A5065092768- Neonatal and Maternal Infections
- Antibiotic Use and Resistance
- Omental and Epiploic Conditions
- Intestinal and Peritoneal Adhesions
- Antibiotic Resistance in Bacteria
- Central Venous Catheters and Hemodialysis
- Wound Healing and Treatments
- Nosocomial Infections in ICU
- Sepsis Diagnosis and Treatment
- Pressure Ulcer Prevention and Management
- Urinary Tract Infections Management
- Neonatal skin health care
- Infection Control in Healthcare
- Case Reports on Hematomas
- Abdominal vascular conditions and treatments
- Global Maternal and Child Health
- Streptococcal Infections and Treatments
- Pharmaceutical studies and practices
- Antimicrobial Resistance in Staphylococcus
Stellenbosch University
2022-2025
Western Cape Department of Health
2022-2024
Karl Bremer Hospital
2021
Bacteria of the order Enterobacterales are common pathogens causing bloodstream infections in sub-Saharan Africa and frequently resistant to third-generation cephalosporin antibiotics. Although resistance is believed lead adverse outcomes, this relationship difficult quantify has rarely been studied region. We aimed measure effects associated with cephalosporins hospitalised patients infection Africa.
Abstract Background Neonatal sepsis is a leading cause of death in low- and middle- income countries (LMIC). Increasing antibiotic resistance early onset (< 72 h life) bloodstream infection (EO-BSI) pathogens LMIC has reduced the effectiveness recommended empiric regimen (ampicillin plus gentamicin). Methods We retrospectively analysed blood culture-confirmed EO-BSI episodes at nine neonatal units from three central six peripheral hospitals Western Cape Province, South Africa between 1...
Background: Vancomycin is a glycopeptide antibiotic that has been used to treat hospital-acquired gram-positive infections for more than 5 decades. However, the literature divided regarding therapeutic advantages of vancomycin loading doses in neonates. Objectives: This study aimed investigate effect on target attainment neonates with sepsis. Methods: A retrospective cohort was conducted compare (area under curve 0–24 hours/minimum inhibitory concentration ≥400) before and after 2019 change...
Background: Short peripheral catheter (SPC)-associated complications occur frequently in hospitalised neonates. Few studies have reported the use of SPC care bundles resource-limited neonatal units. Objective: To evaluate impact a bundle on associated (infiltration, dislodgement, phlebitis) and dwell time. Methods: We conducted quasi-experimental study comparing during 2-month baseline intervention period, where was introduced including hand hygiene, insertion site antisepsis, nurse...
Abstract Background Reports of healthcare-associated bloodstream infection (HA-BSI) epidemiology in African neonatal units are limited. Methods We conducted a cross-sectional study (2017–2018) nine the Western Cape Province, South Africa, including central, regional and district hospitals (416 beds) using laboratory clinical records. Patient demographics, HA-BSI rates, pathogen spectrum, hospital outcomes empiric antibiotic coverage rates were determined. Results Over two years, 23,748...
Hand hygiene (HH) is a cornerstone of programmes to prevent healthcare associated infections (HAI) globally, but HH interventions are seldom reported from African neonatal units.We conducted quasi-experimental study evaluating the impact multi-modal intervention (SafeHANDS) on compliance rates, alcohol-based handrub (ABHR) usage, Hygiene Self-Assessment Framework (HHSAF) score, and healthcare-associated bloodstream infection (HA-BSI) rates at 132-bed South unit (4 wards 1 intensive care...
SUMMARY In non-specific abdominal pain, cross-sectional imaging, often valued more than clinical examination in today's technologically advanced age, may reveal a large incidentaloma, posing questions regarding its relation to symptoms and the need for surgical removal. This is situation that highlights potential early detection treatment yet raises question as whether surgery indeed indicated. report relates case of 79-year-old male, with longstanding history who had giant loose peritoneal...
Background: Enterobacterales are common pathogens causing bloodstream infection (BSI) in sub-Saharan Africa and frequently resistant to 3rd generation cephalosporin (3GC) antibiotics. Although 3GC-resistance is believed lead adverse outcomes, this relationship difficult quantify has rarely been studied region. Methods: We conducted a prospective matched parallel cohort study of impacts BSI at eight hospitals across Africa. included all age-groups each patient ≥1 uninfected patients. analyzed...