5-HMF is widely presented in foods and produced through the degradation of hexoses Maillard reaction during heat treatment containing reducing sugars amino acids an acid environment. However, controversial conclusions on biological effects have been drawn previous studies. Therefore, main aim this study was to investigate antioxidant antiproliferative activities 5-HMF. The 2,2'-azinobis-3-ethylbenzothiazolin-6-sulfonic (ABTS) assay, 1,1-diphenyl-2-picryhydrazyl (DPPH) hemolysis assay induced...

Chronic wound healing is often impaired by bacterial infection and weak trans-epithelial potential. Patches with electrical stimulation bactericidal activity may solve this problem. However, inconvenient power resistant antibiotics limit their application. Here, we proposed a self-powered intrinsic patch based on triboelectric nanogenerator (TENG). Electrospun polymer tribo-layers chemical vapor-deposited polypyrrole electrode are assembled as the TENG, offering excellent flexibility,...

Abstract Infected burn wounds are characterized by persistent drug‐resistant bacterial infection coupled with an inflammatory response, impeding the wound‐healing process. In this study, intelligent nanoparticle system (CCM+TTD@ZIF‐8 NPs) was prepared using curcumin (CCM), aggregation‐induced emission luminogens (TTD), and ZIF‐8 for infection‐induced wound healing. The CCM+TTD@ZIF‐8 NPs showed multiple functions, including bacteria targeting, fluorescence imaging pH response‐guided...

Magnetoelectric stimulation is a promising therapy for various disorders due to its high efficacy and safety. To explore potential in chronic skin wound treatment, we developed magnetoelectric dressing, CFO@CTAB/PVDF (CCP), by electrospinning cetyltrimethylammonium bromide-modified CoFe2O4 (CFO) particles with polyvinylidene fluoride. Cetyltrimethylammonium bromide (CTAB) serves as dispersion surfactant CFO, quaternary ammonium cations imparting antibacterial hydrophilic properties the...

Bladder cancer has become the most common malignant urinary carcinoma. Studies have shown that significant antioxidant and bladder cancer-fighting properties of several plant-based diets like Psidium guajava, ginger amomum, are associated with their high kaempferol content. In this paper, we evaluated anticancer activities its mechanism induction to apoptosis on cells. Our findings demonstrated showed an obvious radical scavenging activity in erythrocytes damaged by oxygen. Kaempferol...

Bacterial infection and insufficient neovascularization are two major obstacles to the healing of chronic wounds. Here, we present an antibacterial proangiogenic dressing by encapsulating dimethyloxalylglycine (DMOG) in zeolitic imidazolate framework-8 (ZIF-8) electrospinning it with gelatin-polycaprolactone (Gel-PCL). As Gel-PCL nanofibers degrade, ZIF-8 nanoparticles decompose, sequentially releasing bactericidal zinc ions angiogenic DMOG molecules. This cascade process matches...

Selenocystine (SeC) has been identified as a novel compound with broad-spectrum anticancer activities. Natural borneol (NB) is monoterpenoid that used promoter of drug absorption. In the present study, we demonstrated NB significantly enhanced cellular uptake SeC and potentiated its antiproliferative activity on HepG2 cells by induction apoptosis. effectively synergized to reduce cancer cell growth through triggering apoptotic death. Further mechanistic studies Western blotting showed...

The aims of this study were to prepare a thermosensitive composite hydrogel (TCH) by mixing 24% (w/v) poloxamer 407 (P407), 16% 188 (P188) and 0.1% carbopol 940 (C940), determine the effect natural borneol/ (2-hydroxypropyl)-β-cyclodextrin (NB/HP-β-CD) inclusion complex on phase transition temperature, mechanical, rheological properties, release behaviors TCH using tube inversion method, texture analyzer, rheometer, in vitro , respectively. results showed that as concentration NB/HP-β-CD...

The use of selenium for anticancer therapy has been heavily explored during the last decade. Amino acids (AAs) play central roles both as building blocks proteins and intermediates in metabolism. In present study, AAs-modified nanoparticles (SeNPs@AAs) have successfully synthesized a simple redox system. Typical neutral (valine), acidic (aspartic acid) basic (lysine) amino were used to decorate SeNPs, stable homodisperse characterized by zeta potential transmission electron microscope....

Background Bovine serum albumin (BSA) contains high affinity binding sites for several endogenous and exogenous compounds has been used to replace human (HSA), as these two share a similar structure. Naringin palmitate is modified product of naringin that produced by an acylation reaction with palmitic acid, which considered be effective substance enhancing lipophilicity. In this study, the interaction BSA was characterised spectroscopic molecular docking techniques. Methodology/Principal...

Abstract Borneol, a natural extract with unique bicyclic monoterpene structure, has attracted increasing attention due to its broad‐spectrum antibacterial properties via membrane disruption mechanism. However, the negligible water solubility of borneol limits efficiency. Herein, borneol‐based water‐soluble agents are designed and synthesized combat multi‐drug resistant bacteria. The integration hydrophilic poly( N , ‐dimethylethyl methacrylate) (PDMAEMA) polymer chains boosts capability...

