Zhejiang Ocean University
2024
National Clinical Research Center for Digestive Diseases
2023
Eye Center
2023
Taishan University
2023
Central South University
2021
Tianjin Chest Hospital
2021
The coastal wetlands of the Yellow River Delta (YRD) in China are crucial for their valuable resources, environmental significance, and economic contributions. However, these also vulnerable to dual threats climate change human disturbances. Despite substantial attention historical shifts YRD's wetlands, uncertainties remain regarding future trajectory face compounded risks from anthropogenic activities. Based on a range remote sensing data sources, this study undertakes comprehensive...
Aberrant expression of microRNAs (miRNAs) has been implicated in cancer initiation and progression. In this study, we found that microRNA-34a (miR-34a) is significantly downregulated glioblastoma multiforme (GBM) specimens compared with normal brain tissues. Growth curve colony formation assays revealed miR-34a suppresses proliferation U373MG SHG44 cells. Overexpression could induce apoptosis Also, identified notch1 as a direct target gene miR-34a. Knockdown showed similar cellular functions...
The purpose of this study was to explore the role microRNA-451a (miR-451a) in diabetic retinopathy through activating transcription factor 2 (ATF2). epiretinal membrane samples from patients with proliferative (PDR) were immunolabeled an antibody for Ki-67 identify cells. expression miR-451a measured by qRT-PCR retina Akita mice and RPE cells under conditions. potential downstream targets predicted bioinformatics confirmed dual luciferase assay, qRT-PCR, Western blotting. Mitochondrial...
Mesenchymal stem cells (MSCs) exhibit a potent immunomodulatory capacity and have been applied to treat diseases such as graft versus host disease severe autoimmune diseases. However, the mechanism underlying their immunosuppressive effect is not yet completely understood. Here, we investigated role of CD73/adenosine pathway in immune modulation by MSCs using mouse model experimental uveitis (EAU). Moreover, examined vitro modulatory mediated through human T cells. We found that severity EAU...
Abstract Background The epithelial–mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells participated in the development fibrosis. SB431542 is a small molecule inhibitor with inhibitory effects on ALK4, ALK5 and ALK7. Our study aimed to explore effect EMT RPE provide new ideas for treatment Methods We performed fundus fluorescein angiography, optical coherence tomography hematoxylin–eosin staining vivo observe choroidal neovascularization (CNV)-induced retinopathy....
Objective: Exploring the effect of transforming growth factor β receptor inhibitor SB431542 on autophagy and formation retinal epithelial mesenchymal transition (EMT) in pigment cells under high glucose conditions. Methods: This study was an experimental research. RPE were divided into normal group (N group), mannitol (M (HG combined with DMSO (HG+DMSO group) (HG+SB431542 group). MTT assay used to detect cell proliferation. Cell scratch migration. Phalloidin staining Fibrotic actin,...
Abstract The RandWPSO-VMD-MCKD method is introduced to address the challenge of detecting early failures in rolling bearings, which are often masked by noise and difficult discover. This approach combines Random Weight Particle Swarm Optimisation (RandWPSO) with Variational Mode Decomposition (VMD) Maximum Correlated Kurtosis Deconvolution (MCKD) improve reduction emphasise frequency faults. By using RandWPSO algorithm automatically optimise parameters both VMD MCKD, this aims effectively...
We tested the long-term effects of different regimens mesenchymal stem cell (MSC) administration in a recurrent experimental autoimmune uveitis (rEAU) model rats, and compared efficacy MSC to that dexamethasone (DEX).
Fresh camel milk was widely accepted to help prevent and control of diabetes, especially in Africa, Middle East, cooler dry areas Asia. In this study, type 2 diabetic patients were enrolled supplement with 10 g powder twice a day for 4 weeks (n = 14), cow served as the placebo 13). It found that decreased fasting blood glucose, 2-hr postprandial serum content total cholesterol, resistin, lipocalin-2. There also significant increase osteocrin, amylin, GLP-1in group, indicating an improvement...
