A5059554821- Stroke Rehabilitation and Recovery
- Transcranial Magnetic Stimulation Studies
- Botulinum Toxin and Related Neurological Disorders
- Motor Control and Adaptation
- Muscle activation and electromyography studies
- EEG and Brain-Computer Interfaces
- Cerebral Palsy and Movement Disorders
- Neural and Behavioral Psychology Studies
- Acute Ischemic Stroke Management
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Action Observation and Synchronization
- Memory and Neural Mechanisms
- Neuroscience and Music Perception
- Peripheral Nerve Disorders
- Autoimmune Neurological Disorders and Treatments
- Neuroscience and Neural Engineering
- Whipple's Disease and Interleukins
- Polyomavirus and related diseases
- Dementia and Cognitive Impairment Research
- Facial Nerve Paralysis Treatment and Research
- Hemispheric Asymmetry in Neuroscience
- Parkinson's Disease Mechanisms and Treatments
- Vestibular and auditory disorders
University of Maryland, Baltimore
2014-2024
University of Maryland Rehabilitation & Orthopaedic Institute
2024
VA Maryland Health Care System
2014-2022
Baltimore VA Medical Center
2019-2022
Emory University
2021
University of Southern California
2020
The University of Melbourne
2020
Fujifilm (Japan)
2020
University of Maryland, College Park
2017
Foundation for Physical Medicine and Rehabilitation
2016
Imagining motor acts is a cognitive task that engages parts of the executive system. While imagery has been intensively studied using neuroimaging techniques, most studies lack behavioral observations. Here, we used functional MRI to compare neuroanatomy execution and objectively assesses performance. With surface electromyographic monitoring within scanner, 10 healthy subjects performed sequential finger-tapping movements according visually presented number stimuli in either movement or an...
Stroke is a leading cause of long-term motor disability among adults. Present rehabilitative interventions are largely unsuccessful in improving the most severe cases impairment, particularly relation to hand function. Here we tested hypothesis that patients experiencing plegia as result single, unilateral subcortical, cortical or mixed stroke occurring at least 1 year previously, could be trained operate mechanical orthosis through brain-computer interface (BCI).
Activation of motor-related areas has consistently been found during various motor imagery tasks and is regarded as the central mechanism generating imagery. However, extent to which execution share neural substrates remains controversial. We examined brain activity preparation for physical or mental finger tapping. During a functional magnetic resonance imaging at 3 T, 13 healthy volunteers performed an instructed delay finger-tapping task either in mode mode. Number stimuli subjects about...
Recent work demonstrated that application of peripheral nerve and cortical stimulation independently can induce modest improvements in motor performance patients with stroke. The purpose this study was to test the hypothesis combining (PNS) paretic hand anodal direct current (tDCS) ipsilesional primary cortex (M1) would facilitate beneficial effects training more than each intervention alone or sham (tDCS(Sham) PNS(Sham)).Nine chronic stroke completed a blinded crossover designed study. In...
Learning induces neuronal receptive field (RF) plasticity in primary auditory cortex. This constitutes physiological memory as it is associative, highly specific, discriminative, develops rapidly, and retained indefinitely. study examined whether pairing a tone with activation of the nucleus basalis could induce RF waking guinea pig and, if so, be for 24 hr. Subjects received 40 trials single frequency paired electrical stimulation (NB) at offset. The effectiveness NB was assessed later...
Learning alters receptive field (RF) tuning in the primary auditory cortex (ACx) to emphasize frequency of a tonal conditioned stimulus. RF plasticity is candidate substrate memory, as it associative, specific, discriminative, rapidly induced, and enduring. The authors hypothesized that produced by release acetylcholine ACx from basal forebrain (BasF), caused presentation reinforced but not nonreinforced stimuli. Waking adult male Hartley guinea pigs (n = 16) received 1 2 tones followed BasF...
