A5101622197- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Histone Deacetylase Inhibitors Research
- Chronic Myeloid Leukemia Treatments
- CAR-T cell therapy research
- Digital Imaging for Blood Diseases
- Chronic Lymphocytic Leukemia Research
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Platelet Disorders and Treatments
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Radiopharmaceutical Chemistry and Applications
- Liver physiology and pathology
- RNA Research and Splicing
- T-cell and Retrovirus Studies
- Hematological disorders and diagnostics
- Lymphoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Hemophilia Treatment and Research
- Immune cells in cancer
- Viral Infectious Diseases and Gene Expression in Insects
- RNA Interference and Gene Delivery
Chongqing Medical University
2016-2025
Dalian Medical University
2016-2025
Second Affiliated Hospital of Chongqing Medical University
2016-2025
Chongqing University
2024
Creative Commons
2021
Weatherford College
2021
Damascus University
2019
Army Medical University
2016
Abstract N6-methyladenosine (m6A) is the most abundant posttranscriptional modification of mRNA in eukaryotes. Recent evidence suggests that dysregulated m6A-associated proteins and m6A modifications play a pivotal role initiation progression diseases such as cancer. Here, we identified IGF2BP3 specifically overexpressed acute myeloid leukemia (AML), subtype associated with poor prognosis high genetic risk. required for maintaining AML cell survival an m6A-dependent manner, knockdown...
Although mesenchymal stromal cells (MSCs) possess immunomodulatory properties and exhibit promising efficacy against chronic graft-versus-host disease (cGVHD), little is known about the of MSCs in prophylaxis cGVHD after HLA-haploidentical hematopoietic stem-cell transplantation (HLA-haplo HSCT).In this multicenter, double-blind, randomized controlled trial, we investigated incidence severity among patients, changes T, B, natural killer (NK) repeated infusion MSCs.The 2-year cumulative group...
Relapse is a major cause of treatment failure after allogeneic hematopoietic stem-cell transplantation (allo-HSCT) for high-risk acute myeloid leukemia (HR-AML). The aim this study was to explore the effect recombinant human granulocyte colony-stimulating factor (rhG-CSF) combined with minimal-dose decitabine (Dec) on prevention HR-AML relapse allo-HSCT.We conducted phase II, open-label, multicenter, randomized controlled trial. Two hundred four patients who had received allo-HSCT 60-100...
Hemophilia A (HA) is an X-linked recessive inherited bleeding disorder that typically affects men. Women are usually asymptomatic carriers, and rarely presenting with severe or moderately phenotype. This study aims to describe a case of 17-year-old girl moderate HA, investigating the mechanisms her condition genetic basis within family. We conducted coagulation tests assessments evaluate Molecular examinations, karyotype analysis, X-chromosome inactivation testing, targeted bioinformatic...
FMS-like tyrosine kinase 3 (FLT3) is the most frequently mutated gene in acute myeloid leukemia (AML), and associated with poor prognosis a high relapse rate. Gilteritinib, second-generation FLT3 inhibitor, an important target drug for treating patients FLT3-internal tandem duplication (ITD) AML, approved treatment of relapsed/refractory FLT3-mutant leukemia, although challenges such as resistance reduced potency remain. Herein, mitoxantrone-liposomes sensitized FLT3-ITD AML cells to...
Ginsenoside Rg3 is one of the main constituents isolated from Panax ginseng, and exhibits cytotoxic effects against cancer cells. The present study aimed to investigate ginsenoside on human multiple myeloma cells, determine underlying molecular mechanisms. cells were exposed at various concentrations (0‑80 µM) for 48 h. A subsequent cell proliferation assay demonstrated that treatment with resulted in a dose‑dependent inhibition U266 RPMI8226 Furthermore, exposure led marked increase rate...
Objective: Acute myeloid leukemia (AML) is a malignant clonal disorder. Despite enormous progress in its diagnosis and treatment, the mortality rate of AML remains high. The aim this study was to identify prognostic biomarkers by using gene expression profile dataset from public database, improve risk-stratification criteria survival for patients with AML. Materials methods: data clinical parameter were acquired Therapeutically Applicable Research Generate Effective Treatment (TARGET)...
Abstract Purpose The synergistic effects of combining arsenic compounds with imatinib against chronic myeloid leukemia (CML) have been established using in vitro data. We conducted a clinical trial to compare the efficacy realgar–indigo naturalis formula (RIF) plus that monotherapy patients newly diagnosed phase CML (CP-CML). Methods In this multicenter, randomized, double-blind, 3 trial, 191 outpatients CP-CML were randomly assigned receive oral RIF (n = 96) or placebo 95). primary end...