Abstract Food packaging materials, especially biodegradable polymer composites incorporated with natural antimicrobial agents excellent antibacterial activities, are in high demand and attracted immense attention. Herein, a polycaprolactone/curcumin@zeolitic imidazolate framework‐8 (PCL/Cur@ZIF‐8) composite film enhanced activity was developed. Curcumin, photosensitizer, loaded the highly porous nanocrystals ZIF‐8 to improve its poor water solubility stability. The integral structure of...

Antimicrobial photodynamic therapy (aPDT) is a highly attractive due to its advantages of being non-antibiotic procedure for reducing drug-resistant microbes. Curcumin (CCM) has been considered as natural photosensitizer PDT with prominent antibacterial, antifungal, and anti-proliferative activity. However, excellent biological pharmacological activities are limited because low solubility, rapid metabolization instability. Herein, we reported promising agent based on CCM-incorporated into...

Bismuth telluride (Bi2Te3) is an available thermoelectric material with the lowest band gap among bismuth chalcogenides, revealing a broad application in photocatalysis. Unfortunately, its size and morphology related to radio-catalysis property have rarely been explored. Herein, ethylenediaminetetraacetic acid (EDTA)-assisted hydrothermal strategy was introduced synthesize polytypic Bi2Te3 nanoplates (BT NPs) that exhibit size-dependent radio-sensitization metabolism characteristics vivo. By...

Both heavy metals and antibiotics exert selection pressure on bacterial resistance, as they are commonly co-contaminated in the environment, may play a larger role resistance. This study examined how breeding cycles affect antibiotic resistance genes (ARGs) chicken manure surrounding topsoils at 20, 50, 100, 200, 300 m from twelve typical laying hen farms Ningxia Hui Autonomous Region of northwest China. Six antibiotics, seven metals, ten mobile genetic elements (MGEs), microbial community...

Transportation-induced damage to fresh produce is a big challenge in logistics. Current acceleration and pressure sensors for collision monitoring face issues of power dependency, high cost, environmental concerns. Here, self-powered environmentally friendly triboelectric sensor has been developed monitor fruit collisions transportation packaging. Microcrystalline cellulose/chitosan sodium alginate films were prepared as positive negative tribo-layers assemble natural polysaccharide...

A multiple PCR for the detection of integrase genes three classes integrons was carried out, and their gene cassettes were characterized in 111 clinical strains Escherichia coli isolated Guangzhou City, China during last 6 years. IntI1 intI2 detected 95 isolates (85.6%) four (3.6%), respectively. No intI3 detected. Six different found these strains, a high prevalence dfr aad observed. The E. that contained 1664-bp amplicon dfrA17-aadA5 class 1 integron to be phylogenetically unrelated each...

Abstract Background Pure 1, 3-diacylglycerols (1, 3-DAG) have been considered to be significant surfactants in food, cosmetics and pharmaceutical industries, as well the effect on obesity prevention. Methods In this study, a vacuum-driven air bubbling operation mode was developed evaluated for enzymatic synthesis of 3-DAG saturated fatty acids, by direct esterification glycerol with acids solvent-free system. The employed comparable N 2 protocol, terms lauric acid conversion 3-dilaurin...

This study was to investigate the synergistic effect of NB/Cur on growth and apoptosis in A375 human melanoma cell line by MTT assay, flow cytometry Western blotting. Our results demonstrated that NB effectively synergized with Cur enhance its antiproliferative activity cells induction apoptosis, as evidenced an increase sub-G1 population, DNA fragmentation, PARP cleavage caspase activation. Further mechanistic studies blotting showed after treatment NB/Cur, up-regulation expression level...

Lactobacillus brevis is a major hop-resistance bacterium which poses significant challenge for the brewing industry, mainly due to difficulty or incapability in detection by routine culturing methodology and its beer spoilage ability.This study aimed at investigating VBNC state of strain, L. BM-LB13908. The culturable, total viable numbers cells were calculated MRS agar plate counting, acridine orange direct count (AODC) method Live/Dead BacLight bacterial viability kit with fluorescence...

Our findings provide comprehensive evidence that isoquercitrin (ISO) influenced T24 bladder cancer cell metabolism by activating the AMPK pathway as identified combination with metabolomics and immunoblotting assay.

Noninvasive photothermal therapy (PTT) is an emerging strategy for eliminating multidrug-resistant (MDR) bacteria that achieve sterilization by generating temperatures above 50 °C; however, such a high temperature also causes collateral damage to healthy tissues. In this study, we developed low-temperature PTT based on borneol-containing polymer-modified MXene nanosheets (BPM) with bacteria-targeting capabilities. BPM was fabricated through the electrostatic coassembly of negatively charged...