A5042344882- Congenital Heart Disease Studies
- Cardiovascular Issues in Pregnancy
- Cardiovascular Function and Risk Factors
- Birth, Development, and Health
- Congenital heart defects research
- Congenital Diaphragmatic Hernia Studies
- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Innovations in Medical Education
- Atrial Fibrillation Management and Outcomes
- Tracheal and airway disorders
- Cardiovascular and Diving-Related Complications
- Muscle Physiology and Disorders
- Coronary Artery Anomalies
- Neonatal Respiratory Health Research
- Cardiovascular Conditions and Treatments
- Gestational Diabetes Research and Management
- Health and Medical Research Impacts
- Maternal Mental Health During Pregnancy and Postpartum
- Adipose Tissue and Metabolism
- Vascular anomalies and interventions
- Cardiomyopathy and Myosin Studies
- Infective Endocarditis Diagnosis and Management
University of Iowa
2013-2025
University of Iowa Hospitals and Clinics
2013-2024
University of Iowa Stead Family Children’s Hospital
2013-2023
Instituto Benjamin Constant
2015
Society of Thoracic Surgeons
2013
National Institutes of Health
2013
Boston Children's Hospital
2012
National Defense Medical Center
2010
Wayne State University
2010
Background Patients with single-ventricle physiology who undergo the Fontan procedure are at risk for thrombotic events associated significant morbidity and mortality. The UNIVERSE Study evaluated efficacy safety of a novel liquid rivaroxaban formulation, using body weight-adjusted dosing regimen, versus acetylsalicylic acid (ASA) in children post-Fontan. Methods Results was randomized, multicenter, 2-part, open-label study rivaroxaban, had undergone procedure, to evaluate its safety,...
The Xin repeat-containing proteins mXinalpha and mXinbeta localize to the intercalated disc of mouse heart are implicated in cardiac development function. directly interacts with beta-catenin, p120-catenin, actin filaments. Ablation results adult late-onset cardiomyopathy conduction defects. An upregulation mXinalpha-deficient hearts suggests a partial compensation.The essential roles maturation were investigated.Ablation led abnormal shape, ventricular septal defects, severe growth...
Cardiac septal overgrowth complicates 10–40% of births from diabetic mothers, but perplexingly hyperglycemia markers during pregnancy are not reliably predictive. We thus tested whether fetal exposure to is sufficient induce cardiac even in the absence systemic maternal diabetes. To isolate effects hyperglycemia, we infused glucose into blood supply left right uterine horn nondiabetic pregnant rats starting on gestational day 19. After 24 h infusion, right-sided fetuses and dams remained...
Abstract Background Maternal diabetes affects the developing fetal cardiovascular system. Newborn offspring of diabetic mothers can have a transient cardiomyopathy. We hypothesized that cardiomyopathic remodeling is associated with activation mitogen activated protein kinase (MAPK) signaling and apoptotic pathways. Methods To evaluate effects moderate severe maternal hyperglycemia, pregnant rats were made an injection 50 mg/kg streptozotocin. Moderately well controlled was achieved twice...
Reported frequencies of cardiomyopathy in limb girdle muscular dystrophy R9 (LGMDR9) vary. We describe the frequency and age at onset an LDMDR9 cohort.Echocardiograms from 56 subjects (157 echocardiograms) with LGMDR9 were retrospectively reviewed. The cumulative probability having abnormal echocardiogram as a function was assessed by survival analysis for interval-censored data genotype. Correlations between cardiac clinical evaluated.Twenty-five (45%) participants had cardiomyopathy....
<i>Background:</i> In utero exposure to hyperglycemia is becoming increasingly prevalent as the number of women entering pregnancy with type II diabetes, or developing gestational increases. Both animal studies and epidemiologic investigations have found cardiovascular abnormalities in adult offspring hyperglycemic mothers (OHM). <i>Objective:</i> We hypothesized that OHM would abnormal cardiac function vivo increased susceptibility ischemia....
