A5042569526- NF-κB Signaling Pathways
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- SARS-CoV-2 and COVID-19 Research
- Macrophage Migration Inhibitory Factor
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- Cytokine Signaling Pathways and Interactions
- SARS-CoV-2 detection and testing
- Molecular Communication and Nanonetworks
- Adenosine and Purinergic Signaling
- Biosensors and Analytical Detection
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Vaccine Coverage and Hesitancy
- Sarcoidosis and Beryllium Toxicity Research
- Ubiquitin and proteasome pathways
- interferon and immune responses
- COVID-19 Clinical Research Studies
- Immune responses and vaccinations
- Liver Disease Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- COVID-19 Impact on Reproduction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
National Institutes of Health
2022-2023
National Institute of Immunology
2017-2023
National Institute of Allergy and Infectious Diseases
2022
University of Missouri–Kansas City
2003
Post-translational modification pathways such as SUMOylation are integral to all cellular processes and tissue homeostasis. We investigated the possible involvement of in epithelial signalling Crohn's disease (CD) ulcerative colitis (UC), two major forms inflammatory bowel (IBD). Initially a murine model IBD, induced by dextran-sulfate-sodium (DSS mice), we observed inflammation accompanied lowering global colonic epithelium. The alteration was due decrease sole SUMO E2 enzyme (Ubc9)....
The studies described here provide an analysis of the pathogenesis Blau syndrome and thereby function NOD2 as seen through lens its dysfunction resulting from Blau-associated mutations in nucleotide-binding domain (NBD). As such, this also sheds light on role risk polymorphisms LRR occurring Crohn's disease. main finding was that precipitate a loss canonical signaling via RIPK2 has two consequences: first, it results defective ligand (MDP)-mediated NF-κB activation second, disrupts...
Activation of B and T lymphocytes leads to major remodelling the metabolic landscape cells enabling their post-activation functions. However, naive also show differences, genesis, nature functional significance these differences are not yet well understood. Here we that resting B-cells appeared have lower energy demands than T-cells as they consumed levels glucose fatty acids produced less ATP. Resting more dependent on OXPHOS, while dependence aerobic glycolysis. despite an apparently...
Summary Activated T‐cells make both interleukin‐2 (IL2) and its high‐affinity receptor component CD25. Regulatory CD4 (Treg cells) do not IL2, the IL2‐CD25 circuit is considered a paracrine crucial in their generation maintenance. Yet, all are capable of making IL2 at some stage during differentiation, cell‐intrinsic autocrine additionally possible. When we re‐visited experiments with mixed bone marrow chimeras using wide range ratios wild‐type (WT) IL2−/− genotype progenitors, found that,...
Abstract The immunological roles of the nuclear factor-kappaB (NF-κB) pathway are mediated via canonical components in immune responses and non-canonical organogenesis homeostasis, although two capable crosstalk. Regulatory CD4 T cells (Tregs) homeostatically functional represent an interesting potential meeting point these NF-κB components. We show that mice deficient component gene Nfkb2 (p100) had normal thymic development suppressive function Tregs. However, they enhanced frequencies...
X-linked immune-deficient (Xid) mice, carrying a mutation in Bruton's tyrosine kinase (Btk), have multiple B cell lineage differentiation defects. We now show that, while Xid mice showed only mild reduction the frequency of late transitional (T2) stage peripheral cells, defect became severe when genotype was combined with either CD40-null, TCRbeta-null or an MHC class II (MHCII)-null genotype. Purified T1 and T2 cells survived poorly vitro compared to wild-type (WT) cells. BAFF rescued WT...
Abstract Despite the initial successes of Bacillus Calmette-Guerin (BCG) vaccine in children, its efficacy against tuberculosis is highly variable. There a lack understanding about how mental conditions influence BCG vaccination. Here, we used chronic social defeat stress (CSDS) model to explore effects depression on vaccination efficacy. We observed higher lung and spleen bacterial loads lower organ index depressed compared mice. Meanwhile, relatively T cell protective was both control mice...
Dhar, A.; Yang, R.; Gao, J. J.; Morrison, D. C.; Qureshi, N.; Ray, B. K.; Van Way, C. W. III Author Information