A5114626411- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Acne and Rosacea Treatments and Effects
- Immune Response and Inflammation
- melanin and skin pigmentation
- Infectious Encephalopathies and Encephalitis
- Immune Cell Function and Interaction
- Nosocomial Infections in ICU
- Bone Metabolism and Diseases
- Chemical Synthesis and Reactions
- Pharmacological Effects of Natural Compounds
- interferon and immune responses
- S100 Proteins and Annexins
- Potato Plant Research
- Mitochondrial Function and Pathology
- Atherosclerosis and Cardiovascular Diseases
- Antimicrobial Peptides and Activities
- Synthetic Organic Chemistry Methods
- Cardiovascular Function and Risk Factors
- Hair Growth and Disorders
- Respiratory Support and Mechanisms
- Dermatology and Skin Diseases
- Pregnancy and preeclampsia studies
- Bone health and treatments
- Cardiac Imaging and Diagnostics
National Center of Biomedical Analysis
2024-2025
Xinjiang Medical University
2022-2025
Second Affiliated Hospital of Xinjiang Medical University
2022-2025
Inner Mongolia Medical University
2015-2024
Chifeng Municipal Hospital
2021-2024
Xiangya Hospital Central South University
2023-2024
Central South University
2022-2024
Air Force Medical University
2023-2024
Dalian Medical University
2009-2022
Chongqing Medical University
2009-2022
The recognition of cytosolic nucleic acids is a critical step in the host immune response against danger signals, such as molecular patterns from pathogens or tissue damage. Nonetheless, over-reactivity to self-nucleic leads sustained production type I interferon (IFN), mediated either by cGAS RLR, contributing pathogenesis certain autoimmune diseases, Aicardi–Goutières syndrome (AGS). Therefore, inhibiting excessive IFN represents potential therapeutic strategy for conditions. In this...
Accurate identification of delirium in sepsis patients is crucial for guiding clinical diagnosis and treatment. However, there are no accurate biomarkers indicators at present. We aimed to identify which combinations cognitive impairment-related other easily accessible assessments best predict patients.
Hospital mortality is high for patients with encephalopathy caused by microbial infection. Microbial infections often induce sepsis. The damage to the central nervous system (CNS) defined as sepsis-associated (SAE). However, relationship between pathogenic microorganisms and prognosis of SAE still unclear, especially gut microbiota, there no clinical tool predict hospital patients. study aimed explore develop a nomogram prediction in patients.The retrospective cohort study. lasso regression...
Objective: The study aims to develop a mechanical learning model as predictive for predicting the appearance of sepsis-associated encephalopathy (SAE). Materials and Methods: prediction was developed in primary cohort 2,028 sepsis patients from June 2001 October 2012, retrieved Medical Information Mart Intensive Care (MIMIC III) database. Least absolute shrinkage selection operator (LASSO) regression used data dimension reduction feature selection. using multivariable logistic analysis....
Background: Aging is characterized by the gradual loss of physiological integrity, resulting in impaired function and easier death. This deterioration a major risk factor for human pathological diseases, including cancer, diabetes, cardiovascular disease neurodegenerative diseases. It very important to find biomarkers that can prevent aging. Methods: Q-Exactive-MS was used proteomic detection young senescence fibroblast. The key senescence-related molecules (SRMs) were identified integrating...
Rosacea is a common inflammatory skin disorder mediated by the dysregulation of both keratinocytes and T cells.Here, we report that aquaporin 3 (AQP3), channel protein mediates transport water/glycerol, was highly expressed in epidermis CD4 + cells rosacea patients experimental mice.Specifically, AQP3 deletion blocked development rosacea-like inflammation model mice with LL37-induced disease.We also present mechanistic evidence showing essential to activation NF-κB signaling subsequent...
The purpose of this study was to examine the changes cellular cholesterol efflux from macrophages in patients with type II diabetes mellitus (DM), and determine expression CYP7A1, ABCG5, LXRβ therein.We recruited 30 DM (including 15 complicated coronary heart disease only) normal controls for study.Peripheral blood monocytes were isolated macrophage culture.The mRNA protein levels determined using real-time polymerase chain reaction western blot.The rate 10% autoserum standard serum as...
Dendritic cells (DCs) are crucial in initiating and shaping both innate adaptive immune responses. Clinical studies experimental models have highlighted their significant involvement various autoimmune diseases, positioning them as promising therapeutic targets. Nicotinamide (NAM), a form of vitamin B3, with its anti-inflammatory properties, has been suggested, while the NAM DCs regulation remains elusive. Here, through analyzing publicly available databases, we observe substantial...
: Sepsis-associated encephalopathy (SAE) is a common complication in the acute phase of sepsis, and patients who develop SAE have higher mortality rate, longer hospital stay, worse quality life than other sepsis patients. Although incidence as high 70% patients, no effective treatment available for this condition. To an SAE, it vital to explore its pathogenesis. It known that hyperammonemia possible factor pathogenesis hepatic ammonia potent neurotoxin. Furthermore, our previous studies...
Objectives Acute respiratory failure increases short-term mortality in sepsis patients. Hence, this study, we aimed to develop a novel model for predicting the risk of hospital patients with acute failure.Methods From Medical Information Mart Intensive Care (MIMIC)-IV database, developed matched cohort adult failure. After applying multivariate COX regression analysis, nomogram based on identified factors mortality. Further, evaluated ability individual death by area under receiver operating...
Relapsed childhood polymicrobial osteomyelitis associated with dermatophytosis has not been reported in the literature.Here we report on a case of 45-year-old man who had left tibial for 29 years, accompanied by skin fungal infection ipsilateral heel 20 and underwent second operation due to recurrence 6 years ago. The patient history injury from rusty object, which penetrated anterior tibia middle segment causing subsequent bone infection, but was asymptomatic after receiving treatments...
This study analyzed the different levels of aortic remodeling in patients with DeBakey IIIb dissection (AD) after thoracic endovascular repair (TEVAR) at a single center.In all, 66 AD who underwent TEVAR acute (Group A) or subacute phase SA) from January 2012 to October 2016 were included study. The change lumen (A), true (TL), false (FL), and index (TLi) analyzed.There was no statistically significant difference clinical information morphologic imaging findings Groups A SA. At proximal...
This study aimed to identify preoperative and postoperative risk factors of venous thromboembolism (VTE) after gastrectomy in gastric cancer (GC) patients.757 GC patients underwent at our institution 246 with elevated D-dimer levels who received Doppler ultrasonography lower/upper extremity veins were enrolled. Clinicopathological data collected, the differences clinicopathological between VTE (+) (-) groups analyzed. Univariate multivariate logistic regression analyses performed independent...
In order to study the recognition methods of underwater targets in harsh environments and improve accuracy image based target recognition, a deep learning method was carried out. Propose simulation for environment images on clearer samples. The processing mainly includes adding random scale spatial position obstructions, noise, obtaining simulated data. Establish an integrated dataset, which original data results models trained dataset have significantly improved compared dataset.
This paper introduced and studied the passenger oxygen supply methods of civil aircraft, analyzed demonstrated that pulse air method does not meet airworthiness requirement, proposed to bring forward equivalent verification requirement based on blood saturation, a feasible test theoretical analysis saturation. First, it minimum supplemental flow rate required by CCAR25 regulation. Second, saturation level with same effect as value tracheal partial pressure 133.3hPa 111.7hPa is 92% 85%,...
Abstract From easily available camphoric acid, endo‐2‐hydroxyepicamphor 1 and endo‐3‐hydroxycamphor 2 have been prepared as a mixture which can be further separated to pure forms. This method offers convenient synthesis of 2.