Selective serotonin reuptake inhibitors are prescribed to 6%-10% of pregnant women in the United States. Using an intrauterine plus neonatal exposure model represent throughout human pregnancy, we hypothesized sertraline would impact intracardiac signaling and lead small left heart syndrome absence maternal psychopathology. C57BL/6 adult female mice received (5 mg·kg·d IP) or saline pregnancy time delivery. Pups maintained on postnatal days 1-14 encompass developmental window analogous...
Background As a result of medical and surgical advancements in the management congenital heart disease (CHD), survival rates have improved substantially, which has allowed focus CHD to shift toward neurodevelopmental outcomes. Previous studies neuropathology occurring focused on cases preceding 1995 reported high white matter injury intracranial hemorrhage, but do not reflect improvements past 2 decades. The purpose this study is therefore characterize neuropathological lesions identified...
Acquired intracardiac left-to-right shunts are rare occurrences. Chest trauma and myocardial infection well-known causes of acquired ventricular septal defect (VSD). There have been several case reports describing left ventricle to right atrium shunt after infective endocarditis (IE). We present here a patient found an VSD secondary IE the aortic tricuspid valves in setting known bicuspid valve. This is first reported pediatric along with literature review shunts.
A mycotic aneurysm is a rare condition occasionally seen in patients with history of prior cardiac or vascular surgery. Here we report the presentation pediatric patient at site aortic coarctation repair. This patient's initial suggested rheumatologic oncologic disease, and after diagnosis he continued to show evidence splenic, renal injury distal while being treated antibiotics. We discuss diagnosis, treatment management this condition.
Maximal tetanic tension was elicited at 200, 150, and 150 Hz in control tibialis anterior muscles 100, 100 14-day regenerating of young (3 months), adult (18 old (31 months) Fischer 344/Brown Norway F1 rats, respectively. In contrast to increasing stimulation frequency from 50 did not elicit significantly greater or rats. At higher frequencies, fade prevalent (250–300 Hz) rats (200–300 Hz), but only present 14 days recovery (300 Hz). The decreased efficacy rehabilitative physical medicine...
We present a rare case of single pulmonary venous trunk that drains all segments to the left atrium. This anomaly may mimic arteriovenous malformation on imaging. report briefly discusses embryology veins and classification anomalies.
<b><i>Background:</i></b> Selective serotonin reuptake inhibitors (SSRIs) are antidepressants prescribed in 10% of pregnancies the USA. We have previously shown preclinical studies that sertraline exposure impacts cardiomyocyte development, leading to reductions left ventricular size and cardiac function. <b><i>Objectives:</i></b> hypothesized utero SSRI will lead reduced dimensions function on echocardiography immediately after birth....
Perinatal growth restriction (GR) is associated with heightened sympathetic tone and hypertension. We have previously shown that naturally occurring neonatal GR programmes hypertension in male but not female mice. therefore hypothesized intact ovarian function or post-ovariectomy (OVX) oestrogen administration protects mice from Utilizing a non-interventional model categorizes weanling weights below the tenth percentile as GR, control adult were studied at three distinct time points:...
A 6-year-old male child born with hypoplastic left heart syndrome (HLHS) was palliated an extracardiac nonfenestrated Fontan procedure (18-mm Gore-Tex tube graft). He developed low-pressure (mean pressure 10 mmHg) protein-losing enteropathy 6 months after palliation. After initially responding to medical therapy and transcatheter pulmonary artery stent implantation, he medically refractory enteropathy. At this time, his transthoracic echocardiogram showed new restriction across native atrial...
Abstract Introduction: Congenital heart disease (CHD) is multifactorial in origin, resulting from an interaction between environmental and genetic factors. Multifactorial growth delay common infants with CHD. The impact of a abnormality CHD on the infant lacking literature. aim this study to compare method feeding following neonatal cardiac surgery normal versus abnormal testing. Methods: A retrospective chart review neonates who underwent Risk Adjustment Heart Surgery IV–VI procedure 1...