A5007324190- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- Cardiac Ischemia and Reperfusion
- Ion channel regulation and function
- Bariatric Surgery and Outcomes
- Colorectal Cancer Screening and Detection
- Cardiac Arrest and Resuscitation
- Bacterial Identification and Susceptibility Testing
- Regulation of Appetite and Obesity
- Fuel Cells and Related Materials
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- Urinary Tract Infections Management
- Kruppel-like factors research
- Receptor Mechanisms and Signaling
- Respiratory viral infections research
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic Syndromes and Imprinting
- Diabetes Treatment and Management
- Sepsis Diagnosis and Treatment
- Biochemical Analysis and Sensing Techniques
- Heart Failure Treatment and Management
- Neuroscience and Neuropharmacology Research
Geisinger Medical Center
2010-2024
Geisinger Health System
2014-2021
OBJECTIVE Roux-en-Y gastric bypass (RYGB) in humans can remit type 2 diabetes, but the operative mechanism is not completely understood. In mice, fibroblast growth factor (FGF) 15 (FGF19 humans) regulates hepatic bile acid (BA) production and also resolve diabetes. this study, we tested hypothesis that FGF19–BA pathway plays a role remission of human diabetes after RYGB surgery. RESEARCH DESIGN AND METHODS Cohorts diabetic nondiabetic individuals various body weights were used. addition,...
Background The melanocortin 4 receptor (MC4R) critically regulates feeding and satiety. Rare variants in MC4R are predominantly found obese individuals. Though some rare discovered patients have defects localization, ligand binding signaling to cAMP, many no recognized defects. Subjects/Methods In our cohort of 1433 subjects that underwent Roux-en-Y Gastric Bypass (RYGB) surgery, we fifteen MC4R. We matched variant carriers with the reference alleles for gender, age, starting BMI T2D...
Fibroblast growth factors 19 and 21 (FGF19 FGF21) have been implicated, independently, in type 2 diabetes (T2D) but it is not known if their circulating levels correlate with each other or whether the associated hepatic signaling mechanisms that play a role glucose metabolism are dysregulated diabetes. We used cross-sectional, case/control, experimental design involving Class III obese patients undergoing Roux-en-Y bariatric surgery (RYGB), measured FGF19 FGF21 serum gene expression (mRNA)...
K<sub>ATP</sub> channels are metabolic sensors and targets of potassium channel openers (KCO; e.g., diazoxide pinacidil). They comprise four sulfonylurea receptors (SUR) subunits (Kir6) critical in regulating insulin secretion. Different SUR subtypes (SUR1, SUR2A, SUR2B) largely determine the sensitivities pharmacological profiles channels. SUR1- but not SUR2-containing highly sensitive to inhibition diazoxide, whereas SUR2 pinacidil. It is generally believed that SUR1 incompatible...
G protein-activated inwardly rectifying potassium (GIRK or Kir3) channels are directly gated by the βγ subunits of proteins and contribute to inhibitory neurotransmitter signaling pathways. Paradoxically, volatile anesthetics such as halothane inhibit these channels. We find that neuronal Kir3 currents highly sensitive inhibition halothane. Given result from increased Gβγ available channels, we asked whether reducing channel would adversely affect inhibition. Remarkably, scavenging using...
The enterohepatic pathway involving the fibroblast growth factor 19 (FGF19) and bile acids (BA) has been linked with etiology remission of type 2 diabetes (T2D) following Roux-en-Y gastric bypass (RYGB) surgery. Specifically, diabetic patients had lower FGF19 circulating levels but postoperative BA were higher in that experience T2D, as compared to non-diabetic do not remission. It proposed this may be due direct flow digestate-free into ileum benefiting mostly T2D without severe diabetes.We...
Abstract Background Acute febrile illnesses (AFIs) represent a significant disease burden globally; however, the lack of reliable, rapid point-of-care testing makes diagnosis difficult. A simple tool for distinguishing bacterial versus non-bacterial infections would radically improve patient management and reduce indiscriminate antibiotic use. MeMed BV® (MMBV) is blood test to reliably differentiate between viral infections. Three host proteins (TRAIL, IP-10, CRP) are measured quantitatively...