A5069545555- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Advanced Chemical Physics Studies
- Atmospheric chemistry and aerosols
- Cardiac Health and Mental Health
- Cardiovascular and exercise physiology
- Stress Responses and Cortisol
- Cardiovascular Health and Disease Prevention
- Catalysis and Oxidation Reactions
- Catalytic Processes in Materials Science
- Vagus Nerve Stimulation Research
- Atmospheric Ozone and Climate
- Spectroscopy and Laser Applications
- Dialysis and Renal Disease Management
- Hormonal Regulation and Hypertension
- Mindfulness and Compassion Interventions
- Neuroscience of respiration and sleep
- Nitric Oxide and Endothelin Effects
- Advanced Combustion Engine Technologies
- Posttraumatic Stress Disorder Research
- Thermoregulation and physiological responses
- Renin-Angiotensin System Studies
- Chronic Kidney Disease and Diabetes
- Sodium Intake and Health
- Traumatic Brain Injury and Neurovascular Disturbances
Emory University
2015-2024
Atlanta VA Health Care System
2019-2024
Chonnam National University Hwasun Hospital
2023-2024
Atlanta VA Medical Center
2012-2023
Veterans Health Administration
2012-2023
University of Delaware
2023
Korea University
2010-2023
Chungnam National University
2023
Atlanta Medical Center
2020
Emory University Hospital
2020
Vascular endothelial growth factor (VEGF) and its two cell-specific receptor tyrosine kinases, Flk-1/KDR Flt-1, play a key role in physiological pathological angiogenesis. Hypoxia has been shown to be major mechanism for up-regulation of VEGF receptors vivo. When we exposed human umbilical vein cells hypoxic conditions vitro, observed increased levels Flt-1expression. In contrast, mRNA were unchanged or slightly repressed. These findings suggest differential transcriptional regulation the by...
Vascular endothelial growth factor (VEGF) expression in various cell types is induced by hypoxia and other stimuli. VEGF mediates proliferation, angiogenesis, vascular growth, permeability via the receptors, kinase insert domain-containing receptor (KDR)/fetal liver 1 (Flk-1) FLT-1. Alanine-scanning mutagenesis was used to identify a positively charged surface that binding KDR/Flk-1. Arg82, Lys84 His86, located hairpin loop, were found be critical for KDR/Flk-1, while negatively residues,...
Patients with post-traumatic stress disorder (PTSD) are at a significantly higher risk of developing hypertension and cardiovascular disease. The mechanisms underlying this increased not known. Studies have suggested that PTSD patients an overactive sympathetic nervous system (SNS) could contribute to risk; however, function has previously been rigorously evaluated in patients. Using direct measurements nerve activity pharmacological manipulation blood pressure, we show veterans augmented...
Abstract Background Muscle wasting is a common complication of chronic kidney disease (CKD) that associated with higher mortality. Although the mechanisms myofibre loss in CKD has been widely studied, contribution muscle precursor cell (MPC) senescence remains poorly understood. Senescent MPCs no longer proliferate and can produce proinflammatory factors or cytokines. In this study, we tested hypothesis secretory phenotype (SASP) contributes to CKD‐induced atrophy weakness. Methods was...
Mindfulness meditation (MM) is a stress-reduction technique that may have real biological effects on hemodynamics but has never previously been tested in chronic kidney disease (CKD) patients. In addition, the mechanisms underlying potential blood pressure (BP)-lowering of MM are unknown. We sought to determine whether acutely lowers BP CKD patients, and these hemodynamic changes mediated by reduction sympathetic nerve activity. 15 hypertensive African-American (AA) males with CKD, we...
Abstract Chronic kidney disease (CKD) is characterized by over-activation of the sympathetic nervous system (SNS) that increases cardiovascular risk. Whether baroreflex sensitivity (sBRS) impaired or intact in CKD remains under-studied and controversial. Furthermore, downstream effect SNS activation on blood pressure transduction has not been previously examined CKD. We tested hypothesis sBRS attenuated, while augmented In 18 sedentary patients with stages III-IV (eGFR: 40±14 mL/min) 13...
Chronic kidney disease (CKD) patients have exercise intolerance associated with increased cardiovascular mortality. Previous studies demonstrate that blood pressure (BP) and sympathetic nerve responses to handgrip are exaggerated in CKD. These also decreased nitric oxide (NO) bioavailability endothelial dysfunction, which could potentially lead an impaired ability vasodilate during exercise. We hypothesized CKD BP maximal whole body dysfunction correlates greater pressor these patients....
