A5028719889- Psoriasis: Treatment and Pathogenesis
- Autoimmune Bullous Skin Diseases
- Reproductive System and Pregnancy
- Acne and Rosacea Treatments and Effects
- Pregnancy and Medication Impact
- Genomics and Phylogenetic Studies
- Antifungal resistance and susceptibility
- Cancer-related molecular mechanisms research
- Pharmaceutical studies and practices
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Pregnancy and preeclampsia studies
- melanin and skin pigmentation
- Dermatology and Skin Diseases
- Health Systems, Economic Evaluations, Quality of Life
- RNA and protein synthesis mechanisms
- Skin Protection and Aging
Xi'an Medical University
2025
Xiangya Hospital Central South University
2024
Central South University
2024
Southern Medical University
2024
UCB Pharma (United States)
2017-2021
Rosacea is a chronic inflammatory skin disorder, whose underlying cellular and molecular mechanisms remain obscure. Here, we generate single-cell atlas of facial from female rosacea patients healthy individuals. Among keratinocytes, subpopulation characterized by IFNγ-mediated barrier function damage found to be unique lesions. Blocking IFNγ signaling alleviates rosacea-like phenotypes in mice. The papulopustular featured expansion pro-inflammatory fibroblasts, Schwann, endothelial...
To assess the effectiveness of aerobic exercise combined with systematic nursing care on psychological well-being and pregnancy outcomes patients gestational hypertension. A study was conducted 200 hypertension treated from May 2023 to 2024. Patients were assigned an observation group (n=110), which received care, or a control (n=90), standard care. Both groups monitored until delivery. Pre- post-intervention comparisons included scores for negative emotions, blood pressure, outcomes,...
Abstract Subcellular localization of RNA is a crucial mechanism for regulating diverse biological processes within cells. Dynamic subcellular localizations are essential maintaining cellular homeostasis; however, their distribution and changes during development differentiation remain largely unexplored. To elucidate the dynamic patterns cells, we have upgraded RNALocate to version 3.0, repository RNA-subcellular (http://www.rnalocate.org/ or http://www.rna-society.org/rnalocate/). v3.0...
<h3>Background</h3> Women with active chronic rheumatic inflammatory conditions (RA, PsA, AxSpA) often face uncertainty regarding the safety of use biologics during breastfeeding.<sup>1</sup> Limited and non-validated data exist on potential transfer anti-TNFs into breast milk.<sup>2</sup> CRADLE (NCT02154425) was first sponsored study to evaluate certolizumab pegol (CZP) concentrations in milk, estimate Average Daily Infant Dose (ADID) maternal CZP. <h3>Objectives</h3> To determine...
<h3>Background</h3> There is a need for effective and safe treatment during pregnancy in women affected by chronic active inflammatory diseases, such as rheumatoid arthritis. Adequate disease control crucial to ensure the best fetal maternal health, reduce adverse outcomes.<sup>1,2</sup> Anti-TNFs are an therapeutic option, but because most cross placenta, they often stopped pregnancy.<sup>3,4</sup> Certolizumab pegol (CZP), due its Fc-free molecular structure, has no placental transfer...
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