A5004853107- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Protein Hydrolysis and Bioactive Peptides
- Immune Response and Inflammation
- Synthesis and Characterization of Heterocyclic Compounds
- Healthcare and Venom Research
- Antimicrobial agents and applications
- Leech Biology and Applications
- Neuropeptides and Animal Physiology
- SARS-CoV-2 and COVID-19 Research
- Insect and Pesticide Research
- Bacterial biofilms and quorum sensing
- Vaccine Coverage and Hesitancy
- Facial Trauma and Fracture Management
- Polydiacetylene-based materials and applications
- Outsourcing and Supply Chain Management
- Blood Coagulation and Thrombosis Mechanisms
- Aquaculture disease management and microbiota
- COVID-19 and Mental Health
- Diverse Scientific Research Studies
- Medical Malpractice and Liability Issues
- Synthesis of heterocyclic compounds
- Virology and Viral Diseases
- Bacterial Identification and Susceptibility Testing
- Dental Implant Techniques and Outcomes
Chosun University
2018-2025
Hindu Rao Hospital
2025
Chettinad Academy of Research and Education
2017-2020
Chettinad Health City
2017-2020
Abstract Hybridizing two known antimicrobial peptides (AMPs) is a simple and effective strategy for designing agents with enhanced cell selectivity against bacterial cells. Here, we generated hybrid peptide Lf-KR in which LfcinB6 KR-12-a4 were linked Pro hinge to obtain novel AMP potent antimicrobial, anti-inflammatory, anti-biofilm activities. exerted superior cells over sheep red blood showed broad-spectrum activities (MIC: 4–8 μM) tested 12 strains retained its activity the presence of...
Here we describe the three-dimensional structure and antimicrobial mechanism of mBjAMP1, an peptide (AMP) isolated from Branchiostoma japonicum. The mBjAMP1 was determined by 2D solution NMR spectroscopy revealed a novel α-hairpinin-like scaffold stabilized intramolecular disulfide bond. showed effective growth inhibition bactericidal activities against pathogenic bacteria but not cytotoxic to mammalian cells. Antimicrobial studies using fluorescence-based experiments demonstrated that did...
The modulation of conformational flexibility in antimicrobial peptides (AMPs) has been investigated as a strategy to improve their efficacy against bacterial pathogens while reducing toxicity. Here, we synthesized library helicity-modulated peptoids by the position-specific incorporation helix-inducing monomers. displayed minimal variations hydrophobicity, which permitted specific assessment effect differences on activity and selectivity. Among moderately helical peptoids, most dramatic...
Abstract Antimicrobial peptides (AMPs) are promising agents for treating antibiotic‐resistant bacterial infections. Although discovering novel AMPs is crucial combating multidrug‐resistant bacteria and biofilm‐related infections, their clinical potential relies on precise, real‐time evaluation of efficacy, toxicity, mechanisms. Optical diffraction tomography (ODT), a label‐free imaging technology, enables visualization morphological changes, membrane damage, biofilm formation over time....
Abstract Background: The mankind has been fighting the pandemic of COVID-19 for last few years and vaccines came in as a real game changer by end 2020. World’s biggest vaccination drive was started India on January 16, 2021. A year later, were introduced adolescent population. concern over Adverse Events Following Immunization (AEFI) surfaced dampened vaccine uptake with increasing fear misinformation toward vaccination. AEFI is any untoward medical occurrence that follows immunization, not...
BMAP-18, derived from the N-terminal region of bovine myeloid antimicrobial peptide BMAP-27, demonstrates potent activity without cytotoxicity. This study aimed to compare antibacterial, antibiofilm, and anti-inflammatory properties rich in aromatic phenylalanine residues, with its aliphatic analog, BMAP-18-FL. Both BMAP-18 BMAP-18-FL exhibited equally activities against Gram-positive Gram-negative bacteria, particularly methicillin-resistant Staphylococcus aureus (MRSA) multidrug-resistant...
The emergence of multidrug-resistant pathogens necessitates the development novel antimicrobial agents. BP100, a short α-helical peptide (AMP) derived from cecropin A and melittin, has shown promise as potential therapeutic. To enhance its efficacy, we designed synthesized 16 tryptophan-substituted BP100 analogs based on helical wheel projections. Among these, BP5, BP6, BP8, BP11, BP13 exhibited 1.5- to 5.5-fold higher antibacterial activity improved cell selectivity compared BP100. These...
TZP4 is a triazine-based amphipathic polymer designed to mimic the structure found in antimicrobial peptides. showed potent activity comparable melittin against antibiotic-resistant bacteria, such as methicillin-resistant Staphylococcus aureus and multidrug-resistant Pseudomonas aeruginosa. high resistance proteolytic degradation low tendency develop drug resistance. The results from membrane depolarization, SYTOX Green uptake, flow cytometry, gel retardation revealed that mechanism of...
Abstract BP100 is a short cationic antimicrobial peptide (AMP) designed using combinatorial chemistry approach based on the cecropin A-melittin hybrid. It displays potent activity against gram-negative bacteria and low toxicity toward eukaryotic cells. To develop AMP with cell selectivity, antibiofilm anti-inflammatory activities, we newly analog, BP100-W, in which Leu-3 at hydrophobic face of was replaced by Trp. BP100-W possessed better 1.7-fold higher therapeutic index than BP100....
Leucine residues are commonly found in the hydrophobic face of antimicrobial peptides (AMPs) and crucial for membrane permeabilization, leading to cell death invading pathogens. Melittin, which contains four leucine residues, demonstrates broad-spectrum properties but also significant cytotoxicity against mammalian cells. To enhance selectivity melittin, this study synthesized five analogs by replacing with its structural isomer, 6-aminohexanoic acid. Among these analogs, Mel-LX3 exhibited...
We developed two short helical antimicrobial peptides, HVF18-a3 and its d-enantiomer, HVF18-a3-d, derived from the thrombin C-terminal peptide HVF18. These peptides exhibit potent activity against various bacteria by compromising both outer inner membranes, with low hemolytic activity. They are stable in presence of physiological salts human serum, exhibiting a potential for developing drug resistance excellent antibiofilm Gram-negative bacteria. HVF18-a3-d also neutralized...
BMAP-18, derived from the N-terminal region of bovine myeloid antimicrobial peptide BMAP-27, demonstrated potent activity without cytotoxicity. This study aimed to compare antibacterial, antibiofilm, and anti-inflammatory properties rich in aromatic phenylalanine residues, with its aliphatic analogue, BMAP-18-FL. Both BMAP-18 BMAP-18-FL exhibited equally activities against Gram-positive Gram-negative bacteria, particularly methicillin-resistant Staphylococcus aureus (MRSA)...
Prevalence of iron deficiency anemia is more common among adolescent girls. A descriptive study to assessthe knowledge, practice and attitude on girls was conducted. Thestudy objectives were assess the level anemiaamong girls, find out association between attitudeon with their selected demographic variables, findout correlation knowledge & practice, attitude. 100Adolescent in age group 13-18 years as a sample for this study, based inclusioncriteria. The purposive sampling technique used....
One of the most important indicators a nation’s progress and prosperity is its health. Ensuring healthy lives promoting well-being at all ages essential to sustainable development. The role healthcare professionals in enhancing hospital’s reputation providing excellent patient care critical. This article deliberates re-evaluation health services presents structured study on reallocation various patients Nigeria. study’s hypotheses objectives were substantiated terms effectiveness...