A5047167049- Renal Diseases and Glomerulopathies
- Extracellular vesicles in disease
- Chronic Kidney Disease and Diabetes
- MicroRNA in disease regulation
- Ion Transport and Channel Regulation
- Gut microbiota and health
- Clinical practice guidelines implementation
- Dialysis and Renal Disease Management
- Systemic Lupus Erythematosus Research
- Retinal Imaging and Analysis
- Intergenerational Family Dynamics and Caregiving
- Glycosylation and Glycoproteins Research
- Renal and Vascular Pathologies
- Global Health Care Issues
- Fiscal Policy and Economic Growth
- Local Government Finance and Decentralization
- Cardiovascular Disease and Adiposity
- Clostridium difficile and Clostridium perfringens research
- Inflammasome and immune disorders
- Medical Coding and Health Information
- Diet and metabolism studies
- Neutropenia and Cancer Infections
- Celiac Disease Research and Management
- Environmental Quality and Pollution
- Cholesterol and Lipid Metabolism
The First People's Hospital of Xiaoshan District, Hangzhou
2024
VA NY Harbor Healthcare System
2021
Zhongda Hospital Southeast University
2017-2020
People's Hospital of Xinjiang Uygur Autonomous Region
2012-2020
Southeast University
2018
Weatherford College
2013
Nagoya University
2010-2013
Nankai University
2004-2013
Xiamen University
2013
Shandong University of Traditional Chinese Medicine
2013
The suppression of tumorigenicity 2/IL-33 (ST2/IL-33) pathway has been implicated in several immune and inflammatory diseases. ST2 is produced as 2 isoforms. membrane-bound isoform (ST2L) induces an response when bound to its ligand, IL-33. other a soluble protein (sST2) that thought be decoy receptor for IL-33 signaling. Elevated sST2 levels serum are associated with increased risk cardiovascular disease. We investigated the determinants plasma concentrations 2,991 Framingham Offspring...
Background Glomerular endothelium dysfunction, which plays a crucial role in the pathogenesis of early diabetic nephropathy, might be caused by circulating metabolic abnormalities. Platelet microparticles, extracellular vesicles released from activated platelets, have recently emerged as novel regulator vascular dysfunction. Methods We studied effects platelet microparticles on glomerular endothelial injury nephropathy rats with streptozotocin-induced diabetes and primary rat cells. Isolated...
Background: Our previous study demonstrated that the disruption of cholesterol homeostasis promotes tubulointerstitial injury in diabetic nephropathy (DN).This aimed to further investigate effects gut microbiota dysbiosis on this process and explored its potential mechanism.Methods: Diabetic rats treated with broad-spectrum oral antibiotics or faecal transplantation (FMT) from healthy donor group human kidney 2 (HK-2) cells stimulated sodium acetate were used observe homeostasis.The...
Background With the gradual aging of population, geriatric depression has become a major public health issue in China owing to its overall upward trend and associated negative socio-economic impact. Dearth information regarding burden correlates among Uyghur minority population Xinjiang Autonomous Region, called for comprehensive survey involving representative sample designing efficient targeted intervention control this disabling disease. Methods A cross-sectional study was conducted 1329...
New non-invasive biomarkers are demanded to identify renal damage in various autoimmune-associated kidney diseases. Glomerular podocyte mediated by systemic lupus erythematosus (SLE) plays an important role the pathogenesis and progression of nephritis (LN). This study evaluated whether podocyte-derived microparticles (MPs) were novel clinical histological features SLE patients with LN. A cross-sectional study, including 34 16 healthy controls, was designed. Urinary annexin V+ podocalyxin+...
Renal interstitial fibrosis (RIF) is a common feature that facilitates the progression of chronic kidney disease (CKD), and emerging lines evidence suggest microRNA-376b (miR-376b) capable promoting RIF. In this study, we examined collagen deposition in tissues, autophagy mitochondrial reactive oxygen species (ROS) macrophages, apoptosis fibroblasts (KFBs) after promotion or suppression endogenous miR-376b cultured macrophages renal obtained from mice with CKD.FVB/N were prepared to...