Alternative splicing (AS), a crucial post-transcriptional regulatory mechanism in expanding the coding capacities of genomes and increasing diversity proteins, still faces various challenges regulation acute myeloid leukemia (AML) microenvironmental changes.A total 27,833 AS events were detected 8337 genes 178 AML patients, with exon skip being predominant type. Approximately 11% significantly related to prognosis, prediction models based on demonstrated high classification efficiencies....
Aberrant lipid metabolism is a hallmark of malignant cancers. Recent studies have shown that abnormal activation the lipolysis pathway might contribute to acute myeloid leukemia (AML) progression. However, molecular mechanism through which mediates AML progression unknown. RNA-sequencing was used screen out target gene pnpla2/ATGL(adipose triglyceride lipase), showed differential expression in AML. A comparison made ATGL mRNA levels different cell lines by real-time PCR. blocked using...
The mobilization of hematopoietic stem cells (HSCs) using granulocyte colony-stimulating factor is a classic method. Recently, single injection pegfilgrastim was used to mobilize CD34+ in some small-sample studies. To confirm the efficacy and safety from healthy donors, we conducted retrospective multicenter study. A total 146 donors who all received subcutaneous (12 mg) on day 1 were enrolled our Donor HSC apheresis 5. primary endpoint percentage whom ≥4 × 106 cells/kg collected session....
Acute myeloid leukemia (AML) is a common hematological malignancy. Gemtuzumab ozogamicin (GO), humanized anti-CD33 antibody conjugated with the potent anti-tumor antibiotic calicheamicin, represents promising targeted therapy for AML. Annexin A5 (ANXA5) proposed marker clinical prognosis of AML to guide treatment choice.In total, 253 patients pediatric were enrolled and divided into two groups: conventional chemotherapy alone in combination GO. Univariate, multivariate, Kaplan-Meier survival...
Augmenter of liver regeneration (ALR) is a thermostable cytokine that was originally identified to promote the growth hepatocytes. This study conducted explore expression and function ALR in multiple myeloma (MM), common hematologic malignancy. Real-time PCR western blot analysis were performed detect U266 human MM cells healthy peripheral blood mononuclear (PBMCs). exposed 20 or 40 μg/mL recombinant tested for cell proliferation. Small interfering RNA-mediated silencing done investigate...
We present a 56-year-old woman with bilateral pleural effusions, widespread enlarged lymph nodes, and soft tissue masses located within the renal pelvis. The initially working diagnosis was tuberculosis lymphoma. Further pathological examination of node biopsy confirmed extramedullary hematopoiesis, bone marrow revealed myelofibrosis. Unlike common treatment options such as radiotherapy and/or surgery, intrathoracic cisplatin dexamethasone for effusions secondary to hematopoiesis...
Background: Primary immune thrombocytopenia (ITP) is an autoimmune disease and rituximab (RTX) induces the best long-term effect among second-line treatments. Zuberitamab innovative anti-CD20 monoclonal antibody, which was first developed in China launched diffuse large B lymphoma. This study aimed to investigate safety, efficacy, anticipated therapeutic dose of zuberitamab Chinese ITP patients. Methods: randomised, double-blind, placebo-controlled, phase 2 conducted at 26 hospitals China....
Abstract Background Chronic myeloid leukemia (CML) is a common hematological malignancy, and tyrosine kinase inhibitors (TKIs) represent the primary therapeutic approach for CML. Activation of metabolism signaling pathway has been connected with BCR::ABL1-independent TKIs resistance in CML cells. However, specific mechanism by which mediates this drug remains unclear. Here, we identified one relationship between glutamine synthetase (GS) Imatinib Methods GS PXN-AS1 bone marrow samples...
Background Chimeric antigen receptor T (CAR-T) cell therapy has been shown remarkable efficacy in the treatment of hematological malignancies recent years. However, a considerable proportion patients would experience tumor recurrence and deterioration. Insufficient CAR-T persistence is major reason for relapse. Multiple strategies to enhance long-term antitumor effects cells have explored developed. In this study, we focused on tyrosine kinase inhibitors (TKIs), which emerged...
Poor availability and a lack of affordability bypassing agents (recombinant activated factor VII prothrombin complex concentrate) in west China prompted us to investigate an alternative cost-effective combination therapy. We aimed explore the feasibility therapeutic plasma exchange (TPE)-based therapy treatment acquired hemophilia A (AHA).We retrospectively investigated clinical features AHA 6 patients who were treated with TPE, corticosteroids, rituximab our department for 9 years between...
Purpose: Acute myeloid leukaemia (AML) is a common haematological disease in adults. The overall survival (OS) remains unsatisfactory. It critical to identify potential prognostic biomarkers and develop nomogram that predicts patients with AML. Patients Methods: We used gene expression dataset clinical data from Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) differential analysis, value of IGHD family ( IGHDs ) AML patients. A risk score model was built through Lasso analysis...