A5076471787- Gastrointestinal motility and disorders
- Cancer Treatment and Pharmacology
- Congenital gastrointestinal and neural anomalies
- Mesenchymal stem cell research
- Cancer, Stress, Anesthesia, and Immune Response
- Oral health in cancer treatment
- Neuropeptides and Animal Physiology
- Helicobacter pylori-related gastroenterology studies
- Cancer-related cognitive impairment studies
- Cancer Immunotherapy and Biomarkers
- Ion Channels and Receptors
- Gut microbiota and health
- Infant Health and Development
- Diet and metabolism studies
- Cancer Cells and Metastasis
- Tryptophan and brain disorders
- Inflammatory Bowel Disease
- Cancer, Lipids, and Metabolism
- Immune Cell Function and Interaction
- Eosinophilic Esophagitis
- Colorectal Cancer Treatments and Studies
- Chemotherapy-induced organ toxicity mitigation
- Nausea and vomiting management
- Digestive system and related health
- Axon Guidance and Neuronal Signaling
Victoria School of Management
2014-2024
Victoria University
2015-2024
Australian Institute for Musculoskeletal Science
2017-2024
Western Health
2015-2024
The University of Melbourne
2008-2024
Australian Institute of Music
2020-2024
Sunshine Hospital
2015-2023
University of Newcastle Australia
2000
Despite considerable progress in patient care, the global incidence of various cancer types continues to rise. Developing safer and more efficient anti-cancer treatment approaches are great interest. In recent decades, nanotechnology has emerged as a promising innovative medical approach for diagnosis treatment. However, nanomedicine advances, it is important understand address challenges. Herein, we identify gaps current understanding effectiveness on clinical outcomes provide an outlook...
Expression of PD-1 on T/B cells regulates peripheral tolerance and autoimmunity. Binding to its ligand, PD-L1, leads protection against self-reactivity. In contrary, tumor have evolved immune escape mechanisms whereby overexpression PD-L1 induces anergy and/or apoptosis positive T by interfering with cell receptor signal transduction. blockade using antibodies are in human clinical trials as an alternative cancer treatment modality. Areas covered: We describe the role PD-1/PD-L1 disease...
1. Intracellular recordings made in single bundle strips of a visceral smooth muscle revealed rhythmic spontaneous membrane depolarizations termed slow waves (SWs). These exhibited 'pacemaker' and 'regenerative' components composed summations more elementary events transient (STDs). 2. STDs SWs persisted the presence tetrodotoxin, nifedipine ryanodine, upon brief exposure to Ca2+-free Cd2+-containing solutions; they were enhanced by ACh blocked BAPTA AM, cyclopiazonic acid caffeine. 3. also...
Abstract We report on the first correlative study of electrophysiological properties, shapes, and projections enteric neurons in mouse. Neurons myenteric plexus mouse colon were impaled with microelectrodes containing biocytin, their passive active properties determined, responses to activation synaptic inputs investigated. Biocytin, injected into from which recordings made, was converted an optically dense product used determine shapes neurons. By almost all belonged one two classes, AH or...
Background and Purpose Oxaliplatin is a platinum‐based chemotherapeutic drug used as first‐line therapy for colorectal cancer. However, its use associated with severe gastrointestinal side‐effects resulting in dose limitations and/or cessation of treatment. In this study, we tested whether oxidative stress, caused by chronic oxaliplatin treatment, induces enteric neuronal damage colonic dysmotility. Experimental Approach (3 mg·kg −1 per day) was administered vivo to Balb/c mice...
The use of the anticancer chemotherapeutic agent 5-fluorouracil (5-FU) is often limited by nausea, vomiting, constipation, and diarrhea; these side-effects persist long after treatment. effects 5-FU on enteric neurons have not been studied may provide insight into mechanisms underlying 5-FU-induced gastrointestinal dysfunction.Balb/c mice received intraperitoneal injections (23 mg/kg) 3 times/week for 14 days. Gastrointestinal transit was analysed in vivo prior to following 3, 7, days...
The progression of breast cancer and its association with clinical outcome treatment remain largely unexplored. Accumulating data has highlighted the interaction between cells immune system tumor microenvironment in progression, although studies have identified multiple facets within development (TME) constituents, there is lack research into associations subtype staging. Current literature provided insight pathways associated through expression analysis. However, co-expression TME that form...
Chemotherapy-induced diarrhoea (CID) is a common side-effect experienced by patients being treated with variety of antineoplastic agents. Approximately 80% undergoing chemotherapeutic treatment for colorectal and other gastrointestinal cancers present CID; moreover, about 5% early deaths associated combination anti-cancer chemotherapy are due to CID. Chronic post-treatment amongst cancer survivors can persist more than 10 years greatly effecting long-term quality life. Gastrointestinal...