IgA nephropathy (IgAN) is one of the most common forms idiopathic glomerular diseases and might lead to end-stage kidney disease. Accurate non-invasive biomarkers for early diagnosis are required intervention consequent therapy IgAN patients. Because variance in disease incidence predisposing genes has been detected among different ethnicities, ethnicity factor should be considered biomarker discovery. The differences protein profiles pathological mechanisms patients Uygur need clearly...
Increased plasma level of lipoprotein(a) (Lpa) is a risk factor cardiovascular diseases. This study aimed to explore the role Lpa in progression atherosclerosis patients with end-stage renal disease (ESRD) and investigate whether its potential mechanism mediated by CXC chemokine ligand 16 (CXCL16) low-density lipoprotein receptor (LDLr). retrospective clinical study. From January 2015 April 2016, forty-six ESRD from Danyang First People's Hospital were investigated. The grouped according...
Abstract Background Chronic kidney disease (CKD) is a common comorbidity of chronic obstructive pulmonary (COPD). Although high hemoglobin (Hb) detrimental to CKD patients, its relationship with poor outcomes in the COPD population has not been reported. This study aimed investigate between Hb and in-hospital mortality explore reference intervals patients CKD. Methods retrospective was multicenter population-based. A total 47,209 who presented January 2012 December 2016 were included. The...
Idiopathic membranous nephropathy (IMN) is an immune-mediated inflammatory disease characterized by a high risk of thromboembolic complications. Microparticles (MPs), type extracellular vesicles, have procoagulant properties, especially when they display tissue factor (TF). This study aimed to investigate whether circulating TF-positive MPs contributed the hypercoagulable state in patients with IMN.Twenty adult IMN and fourteen healthy subjects were included study. The basic indexes routine...
We compare growth rates in the absence and presence of life insurance using an overlapping generations framework with human capital accumulation to clarify how contributes economic through education investment individuals depending on circumstances. Our results show that, as expected, rate is higher when there if time preference or productivity sufficiently low income loss induced from lifetime uncertainty moderate. However, large, lower insurance.
Abstract Background The Charlson Comorbidity Index (CCI) can be automatically calculated from the International Classification of Disease (ICD) code. However, feasibility this transformation has not been acknowledged, particularly in hospitals without a qualified ICD coding system. Here, we investigated utility coding-based CCI China. Methods A multi-center, population-based, retrospective observational study was conducted, using dataset incorporating 2,464,395 adult subjects 15 hospitals....
Aortic prosthesis-patient mismatch (PPM) increases left ventricular (LV) afterload and prevents LV mass regression (LVMR) after surgery. This study was designed to investigate the association between baseline global longitudinal strain (GLS) postoperative LVMR, its relation adverse outcomes.A total of 316 patients with aortic stenosis undergoing isolated mechanical prosthesis implantation were screened, data from 91 PPM 165 non-PPM retrospectively collected. All 256 underwent measurement GLS...
During the COVID-19 pandemic, need for judicious use of diagnostic tests and to limit personnel exposure has led increased dependence on point-of-care ultrasound (POCUS) examinations. We reviewed POCUS findings in patients admitted intensive care unit (ICU) acute respiratory failure with correlated severity illness 30-day outcomes. Patients ICU March April 2020 were inclusion (acute hypoxemic secondary pneumonia; documentation findings). Forty-three met criteria. B lines pleural thickening...
To investigate the effects of epidermal growth factor receptor(EGFR) inhibitor Gefitinib on airway inflammation and remodelling in asthmatic C57BL/6 mice, to analyze its possible mechanisms.
The aim of the present study was to explore correlation between single nucleotide polymorphisms (SNPs) rs3840858 and rs2304921 in a specific α-2,6 sialyltransferase gene, ST6GALNAC2, susceptibility immunoglobulin (IgA) nephropathy (IgAN). distributions genotypes SNPs ST6GALNAC2 were detected by direct sequencing. genotype allele frequencies patients with IgAN significantly different from those control group (genotypes, P=0.001; alleles, P=0.001). DI ratio (17.8%) higher than that (5.6%) I...