A5048129610- Bariatric Surgery and Outcomes
- Nutrition and Health in Aging
- Obesity and Health Practices
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Cardiovascular Disease and Adiposity
- Body Contouring and Surgery
- Diabetes Treatment and Management
- Diabetes Management and Education
- Iron Metabolism and Disorders
- Diet, Metabolism, and Disease
- Esophageal and GI Pathology
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gastroesophageal reflux and treatments
- Lipid metabolism and disorders
- Biochemical Analysis and Sensing Techniques
- Pancreatitis Pathology and Treatment
- Chronic Kidney Disease and Diabetes
- Frailty in Older Adults
- Childhood Cancer Survivors' Quality of Life
- Birth, Development, and Health
Geisinger Health System
2016-2025
Geisinger Medical Center
2009-2024
Epsom and St Helier University Hospitals NHS Trust
2022
Danville Community College
2002-2022
Geisinger Neuroscience Institute
2011-2016
NYU Langone Health
2013
Albert Einstein College of Medicine
2013
Macquarie University
2011
Valley Hospital
2006
Englewood Hospital and Medical Center
2006
Elucidation of the genetic factors underlying chronic liver disease may reveal new therapeutic targets.
To understand variation in prevalence of urinary incontinence (UI) and risk factors, given different definitions.The National Health Nutrition Examination Survey 2001-2002 data on UI were used. Prevalence, severity, associated factors stress, urge, mixed, any estimated 2,875 adult women. Severe was defined as a few times or more per week. Moderate an frequency month only, mild year only. Odds ratios for the association potential examined logistic regression model.The overall 23.7%, 9.9%,...
OBJECTIVE Roux-en-Y gastric bypass (RYGB) in humans can remit type 2 diabetes, but the operative mechanism is not completely understood. In mice, fibroblast growth factor (FGF) 15 (FGF19 humans) regulates hepatic bile acid (BA) production and also resolve diabetes. this study, we tested hypothesis that FGF19–BA pathway plays a role remission of human diabetes after RYGB surgery. RESEARCH DESIGN AND METHODS Cohorts diabetic nondiabetic individuals various body weights were used. addition,...
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) promote weight loss by suppressing appetite, enhancing satiety, regulating glucose metabolism, and delaying gastric motility. We sought to determine whether GLP-1 RA use could affect medical procedures such as EGD.
Gastric bypass surgery is an effective therapy for extreme obesity. However, substantial variability in weight loss outcomes exists that remains largely unexplained. Our objective was to determine whether any commonly collected preoperative clinical variables were associated with following Roux-en-Y gastric (RYGB) surgery. The analysis based on a prospectively recruited observational cohort of 2,365 patients who underwent from 2004 2009. Weight stratified into three major phases, early (0-6...
Obesity and its association with reduced life expectancy are well established, cardiovascular disease as one of the major causes fatality. Metabolic surgery is a powerful intervention for severe obesity, resulting in improvement comorbid diseases risk factors. This study investigates relationship between metabolic long-term events.A cohort Roux-en-Y gastric bypass (RYGB) patients was tightly matched by age, body mass index, sex, Framingham Risk Score, smoking history, use antihypertension...
Abstract Objective: We modified existing standardized measurement tools in the Physical Performance Test and tasks from Frailty Injuries: Cooperative Studies of Intervention Technique Study to evaluate physical function older women. Our objectives were (1) characterize themes based on combinations (deriving factors or components) (2) quantify correlation between derived body mass index (BMI). Research Methods Procedures: Nutrition risk screens enrollees a Medicare‐managed program served as...
Genome-wide association and linkage studies have identified multiple susceptibility loci for obesity. We hypothesized that such may affect weight loss outcomes following dietary or surgical interventions. A total of 1,001 white individuals with extreme obesity (BMI >35 kg/m(2)) who underwent a preoperative diet/behavioral intervention Roux-en-Y gastric bypass surgery were genotyped single-nucleotide polymorphisms (SNPs) in near the fat mass obesity-associated (FTO), insulin induced gene 2...
