Kailash Chander Aggarwal

ORCID: 0000-0002-5343-1491
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About
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Research Areas
  • Neonatal Respiratory Health Research
  • Global Maternal and Child Health
  • Child Nutrition and Water Access
  • Infective Endocarditis Diagnosis and Management
  • Bacterial Identification and Susceptibility Testing
  • Diphtheria, Corynebacterium, and Tetanus
  • Neonatal and Maternal Infections
  • Birth, Development, and Health
  • Tumors and Oncological Cases
  • Mosquito-borne diseases and control
  • Viral gastroenteritis research and epidemiology
  • Immune Cell Function and Interaction
  • Tuberculosis Research and Epidemiology
  • Neonatal Health and Biochemistry
  • Genetic and rare skin diseases.
  • Airway Management and Intubation Techniques
  • Botulinum Toxin and Related Neurological Disorders
  • Infant Nutrition and Health
  • T-cell and B-cell Immunology
  • Trace Elements in Health
  • Iron Metabolism and Disorders
  • Gestational Diabetes Research and Management
  • Injury Epidemiology and Prevention
  • Infant Development and Preterm Care
  • Hematological disorders and diagnostics

Sarojini Naidu Medical College
2024

Vardhman Mahavir Medical College & Safdarjung Hospital
2013-2022

Santosh University
2022

Safdarjang Hospital
2001-2021

University of Ghana
2021

University of Malawi
2021

Muhimbili National Hospital
2021

World Health Organization
2021

SRM University
2019

Post Graduate Institute of Medical Education and Research
1980

Background There is a paucity of data on the epidemiology sepsis in outborn neonates being referred to level-3 units low- and middle-income countries (LMIC). The objective present study was evaluate prevalence outcomes with sepsis, characterize pathogen profile antimicrobial resistance (AMR) patterns common isolates them. Methods In this prospective observational cohort (2011–2015), dedicated research team enrolled all admitted an neonatal unit followed them until discharge/death. Sepsis...

10.1371/journal.pone.0180705 article EN cc-by PLoS ONE 2018-06-28

The human peripheral leukocyte subset composition depends on genotype variation and pre-natal post-natal environmental influence diversity. We quantified this in adults neonates, compared the median values dispersal ranges of various subsets them. confirmed higher frequencies monocytes regulatory T cells (Tregs), similar neutrophils, lower CD8 cells, NKT B1 B gamma-delta neonatal umbilical cord blood. Unlike previous reports, we found eosinophils CD4:CD8 ratios, iNKT CD4 NK neonates....

10.1371/journal.pone.0162242 article EN cc-by PLoS ONE 2016-09-09

Background Neonatal sepsis is a major cause of death in India, which needs hospital management but many families cannot access hospitals. The World Health Organization and the Government India developed guideline to manage possible serious bacterial infection (PSBI) when referral not feasible. We implemented this achieve high coverage treatment PSBI with low mortality. Methodology implementation research study was conducted over 50 villages Palwal district, Haryana during August 2017-March...

10.1371/journal.pone.0252700 article EN cc-by PLoS ONE 2021-07-07

Enterococci are part of the normal intestinal flora and have been recognized as important human pathogens. Vancomycin Resistant (VRE) global threat this resistance is transmissible also poses a challenge for infection control.This study was undertaken to phenotypic genotypic characteristics VRE from clinically significant infections among hospitalized patients their association with gut colonization.Clinically isolates enterococci (n=250) were studied. Species confirmation done by Polymerase...

10.7860/jcdr/2017/25988.10548 article EN cc-by-nc-nd JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH 2017-01-01

Low/middle-income countries need a large-scale improvement in the quality of care (QoC) around time childbirth order to reduce high maternal, fetal and neonatal mortality. However, there is paucity scalable models.We conducted stepped-wedge cluster-randomised trial 15 primary health centres (PHC) state Haryana India test effectiveness multipronged management strategy comprising capacity building providers, periodic assessments PHCs identify gaps undertaking activities for closure gaps. The...

10.1136/bmjgh-2018-000907 article EN cc-by-nc BMJ Global Health 2018-10-01

To compare immune phenotypes across two geographic and ethnic communities, we examined umbilical cord blood by flow cytometry Luminex in parallel cohorts of 53 newborns from New Delhi, India, 46 Stanford, California. We found that frequencies a B cell subset suggested to be B-1-like, serum IgM concentration were both significantly higher the Stanford cohort, independent differences maternal age. While IgA levels also IgG1, IgG2, IgG4 Delhi samples. neutrophils, plasmacytoid dendritic cells,...

10.1371/journal.pone.0207297 article EN cc-by PLoS ONE 2018-11-16

Background: This study was done to evaluate the effect of maternal anaemia and its severity on gestational age neonatal outcome.Methods: a retrospective study, conducted in Vardhman Mahavir medical college Safdarjang hospital, New Delhi between April 2012 March 2013. Cases were divided three groups i.e. non anaemic, mild moderately anaemic severely (according WHO classification). A total 1050 woman (350 each group) recruited for study. The following outcome measures used: preterm delivery...

10.5455/2320-1770.ijrcog20140607 article EN International Journal of Reproduction Contraception Obstetrics and Gynecology 2014-01-01

Background While infections are a major cause of neonatal mortality in India even full-term neonates, this is an especial problem the large proportion (~20%) neonates born underweight (or small-for-gestational-age; SGA). One potential contributory factor for susceptibility possibility that immune system maturation may be affected along with intrauterine growth retardation. Methods In order to examine differences status underlie SGA infections, we enumerated frequencies and concentrations 22...

10.1371/journal.pone.0123589 article EN cc-by PLoS ONE 2015-04-21

We conducted a study to find relationship between main weather parameters with admission of positive dengue cases in tertiary hospital.Retrospective analysis was undertaken identify epidemiological trend 2016 from paediatric wards hospital New Delhi. Data were collected on patient particulars and daily January December 2016.A total 266 confirmed considered. Relative humidity (RH) associated burden cases. On week-wise analysis, each surge preceded by heavy rain 4-6 weeks earlier. Monthly...

10.1093/tropej/fmx077 article EN Journal of Tropical Pediatrics 2017-09-29

An estimated 2.7 of the 5.9 million deaths in children under 5 years age occur neonatal period. Severe infections contribute to almost a quarter these deaths. Mortality due severe developing country settings is substantial despite antibiotic therapy. Effective interventions that can be added standard therapy for are required reduce case fatality. This double-blind randomized placebo-controlled parallel group superiority trial investigate effect zinc administered orally as an adjunct infants...

10.1186/s40360-017-0162-5 article EN cc-by BMC Pharmacology and Toxicology 2017-07-10

The diagnosis of Central Nervous System tuberculosis (CNS TB) had been always an enigma as yield Mycobacterium in cerebrospinal fluid (CSF) is very low and mainly rested on combination clinical, CSF analysis radiological findings. We attempted to find whether 16s rRNA primer based real time Polymerase chain reaction (PCR) aids tubercular meningitis (TBM) tuberculoma. Literature flooded with newer techniques for the neuro-tuberculosis by PCR. But no clear cut guidelines are available about...

10.3233/jpi-120362 article EN Journal of Pediatric Infectious Diseases 2015-07-28
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