A5004824117- Gut microbiota and health
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Microbial Metabolites in Food Biotechnology
- Gastrointestinal motility and disorders
- Escherichia coli research studies
- Celiac Disease Research and Management
- Clinical Nutrition and Gastroenterology
- Infant Nutrition and Health
- Systemic Sclerosis and Related Diseases
University of Alberta
2018-2024
<h3>Background & aims</h3> Inflammatory bowel diseases (IBD) are affected by dietary factors, including nondigestible carbohydrates (fibers), which fermented colonic microbes. Fibers overall beneficial, but not all fibers alike, and some patients with IBD report intolerance to fiber consumption. Given reproducible evidence of reduced fiber-fermenting microbes in IBD, we hypothesized that remain intact select can then bind host cell receptors, subsequently promoting gut inflammation....
Exclusive enteral nutrition (EEN) is effective in inducing remission pediatric Crohn disease (CD). EEN alters the intestinal microbiome, but precise mechanisms are unknown. We hypothesized that pre-diagnosis diet establishes a baseline gut which then mediates response to EEN. analyzed prospectively recorded food frequency questionnaires (FFQs) for dietary patterns. Fecal microbiota were sequenced (16SrRNA) at and through an 18-month follow-up period. Dietary patterns, Mediterranean...
Inflammatory bowel diseases (IBD), including Crohn disease (CD) and ulcerative colitis (UC), affect 1 in 150 Canadians, 25% of new cases are diagnosed children. IBD manifests with chronic gastrointestinal inflammation an altered intestinal microbiome. Dietary changes impact IBD, as shown by the effective pediatric CD therapy exclusive enteral nutrition (EEN), which entails intake liquid meal-replacement for 6–8 weeks. EEN adherence can be challenging costly to families; biomarkers more...
Abstract Background The etiology of inflammatory bowel diseases (IBD) remains unknown, although gut microorganisms and diet have been implicated. Dietary fibers pass through the undigested are fermented within intestine by microbes, promoting health. However, many IBD patients describe experiencing sensitivity to fibres. Interestingly, fiber receptors on immune cells able interact with typically found surface fungal (which share properties dietary fibers), for example, resulting in a...
Abstract Background The pathogenesis of pCD remains poorly understood, but evidence suggests roles for genetics, environment, immune response, and gut microbes. Microbial changes can contribute to chronic inflammation correlate with disease severity. Metabolomics reflects interactions between host microbial function by quantifying compounds in biological samples. Therefore, metabolomics provides a unique opportunity gain insight into pathogenesis. Aims To severity, metabolites, clinical data...
Abstract Background Dietary fibers pass through the bowel undigested and are fermented within intestine by microbes, typically promoting gut health. However, many IBD patients describe experiencing sensitivity to fibers. β-glucan, found on surface of fungal cells during infection, has been shown bind fiber receptors, such as Dectin-1, host immune cells, resulting in a pro-inflammatory response. These fibres share properties with dietary Aims As an altered microbial composition associated...