A5002972800- Infant Development and Preterm Care
- Neonatal Respiratory Health Research
- Global Maternal and Child Health
- Child Nutrition and Water Access
- Breastfeeding Practices and Influences
- Family and Patient Care in Intensive Care Units
- Neonatal and Maternal Infections
- Respiratory Support and Mechanisms
- Delphi Technique in Research
- COVID-19 Impact on Reproduction
- Congenital Diaphragmatic Hernia Studies
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Vaccine Coverage and Hesitancy
- Malaria Research and Control
- Antibiotic Use and Resistance
- Mosquito-borne diseases and control
- Neuroscience of respiration and sleep
- Neonatal and fetal brain pathology
- Neonatal Health and Biochemistry
- Child and Adolescent Health
- Hemoglobinopathies and Related Disorders
- Child Nutrition and Feeding Issues
- Bacterial Identification and Susceptibility Testing
- Maternal Mental Health During Pregnancy and Postpartum
Kamuzu Central Hospital
2022-2025
Kamuzu University of Health Sciences
2022-2025
Queen Elizabeth Central Hospital
2014-2025
University of Malawi
2013-2024
University of Health Science
2023-2024
Center for Assessment
2024
Malawi-Liverpool-Wellcome Trust Clinical Research Programme
2012-2024
University of Liverpool
2012-2024
Liverpool School of Tropical Medicine
2022
Wellcome Sanger Institute
2022
“Kangaroo mother care,” a type of newborn care involving skin-to-skin contact with the or other caregiver, reduces mortality in infants low birth weight (<2.0 kg) when initiated after stabilization, but majority deaths occur before stabilization. The safety and efficacy kangaroo soon among are uncertain.
BackgroundCerebral malaria, a disorder characterised by coma, parasitaemia, and no other evident cause of is challenging to diagnose definitively in endemic regions that have high rates asymptomatic parasitaemia limited neurodiagnostic facilities. A recently described malaria retinopathy improves diagnostic specificity. We aimed establish whether retinopathy-positive cerebral risk factor for epilepsy or neurodisabilities.MethodsBetween 2005 2007, we did prospective cohort study survivors...
Background Respiratory failure is a leading cause of neonatal mortality in the developing world. Bubble continuous positive airway pressure (bCPAP) safe, effective intervention for infants with respiratory distress and widely used developed countries. Because its high cost, bCPAP not utilized low-resource settings. We evaluated performance new system to treat severe low resource setting, comparing it nasal oxygen therapy, current standard care. Methods conducted non-randomized convenience...
COVID-19 is disrupting health services for mothers and newborns, particularly in low- middle-income countries (LMIC). Preterm newborns are vulnerable. We undertook analyses of the benefits kangaroo mother care (KMC) on survival among neonates weighing ≤2000 g compared with risk SARS-CoV-2 acquired from infected mothers/caregivers.We modelled two scenarios over 12 months. Scenario 1 KMC universal coverage (99%) mortality due to COVID-19. 2 estimated incremental deaths reduced complete...
The adequacy of the World Health Organization's Integrated Management Childhood Illness (IMCI) antimicrobial guidelines for treatment suspected severe bacterial infections is dependent on a low prevalence resistance (AMR). We describe trends in etiologies and susceptibility patterns bloodstream (BSI) hospitalized children Malawi.We determined change population-based incidence BSI admitted to Queen Elizabeth Central Hospital, Blantyre, Malawi (1998-2017). AMR profiles were assessed by disc...
Acute respiratory infections are the leading cause of global child mortality. In developing world, nasal oxygen therapy is often only treatment option for babies who suffering from distress. Without added pressure bubble Continuous Positive Airway Pressure (bCPAP) which helps maintain alveoli open, struggle to breathe and can suffer serious complications, frequently death. A stand-alone bCPAP device cost $6,000, too expensive most world hospitals. Here, we describe design technical...
BackgroundTo implement the immediate Kangaroo mother care (iKMC) intervention in previous multicentre, open-label, randomised controlled trial, or a surrogate caregiver and neonate needed to be together continuously, which led concept of Mother–Newborn Care Unit (MNCU). Health-care providers administrators were concerned potential increase infections caused by continuous presence mothers surrogates MNCU. We aimed assess incidence neonatal sepsis sub-groups bacterial profile among control...
Bacteria of the order Enterobacterales are common pathogens causing bloodstream infections in sub-Saharan Africa and frequently resistant to third-generation cephalosporin antibiotics. Although resistance is believed lead adverse outcomes, this relationship difficult quantify has rarely been studied region. We aimed measure effects associated with cephalosporins hospitalised patients infection Africa.
Abstract Background Each year an estimated 2.3 million newborns die in the first 28 days of life. Most these deaths are preventable, and high-quality neonatal care is fundamental for surviving thriving. Service readiness used to assess capacity hospitals provide care, but current health facility assessment (HFA) tools do not fully evaluate inpatient small sick newborn (SSNC). Methods Health systems ingredients SSNC were identified from international guidelines, notably World Organization...
Abstract Background Infections caused by multidrug-resistant gram-negative bacteria present a severe threat to global public health. The WHO defines drug-resistant Klebsiella pneumoniae as priority pathogen for which alternative treatments are needed given the limited treatment options and rapid acquisition of novel resistance mechanisms this species. Longitudinal descriptions genomic epidemiology can inform management strategies but data from sub-Saharan Africa lacking. Methods We...
Patients surviving retinopathy-positive cerebral malaria (CM) are at high risk for the development of epilepsy, developmental disabilities, and behavioral abnormalities. We aimed to establish whether retinopathy-negative CM is also a factor these outcomes.Between 2005 2007, survivors concurrently hospitalized controls in Blantyre, Malawi, were followed assess neurologic At discharge every 3 months thereafter, incident cases epilepsy disabilities ascertained using screening questionnaires...
Background Preterm birth complications are the leading cause of neonatal deaths. Malawi has high rates preterm birth, with 18.1 births per 100 live births. More than 50% neonates develop respiratory distress which if left untreated, can lead to failure and death. Term often be effectively managed Continuous Positive Airway Pressure (CPAP) this is considered an essential intervention for management by World Health Organization. Bubble CPAP may represent a safe cost-effective method delivering...
Acute bacterial meningitis (ABM) causes significant death and disability in children worldwide, with HIV recognized as an established risk factor for infection negative outcomes. However, additional major factors pediatric ABM remain unclear.
A low-cost bubble continuous positive airway pressure (bCPAP) device has been shown to be an excellent clinical alternative nasal oxygen for the care of neonates with respiratory difficulty. However, delivery bCPAP requires more resources than current routine using oxygen. We performed economic evaluation determine cost-effectiveness a in providing ventilatory support Malawi. used patient-level data from previously published non-randomized controlled study. Economic were based on purchase...