Abstract Background The effectiveness of weight loss therapies is commonly measured using body mass index and other obesity-related variables. Although these data are often stored in electronic health records (EHRs) potentially very accessible, few studies on obesity have used derived from EHRs. We developed processes for obtaining the EHR order to construct a database patients undergoing Roux-en-Y gastric bypass (RYGB) surgery. Methods Clinical obtained as part standard care bariatric...
The transmembrane 6 superfamily member 2 ( TM6SF2 ) loss‐of‐function variant rs58542926 is a genetic risk factor for nonalcoholic fatty liver disease and progression to fibrosis but paradoxically associated with lower levels of hepatically derived triglyceride‐rich lipoproteins. expressed predominantly in small intestine, sites lipoprotein biogenesis export. In light this, we hypothesized that may exhibit analogous effects on both intestine lipid homeostasis. To test genotyped 983 bariatric...
OBJECTIVE This study assessed all-cause and specific-cause mortality after Roux-en-Y gastric bypass (RYGB) in matched control subjects, stratified by diabetes status. RESEARCH DESIGN AND METHODS RYGB patients were age, BMI, sex, status at time of surgery to nonsurgical subjects using data from the electronic health record. Kaplan-Meier curves Cox regression used assess differences between with without diabetes. RESULTS Of 3,242 eligible enrolled January 2004 December 2015, identified for...
Objective The epidemiology of post‐gastric bypass surgery hypoglycemia (PGBH) is incompletely understood. This study aimed to evaluate the risk PGBH among nondiabetic patients and associated factors. Methods A cohort who underwent Roux‐en‐Y gastric (RYGB) was conducted. defined by any postoperative record glucose < 60 mg/dL, diagnosis hypoglycemia, or medication use for treatment PGBH. Kaplan‐Meier analysis used describe occurrence, log‐rank tests, Cox regression examine Results Of 1,206...
Nonalcoholic fatty liver disease (NAFLD) is a prevalent complication of extreme obesity. Loading the with fat can progress to inflammation and fibrosis including cirrhosis. The molecular factors involved in progression from simple steatosis remain poorly understood. Gene expression profiling using microarray, PCR array, RNA sequencing was performed on biopsy tissue patients Patients were grouped based histological findings normal histology no steatosis, lobular inflammation, or fibrosis,...
No AccessJournal of UrologyAdult Urology1 Nov 2009A Prospective Study Risk Factors for Nephrolithiasis After Roux-en-Y Gastric Bypass Surgeryis accompanied byGastric Procedures and Renal Calculi—How Should We Counsel Patients Bariatric Surgeons?Effect Potassium Citrate Therapy on the Stone Formation During Spaceflight Alyssa M. Park, Douglas W. Storm, Brant R. Fulmer, Christopher D. Still, G. Craig Wood, James E. Hartle ParkAlyssa Park , StormDouglas Storm FulmerBrant Fulmer StillChristopher...
Abstract Non-alcoholic fatty liver disease (NAFLD) represents a spectrum of conditions that include steatohepatitis and fibrosis are thought to emanate from hepatic steatosis. Few robust biomarkers or diagnostic tests have been developed for steatosis in the setting obesity. We multi-component classifier comprised phenotypic, genomic, proteomic variables using data 576 adults with extreme obesity who underwent bariatric surgery intra-operative biopsy. Using 443 patient training set, protein...
Weight loss after bariatric surgery varies, yet preoperative clinical factors associated with long-term suboptimal outcomes are not well understood.To evaluate the association between and weight Roux-en-Y gastric bypass (RYGB).From June 2001 to September 2007, this retrospective cohort study followed up RYGB patients before 7 12 years surgery. The setting was a large rural integrated health system. Of 1033 eligible who consented participate in longitudinal research completed October total of...
Objective Obstructive sleep apnea (OSA) is common among candidates for bariatric surgery. OSA and its associated intermittent hypoxia have been implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) steatohepatitis. A large cohort surgery patients was studied an effort to explore relationship between severity, hypoxia, metabolic syndrome, severity NAFLD. Methods Bariatric who underwent both polysomnography biopsy were studied. The as determined by apnea‐hypopnea index...