Fabliha A. Anam
A5023302154- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
- Respiratory viral infections research
- Intensive Care Unit Cognitive Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Inflammasome and immune disorders
- Intramuscular injections and effects
- Diabetes and associated disorders
- SARS-CoV-2 detection and testing
- Dermatology and Skin Diseases
- Cancer Immunotherapy and Biomarkers
- Immune responses and vaccinations
- Immunotherapy and Immune Responses
- Kawasaki Disease and Coronary Complications
Emory University
2020-2024
A wide spectrum of clinical manifestations has become a hallmark the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 pandemic, although immunological underpinnings diverse disease outcomes remain to be defined. We performed detailed characterization B cell responses through high-dimensional flow cytometry reveal substantial heterogeneity in both effector and immature populations. More notably, critically ill patients displayed hallmarks extrafollicular activation shared...
Abstract Severe SARS-CoV-2 infection 1 has been associated with highly inflammatory immune activation since the earliest days of COVID-19 pandemic 2–5 . More recently, these responses have emergence self-reactive antibodies pathologic potential 6–10 , although their origins and resolution remained unclear 11 Previously, we others identified extrafollicular B cell activation, a pathway formation new autoreactive in chronic autoimmunity 12,13 as dominant feature severe critical (refs. 14–18 )....
While immunologic correlates of COVID-19 have been widely reported, their associations with post-acute sequelae (PASC) remain less clear. Due to the wide array PASC presentations, understanding if specific disease features associate discrete immune processes and therapeutic opportunities is important. Here we profile patients in recovery phase via proteomics screening machine learning find signatures ongoing antiviral B cell development, immune-mediated fibrosis, markers death but not...
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple autoantibody types, some of which are produced long-lived plasma cells (LLPC). Active SLE generates increased circulating antibody-secreting (ASC). Here, we examine the phenotypic, molecular, structural, and functional features ASC in SLE. Relative to post-vaccination healthy controls, blood from patients with active enriched newly generated mature CD19 − CD138 + ASC, similar bone marrow LLPC....
Abstract An emerging feature of COVID-19 is the identification autoreactivity in patients with severe disease that may contribute to pathology, however origin and resolution these responses remain unclear. Previously, we identified strong extrafollicular B cell activation as a shared immune response between both advanced rheumatic disease. In autoimmune settings, this pathway associated relaxed peripheral tolerance antibody secreting compartment generation de novo autoreactive responses....
Abstract/Introduction A wide clinical spectrum has become a hallmark of the SARS-CoV-2 (COVID-19) pandemic, although its immunologic underpinnings remain to be defined. We have performed deep characterization B cell responses through high-dimensional flow cytometry reveal substantial heterogeneity in both effector and immature populations. More notably, critically ill patients displayed hallmarks extrafollicular activation as previously described autoimmune settings. Extrafollicular...
Abstract SARS-CoV-2 has caused over 100,000,000 cases and almost 2,500,000 deaths globally. Comprehensive assessment of the multifaceted antiviral Ab response is critical for diagnosis, differentiation severity, characterization long-term immunity, especially as COVID-19 vaccines become available. Severe disease associated with early, massive plasmablast responses. We developed a multiplex immunoassay from serum/plasma acutely infected convalescent patients prepandemic postpandemic healthy...
ABSTRACT Post-acute sequelae of SARS-CoV-2 (SARS2) infection (PASC) is a heterogeneous condition, but the main viral drivers are unknown. Here, we use MENSA, Media Enriched with Newly Synthesized Antibodies, secreted exclusively from circulating human plasmablasts, to provide an immune snapshot that defines underlying triggers. We proof-of-concept testing MENSA technology can capture new host response accurately diagnose acute primary and breakthrough infections when known SARS2 virus or...
Severe acute respiratory syndrome coronavirus 2 mRNA vaccination has reduced effectiveness in certain immunocompromised individuals. However, the cellular mechanisms underlying these defects, as well contribution of disease-induced abnormalities, remain largely unexplored. In this study, we conducted a comprehensive serological and analysis patients with autoimmune systemic lupus erythematosus (SLE) who received Wuhan-Hu-1 monovalent disease 2019 vaccine. Our findings revealed that SLE...
Abstract Novel mRNA vaccines have resulted in a reduced number of SARS-CoV-2 infections and hospitalizations. Yet, there is paucity studies regarding their effectiveness on immunocompromised autoimmune subjects. In this study, we enrolled subjects naïve to from two cohorts healthy donors (HD, n=56) systemic lupus erythematosus (SLE, n=69). Serological assessments circulating antibodies revealed significant reduction potency breadth neutralization the SLE group, only partially rescued by 3 rd...
Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by multiple autoantibodies, some of which are present in high titers a sustained, B cell-independent fashion consistent with their generation from long-lived plasma cells (LLPC). Active SLE displays numbers circulating antibody-secreting (ASC). Understanding the mechanisms and survival ASC would contribute important insight into pathogenesis novel targeted therapies. We studied properties through systematic analysis...
SARS-CoV-2 has caused over 36,000,000 cases and 1,000,000 deaths globally. Comprehensive assessment of the multifaceted anti-viral antibody response is critical for diagnosis, differentiation severe disease, characterization long-term immunity. Initial observations suggest that disease associated with higher levels greater B cell/plasmablast responses. A multi-antigen immunoassay to define complex serological landscape clinical associations essential. We developed a multiplex evaluated...
Abstract While significant attention has been paid to the immunologic determinants of disease states associated with COVID-19 1,2 , their contributions post-acute sequelae (PASC) remain less clear 3-5 . Due wide array PASC presentations 6 it is critical understand if specific features are discrete immune processes, and whether those processes may be therapeutically targeted. To this end, we performed serological characterization patients in early recovery phase across a breadth symptomatic...
<title>Abstract</title> Post-acute sequelae of SARS-CoV-2 (SARS2) infection (PASC) is a heterogeneous condition, but the main viral drivers are unknown. Here, we use MENSA, Media Enriched with Newly Synthesized Antibodies, secreted exclusively from circulating human plasmablasts, to provide an immune snapshot that defines underlying triggers. We proof-of-concept testing MENSA technology can capture new host response accurately diagnose acute primary and breakthrough infections when known...