Patients with posttraumatic stress disorder (PTSD) have elevated sympathetic nervous system reactivity and impaired cardiovagal baroreflex sensitivity (BRS). Device-guided slow breathing (DGB) has been shown to lower blood pressure (BP) activity in other patient populations. We hypothesized that DGB acutely lowers BP, heart rate (HR), improves BRS PTSD. In 23 prehypertensive veterans PTSD, we measured continuous ECG, muscle nerve (MSNA) at rest during 15 min of 5 breaths/min ( n = 13) or...
Patients with chronic kidney disease (CKD) and end-stage (ESKD) experience an increased risk of cerebrovascular cognitive dysfunction. Hemodialysis (HD), a major modality renal replacement therapy in ESKD, can cause rapid changes blood pressure, osmolality, acid-base balance that collectively present unique stress to the cerebral vasculature. This review presents update regarding flow (CBF) regulation CKD ESKD how maintenance oxygenation may be compromised during HD. exhibit decreased oxygen...
Posttraumatic stress disorder (PTSD) is a highly disabling condition associated with alterations in multiple neurobiological systems, including increases inflammatory and sympathetic function, responsible for maintenance of symptoms. Treatment options medications psychotherapies have limitations. We previously showed that transcutaneous Vagus Nerve Stimulation (tcVNS) blocks (interleukin (IL)-6) responses to PTSD. The purpose this study was assess the effects tcVNS on PTSD symptoms stress....
The kinetics of the metathetical reaction phenyl radical with methane has been studied theoretically and experimentally. rate constants determined by two complementary methods, pyrolysis/Fourier transform infrared spectrometry pulsed laser photolysis/mass in temperature range 600−980 K, give Arrhenius equation: k1 = 1012.78 ± 0.13 exp[(−6201 225)/T] cm3/(mol s). At best theoretical level employed (G2M(CC,MP2)), barrier for at 0 K is E10 9.3 kcal/mol. constant calculated from molecular...
End-stage renal disease (ESRD) is characterized by resting sympathetic overactivity. Baseline muscle nerve activity (MSNA), which governed baroreflexes and chemoreflexes, elevated in ESRD. Whether skin (SSNA), independent from baroreflex chemoreflex control, also has never been reported failure. The purpose of this study was to determine whether overactivity ESRD generalized include the distribution. We measured both using microneurography eight patients controls. MSNA significantly (P =...
Overweight individuals (body mass index (BMI) 25–29.9 kg/m2) are at higher risk for developing cardiovascular disease and hypertension when compared with lean of normal weight (BMI 18.5–24.9 kg/m2). The purpose this study was to test the hypothesis that exaggerated sympathetic nervous system responses stressors may be one potential mechanism predisposes overweight hypertension. We heart rate (HR), blood pressure (BP), muscle nerve activity (MSNA) using microneurography, in normotensive...
Prehypertension is associated with increased cardiovascular morbidity and mortality. However, there are few population-based studies on the changes of structure function that characterize prehypertension. The aim this study was to assess whether prehypertension abnormalities in general Korean population. We analyzed cross-sectional relationships between a sample from Genome Epidemiology Study. A total 1,671 individuals (54.5% women; mean age: 53 ± 6 years) without hypertension diabetes...
Patients with chronic kidney disease are at significantly increased risk for cardiovascular and sudden cardiac death. One mechanism underlying in patients renal failure includes overactivation of the sympathetic nervous system (SNS). Multiple human animal studies have shown that central outflow is chronically elevated both end-stage (ESRD) (CKD). SNS overactivation, turn, increases death by increasing arterial blood pressure, arrythmogenicity, left ventricular hypertrophy, coronary...
Elevated nocturnal blood pressure (BP) and non-dipping are frequently observed in patients with chronic kidney disease (CKD) stronger predictors of cardiovascular complications CKD progression than standard office BP. The sympathetic nervous system (SNS) is thought to modulate diurnal hemodynamic changes the vascular endothelium plays a fundamental role BP regulation. We hypothesized that SNS overactivity endothelial dysfunction linked elevated non-dipping. In 32 hypertension (56 ± 7 years),...
Patients with chronic kidney disease (CKD) exhibit increased blood pressure reactivity during exercise that is associated endothelial dysfunction. Twelve weeks of structured, aerobic, training improves function and attenuates peak responses in CKD stages III–IV.