The excitability of the human primary motor cortex (M1) as tested with transcranial magnetic stimulation (TMS) depends on its previous history neural activity. Homeostatic plasticity might be one important physiological mechanism for regulation corticospinal and synaptic plasticity. Although homeostatic has been demonstrated locally within M1, it is not known whether priming M1 could result in similar effects homologous opposite hemisphere. Here, we sought to determine down-regulating...
Recent anatomical evidence from nonhuman primates indicates that cingulate motor areas (CMAs) play a substantial role in the cortical control of upper facial movement. Using event-related functional magnetic resonance imaging 10 healthy subjects, we examined brain activity associated with volitional eye closure involving primarily bilateral orbicularis oculi. The findings were compared those bimanual tapping, which should identify medial frontal nonsomatotopically or somatotopically related...
Background Repetitive task practice reduces mean upper extremity motor impairment in populations of patients with chronic stroke, but individual response is highly variable. A method to predict meaningful reduction training based on biomarkers and other data collected prior an intervention needed establish realistic rehabilitation goals effectively allocate resources. Objectives To identify prognostic factors better understand the biological substrate for reductions arm repetitive among (≥6...
Abstract Objective To evaluate the safety of onabotulinumtoxinA treatment for spasticity across dose ranges in real-world practice. Design Adult Spasticity International Registry (ASPIRE) was a multicenter, prospective, observational study (NCT01930786) adult over 2 years. Adverse events (AEs), serious AEs (SAEs), treatment-related (TRAEs), and TRSAEs were sorted into 5 categories (≤200 U, 201-400 401-600 601-800 ≥801 U) based on cumulative per session. Results In 3103 sessions (T), 730...
Up to two-thirds of stroke survivors experience persistent sensorimotor impairments. Recovery relies on the integrity spared brain areas compensate for damaged tissue. Deep grey matter structures play a critical role in control and regulation circuits. The goal this work is identify associations between volumes subcortical nuclei behaviour at different timepoints after stroke. We pooled high-resolution T1-weighted MRI scans behavioural data 828 individuals with unilateral from 28 cohorts...
Abstract Paraneoplastic symptoms caused by abnormal gastrointestinal motility may be the initial manifestation of small cell lung cancer (SCLC). We report a case 63‐year‐old woman who presented with progressive constipation culminating in obstipation, and associated more widespread dysmotility. A paraneoplastic syndrome was suspected. The only abnormality on chest computed tomography minimally enlarged paratracheal lymph node. Positron emission demonstrated increased activity antinuclear...
To develop a clinically useful patient-reported screening tool for health care providers to identify patients with spasticity in need of treatment regardless etiology.Eleven experts participated modified Delphi panel and reviewed revised 2 iterations designed symptoms impact on daily function sleep. Spasticity expert panelists evaluated items pooled from existing questionnaires gain consensus the content. The study also included cognitive interviews 20 varying etiologies determine if draft...
Learning alters receptive field (RF) tuning in the primary auditory cortex (ACx) to emphasize frequency of a tonal conditioned stimulus. RF plasticity is candidate substrate memory, as it associative, specific, discriminative, rapidly induced, and enduring. The authors hypothesized that produced by release acetylcholine ACx from basal forebrain (BasF), caused presentation reinforced but not nonreinforced stimuli. Waking adult male Hartley guinea pigs (n = 16) received 1 2 tones followed BasF...
To demonstrate the feasibility of algorithmic prediction using a model baseline arm movement, genetic factors, demographic characteristics, and multimodal assessment structure function motor pathways. identify prognostic factors biological substrate for reductions in impairment response to repetitive task practice.This prospective single-group interventional study seeks predict practice program an intent-to-treat paradigm. Response is measured as change ≥5 points on Upper Extremity...
The goal of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Stroke Recovery working group is to understand brain and behavior relationships using well-powered meta- mega-analytic approaches. ENIGMA has data from over 1,800 stroke patients collected across 32 research sites 10 countries around world, comprising largest multi-site retrospective collaboration date. This paper outlines efforts taken by develop neuroinformatics protocols methods manage magnetic resonance...