Monocyte activation plays an important role in diabetic complications such as retinopathy (DR). However, the regulation of monocyte diabetes remains elusive. Fenofibrate, agonist peroxisome proliferator-activated receptor-α (PPARα), has shown robust therapeutic effects on DR patients with type 2 diabetes. Here we found that PPARα levels were significantly downregulated monocytes from and animal models, correlating activation. Fenofibrate attenuated diabetes, while knockout alone induced...
Hepatocyte growth factor (HGF) induced the proliferation of lens epithelial cells (LECs) and may be a major cause posterior capsule opacification (PCO), which is most frequent postoperative complication cataract surgery. To date, several agents that can block LECs have been studied, but none used in clinic. Recently, accumulating evidence has suggested rapamycin, inhibitor mTOR (mammalian target Rapamycin), was associated with induction apoptosis LECs. The purpose our study to investigate...
We have previously reported that MSCs inhibited experimental autoimmune uveitis (EAU) in rodent models induced by either uveitogenic antigens or antigen-specific T cells. In this study, we explored the inhibitory mechanisms of on dendritic cells (DCs) EAU.We collected DCs from lymph nodes MSC treated untreated EAU rats, as well bone marrow derived cultured vitro with without treatment. The levels costimulatory molecules CD80, CD86, CD40, OX40L and suppressors cytokine signaling (SOCS1,...
Regulation of transcription requires cooperation between sequence-specific factors and numerous coregulatory proteins. In IL-4/IL-13 signaling several coactivators for STAT6 have been identified, but the molecular mechanisms STAT6-mediated gene are still not fully understood. Here we identified by proteomic approach that PTB-associated splicing factor (PSF) interacts with STAT6. intact cells interaction was observed only after IL-4 stimulation. The IL-4-induced tyrosine phosphorylation both...
Primary open-angle glaucoma (POAG) is characterized by irreversible neurodegeneration accompanied visual field defects and high intraocular pressure. Currently, an effective treatment not available to prevent the progression of POAG, other than treatments decrease We performed proteomic analysis aqueous humour (AH) samples from patients with POAG combined cataract obtain a better understanding pathogenesis explore potential targets for this condition. Samples were collected 10 cataract. each...
Abnormal neovascularization is the most common cause of blindness, and hypoxia alters tissue metabolism, function, morphology. HIF-1α, transcriptional activator VEGF, has intricate mechanisms nuclear translocation activation, but its signal termination remain unclear.
Background: Numerous metabolic parameters can be changed during hemodialysis in the end-stage renal disease (ESRD) caused by systemic diseases, such as diabetes mellitus, hypertension. Some ocular also variable due to changes after hemodialysis. This study evaluates effects of parameters, including best-corrected visual acuity (BCVA), intraocular pressure (IOP), central macular thickness (CMT), subfoveal choroidal (SFCT), retinal arteriolar caliber (RAC), venular calibre (RVC), ESRD patients...
To determine the difference of surgical induced astigmatism between conventional 20-gauge sutured vitrectomy and 23-gauge transconjunctival sutureless vitrectomy, influence corneal pachymetry intraocular pressure (IOP) on in diabetic patients.This retrospective, consecutive case series consisted 40 eyes 38 subjects who underwent either or vitrectomy. The curvature thickness were measured with Scheimpflug imaging before surgery 1wk; 1, 3mo after surgery. We compared (SIA) true net power group...
Abstract Background Data on the association of subclinical hypothyroidism (SCH) with severity coronary artery disease and major adverse cardiovascular cerebral events (MACCE) in patients non‐ST‐segment elevation acute syndrome (NSTE‐ACS) after percutaneous intervention (PCI) are limited conflicting. Objective We established baseline rate SCH followed trajectory thyroid‐stimulating hormone (TSH) values during hospitalisation for PCI up to six months determined whether persistent was...