A5019037217- Veterinary Oncology Research
- Gut microbiota and health
- Microbial infections and disease research
- Mycobacterium research and diagnosis
- Intestinal and Peritoneal Adhesions
- Simulation-Based Education in Healthcare
- Polyomavirus and related diseases
- Mesenchymal stem cell research
- Antimicrobial Resistance in Staphylococcus
- Helicobacter pylori-related gastroenterology studies
- Veterinary Practice and Education Studies
- Milk Quality and Mastitis in Dairy Cows
- Infectious Diseases and Mycology
- Veterinary Orthopedics and Neurology
- Animal Behavior and Welfare Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Cardiac tumors and thrombi
- IL-33, ST2, and ILC Pathways
- Clostridium difficile and Clostridium perfringens research
- Sarcoma Diagnosis and Treatment
- Child and Adolescent Psychosocial and Emotional Development
- Innovations in Medical Education
- Veterinary Medicine and Surgery
- Respiratory viral infections research
- Pancreatic and Hepatic Oncology Research
Colorado State University
2021-2024
University of Connecticut
2023
Cornell University
2012-2020
New York State College of Veterinary Medicine
2020
Texas A&M University
2019
University of Wisconsin–Madison
2017-2018
Abstract Background Tylosin is commonly prescribed to dogs with diarrhea. Orally administered antibiotics may alter the intestinal microbiota, which responsible for crucial key bile acid (BA) biotransformation reactions. Objectives To prospectively evaluate impact of tylosin administration on fecal microbiota and unconjugated acids (UBAs) over time. Animals Sixteen healthy adult dogs. Methods Prospective, randomized controlled clinical trial. Dogs were receive 20 mg/kg or a placebo capsule...
French Bulldogs develop a form of granulomatous colitis (GC) with histopathological resemblance to GC Boxer dogs (GCB). GCB is associated mucosally invasive Escherichia coli whose eradication correlates clinical remission.To characterize the and features, presence or absence colonic bacteria, response fluoroquinolones in GC.A total 6 histological diagnosis GC.Retrospective study medical records. Bacterial colonization was evaluated using 16S rRNA probes for eubacteria E. coli. Biopsy...
Abstract Background Diet may induce clinical remission in dogs with chronic enteropathy (CE). Elemental diets (EDs), providing protein as amino acids, modulate intestinal immunity and microbiome rodents humans. Hypothesis Evaluate the impact of an acid‐based kibble (EL) on CE activity gastrointestinal (GI)‐relevant variables. Animals Client‐owned (n = 23) inadequately controlled CE. Methods Prospective, uncontrolled trial. Diagnostic evaluation including upper lower GI endoscopy was...
Chronic inflammatory enteropathy (CIE) is a common condition in dogs causing recurrent or persistent gastrointestinal clinical signs. Pathogenesis thought to involve intestinal mucosal infiltrates, but histopathological evaluation of biopsies from with CIE fails guide treatment, inform prognosis, correlate remission. We employed single-cell RNA sequencing catalog and compare the diversity cells present duodenal endoscopic 3 healthy 4 CIE. Through characterization 35,668 cells, we identified...
To describe acute respiratory distress syndrome (ARDS) and septic shock in a cat with disseminated toxoplasmosis.A 2-year-old neutered male domestic shorthair was presented for distress. At the time of presentation it had been receiving cyclosporine treatment eosinophilic dermatitis. Thoracic radiographs revealed severe mixed nodular interstitial alveolar patterns. An endotracheal wash performed, which confirmed diagnosis pulmonary toxoplasmosis. Despite initial oxygen supplementation...
Eradication of intramucosal Escherichia coli correlates with remission periodic acid-Schiff-positive E coli-associated granulomatous colitis (GC). Treatment failures attributed to multidrug resistant (MDR) bacteria necessitate alternative approaches.Determine clinical outcome GC in dogs treated based on antimicrobial susceptibility profiling and characterize phylogeny resistance mechanisms.Twenty Boxers 4 French Bulldogs GC.Culture, profiling, molecular characterization were performed...
Bile acids (BA) are important metabolites secreted into the intestinal lumen and impacted by luminal microbes dietary intake. Prior studies in humans rodents have shown that BAs immunologically active primary secondary distinct immune properties. Therefore, composition of gut BA pool may influence GI inflammatory responses. The current study investigated relative modulatory properties (cholic acid, CA) (lithocholic LCA) assessing their effects on canine macrophage cytokine secretion receptor...
Extraskeletal osteosarcoma (EOSA) in dogs is a rare malignant mesenchymal tumor of somatic soft tissues or more commonly visceral organs with poor prognosis. In dogs, EOSAs have been described as arising from multiple locations, but differently humans, never main vessel. this report, we describe the first case an EOSA post-hepatic caudal vena cava 7-year-old male neutered mix breed dog. This report focuses on description diagnostic challenges to obtain preoperative diagnosis, highlights...
To evaluate the veterinary student learning outcome of 2 methods equine rectal examination training.Randomized prospective study.Veterinary students (3rd and 4th year; n = 40) practicing veterinarians (n 10).Year 1: Group 1 11) 10) received skilled instructor (SI) laparoscopic-guidance (LG), respectively, during exam instruction. All were tested on identification 4 abdominal organs. Year 2: One group 19) was trained subsequently using each technique, first SI, followed by LG. Subjective...
Treatment of Mycoplasma spp. pneumonia has rarely been described in domestic ferrets (Mustela putorius furo). A 10-month-old, 0.53 kg, female spayed ferret was presented for oxygen-dependent, chronic dyspnea one-month's duration. Physical examination findings included dyspnea, tachypnea, increased bronchovesicular sounds bilaterally, and an intermittent non-productive cough. Bloodwork abnormalities a mild leukocytosis (8.6 x 103/µL), neutrophilia (4.0 hypoalbuminemia (2.7 g/dL),...
The antineoplastic agent cyclophosphamide (CP) has dose-limiting side effects including sterile haemorrhagic cystitis (SHC), bone marrow (BM) suppression and gastrointestinal (GI) toxicity in dogs. metabolites acrolein phosphoramide that mediate these toxicities are glutathione-S-transferase (GST) substrates, low functioning GST alleles associated with CP humans. aim of this study was to determine whether variants 2 canine genes, GSTT1 GSTT5, were over-represented dogs developed toxicity....
Chronic rhinitis (CR) is a frustrating clinical syndrome in dogs and our understanding of the disease pathogenesis limited. Increasingly, host–microbe interactions are considered key drives sites persistent mucosal inflammation such as nasal oral cavities. Therefore, we applied next generation sequencing tools to interrogate abnormalities present nose with CR compared immune microbiome profiles those healthy dogs. Host cell transcriptomes were evaluated by RNA sequencing, while microbial...