A5033401203- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Global Maternal and Child Health
- Pneumonia and Respiratory Infections
- Hepatitis B Virus Studies
- Nosocomial Infections in ICU
- Escherichia coli research studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Probiotics and Fermented Foods
- Viral gastroenteritis research and epidemiology
- Salmonella and Campylobacter epidemiology
- Animal Virus Infections Studies
- Hepatitis Viruses Studies and Epidemiology
- Neonatal and Maternal Infections
Centre for Infectious Disease Research in Zambia
2017-2023
Bacteria of the order Enterobacterales are common pathogens causing bloodstream infections in sub-Saharan Africa and frequently resistant to third-generation cephalosporin antibiotics. Although resistance is believed lead adverse outcomes, this relationship difficult quantify has rarely been studied region. We aimed measure effects associated with cephalosporins hospitalised patients infection Africa.
Background Enterotoxigenic Escherichia coli (ETEC) is a significant cause of diarrheal disease, particularly in low—and middle-income countries, including Zambia. ETEC pathogenesis driven by colonisation factors (CF) and enterotoxins, increasing antimicrobial resistance compounds the global health burden. Despite its impact, limited genomic data exists for strains Sub-Saharan Africa. Methods This study conducted whole-genome sequencing 62 isolates collected from children under five years old...
<ns4:p><ns4:bold>Background:</ns4:bold> Bloodstream infections caused by Enterobacterales show high frequency of antimicrobial resistance (AMR) in many Low- and Middle-Income Countries. We aimed to describe the variation circumstances for management such resistant a group African public-sector hospitals participating major research study.</ns4:p><ns4:p> <ns4:bold>Methods: </ns4:bold>We gathered data from eight across sub-Saharan Africa hospital services, infection prevention antibiotic...
The occurrence of rotavirus (RV) infection among vaccinated children in high-burden settings poses a threat to further disease burden reduction. Genetically altered viruses have the potential evade both natural and vaccine-induced immune responses, leading diarrheal diseases children. Studies characterizing RV strains responsible for breakthrough infections resource-limited countries where RV-associated are endemic limited. We aimed characterize detected fully residing Zambia using...
<h3>Background</h3> This study was conducted as part of an assessment the effectiveness existing hygiene and sanitation practices in two first-level hospitals Lusaka central clinics Ndola to determine drug resistance patterns potential pathogens health care facilities Zambia. <h3>Methods</h3> In this cross-sectional study, samples analysed were collected from workers9 hands, touch surfaces, disinfectant buckets delivery rooms, post-natal paediatric wards, operation theatre, post-operation...
Background: Enterobacterales are common pathogens causing bloodstream infection (BSI) in sub-Saharan Africa and frequently resistant to 3rd generation cephalosporin (3GC) antibiotics. Although 3GC-resistance is believed lead adverse outcomes, this relationship difficult quantify has rarely been studied region. Methods: We conducted a prospective matched parallel cohort study of impacts BSI at eight hospitals across Africa. included all age-groups each patient ≥1 uninfected patients. analyzed...
Abstract Background: Bloodstream infections caused by Enterobacterales show high frequency of antimicrobial resistance (AMR) in many Low- and Middle-Income Countries. We aimed to describe the variation circumstances for management such resistant public-sector hospitals across sub-Saharan Africa. Methods: gathered data from eight Africa hospital services, infection prevention antibiotic stewardship activities, using two WHO-generated tools. collected monthly cross-sectional on availability...
Abstract Background: Bloodstream infections caused by Enterobacterales show high frequency of antimicrobial resistance (AMR) in many Low- and Middle-Income Countries. We aimed to describe the variation circumstances for management such resistant a group African public-sector hospitals participating major research study. Methods: gathered data from eight across sub-Saharan Africa hospital services, infection prevention antibiotic stewardship activities, using two WHO-generated tools....