A5102763949- Mechanical Circulatory Support Devices
- Blood transfusion and management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac Arrest and Resuscitation
- Platelet Disorders and Treatments
- Sepsis Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Neonatal Respiratory Health Research
- Cardiac Structural Anomalies and Repair
- Blood Coagulation and Thrombosis Mechanisms
- Neonatal Health and Biochemistry
- Atrial Fibrillation Management and Outcomes
- Respiratory Support and Mechanisms
- Heart Failure Treatment and Management
- Hemostasis and retained surgical items
- Blood properties and coagulation
- Blood groups and transfusion
- Childhood Cancer Survivors' Quality of Life
- Trauma and Emergency Care Studies
- Hemophilia Treatment and Research
- Hematopoietic Stem Cell Transplantation
- Cardiac and Coronary Surgery Techniques
- Hemoglobinopathies and Related Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Kawasaki Disease and Coronary Complications
University of Minnesota
2016-2025
University of Minnesota Children's Hospital
2007-2024
University of Minnesota Medical Center
2005-2024
University Hospital of Bern
2024
University of Bern
1986-2024
Fairview Health Services
2019-2024
Boston Children's Hospital
2017-2024
Boston University
2024
Robert Bosch (Germany)
2023
University of Arkansas for Medical Sciences
2022
Some observational studies have reported that transfusion of red-cell units been stored for more than 2 to 3 weeks is associated with serious, even fatal, adverse events. Patients undergoing cardiac surgery may be especially vulnerable the effects transfusion.We conducted a randomized trial at multiple sites from 2010 2014. Participants 12 years age or older who were complex and likely undergo red cells randomly assigned receive leukocyte-reduced 10 days less (shorter-term storage group) 21...
Objectives: To date, there are no published guidelines to direct RBC transfusion decision-making specifically for critically ill children. We present the recommendations from Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Design: Consensus conference series of multidisciplinary, international experts in management Setting: Not applicable. Intervention: None. Subjects: Children with, or children at risk for, critical illness who receive receiving a transfusion. Methods:...
Formation of lipid peroxides rises sharply when platelets undergo the release reaction. In this study in vitro effect vitamin E on platelet aggregation was investigated. alpha-Tocopherol, an anitoxidant known inhibitory action peroxidation, added to suspensions concentrations up 1.5 mM. A dose-dependent reduction observed, with complete inhibition secondary wave at greater than or equal 0.9 mM alpha-tocopherol. The alpha-tocopherol reaction further documented by decrease aggregation-induced...
Despite improved diagnostics, pulmonary pathogens in immunocompromised children frequently evade detection, leading to significant mortality. Therefore, we aimed develop a highly sensitive metagenomic next-generation sequencing (mNGS) assay capable of evaluating the microbiome and identifying diverse lungs children.We collected 41 lower respiratory specimens from 34 undergoing evaluation for disease at 3 children's hospitals 2014-2016. Samples underwent mechanical homogenization, parallel...
To address the clinical and regulatory challenges of optimal primary endpoints for bleeding patients by developing consensus-based recommendations outcomes pivotal trials in within 6 categories significant bleeding, (1) traumatic injury, (2) intracranial hemorrhage, (3) cardiac surgery, (4) gastrointestinal (5) inherited disorders, (6) hypoproliferative thrombocytopenia.A standardized outcome evaluating hemostatic products strategies treatment clinically will facilitate conduct,...
<h3>Importance</h3> The clinical consequences of red blood cell storage age for critically ill pediatric patients have not been examined in a large, randomized trial. <h3>Objective</h3> To determine if the transfusion fresh cells (stored ≤7 days) reduced new or progressive multiple organ dysfunction syndrome compared with use standard-issue children. <h3>Design, Setting, and Participants</h3> Age Transfused Blood Critically-Ill Children trial was an international, multicenter, blinded,...
The purpose of our study was to describe children with life-threatening bleeding.We conducted a prospective observational bleeding events.Twenty-four childrens hospitals in the United States, Canada, and Italy participated.Children 0-17 years old who received greater than 40 mL/kg total blood products over 6 hours or were transfused under massive transfusion protocol included.Children compared according etiology: trauma, operative, medical.Patient characteristics, therapies administered,...
Background Patients with single-ventricle physiology who undergo the Fontan procedure are at risk for thrombotic events associated significant morbidity and mortality. The UNIVERSE Study evaluated efficacy safety of a novel liquid rivaroxaban formulation, using body weight-adjusted dosing regimen, versus acetylsalicylic acid (ASA) in children post-Fontan. Methods Results was randomized, multicenter, 2-part, open-label study rivaroxaban, had undergone procedure, to evaluate its safety,...
Inherited and acquired coagulopathy are frequently associated with major bleeding in severe trauma, cardiac surgery cardiopulmonary bypass, postpartum hemorrhage. Perioperative management is multifactorial includes preoperative optimization discontinuation of anticoagulants antiplatelet therapy elective procedures. Prophylactic or therapeutic use antifibrinolytic agents strongly recommended guidelines has been shown to reduce need for allogeneic blood administration. In the context induced...
Cardiac surgery is the most common setting for massive transfusion in medically advanced countries. Studies of after injury suggest that ratios administered plasma and platelets (PLT) to red blood cells (RBCs) affect mortality. Data from Red Cell Storage Duration Study (RECESS), a large randomized trial effect RBC storage duration patients undergoing complex cardiac surgery, were analyzed retrospectively investigate association between component used massively transfused subsequent clinical...
Little is known about platelet transfusions in pediatric critical illness. We sought to describe the epidemiology, indications, and outcomes of among critically ill children.Prospective cohort study.Multicenter (82 PICUs), international (16 countries) from September 2016 April 2017.Children ages 3 days 16 years prescribed a transfusion ICU during screening days.None.Over 6 weeks, 16,934 patients were eligible, 559 received at least one (prevalence, 3.3%). The indications for included...