A5061953889- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal and Macular Surgery
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Lipid metabolism and disorders
- Ocular Oncology and Treatments
- Epigenetics and DNA Methylation
- Ocular Diseases and Behçet’s Syndrome
- Retinal Development and Disorders
- Traumatic Ocular and Foreign Body Injuries
- Genetic Associations and Epidemiology
- Atherosclerosis and Cardiovascular Diseases
- Liver Disease Diagnosis and Treatment
- Corneal surgery and disorders
- interferon and immune responses
- MicroRNA in disease regulation
- Ophthalmology and Visual Impairment Studies
- Retinoids in leukemia and cellular processes
- Vascular Malformations Diagnosis and Treatment
- Ocular Infections and Treatments
- Curcumin's Biomedical Applications
- Fibroblast Growth Factor Research
- Systemic Lupus Erythematosus Research
Wenzhou Medical University
2021-2025
Affiliated Eye Hospital of Wenzhou Medical College
2021-2025
Ningbo University
2024
Anyang Eye Hospital
2016-2023
Go Sheng
2022
World Wide Web Consortium
2022
Central South University
2015-2020
Second Affiliated Hospital of Soochow University
2016-2019
Soochow University
2016-2019
Washington State University
1993
Background Optical coherence tomography angiography (OCTA) enables fast and non-invasive high-resolution imaging of retinal microvasculature is suggested as a potential tool in the early detection microvascular changes Alzheimer’s Disease (AD). We developed standardised OCTA analysis framework compared their extracted parameters among controls AD/mild cognitive impairment (MCI) cross-section study. Methods defined geometrical at different layers foveal avascular zone (FAZ) from segmented...
Little is known about whether sugar intake a risk factor for myopia, and the influence of glycemic control remains unclear, with inconsistent results reported. This study aimed to clarify this uncertainty by evaluating link between multiple traits myopia.We employed two-sample Mendelian randomization (MR) design using summary statistics from independent genome-wide association studies. A total six traits, including adiponectin, body mass index, fasting blood glucose, insulin, hemoglobin A1c...
Background Wet age-related macular degeneration (wAMD) is a vision-threatening eye disease worldwide. The amplitude of low-frequency fluctuation (ALFF) method was used to observe changes in spontaneous brain activity, which may help investigate the underlying pathological mechanism AMD. Methods Eighteen patients with wAMD and 18 age- gender-matched healthy controls (HCs) were recruited. ALFF on each subject mean values compared between groups. receiver operating characteristic (ROC) curve...
Introduction Optical Coherence Tomography Angiography (OCTA) is a cutting-edge imaging technique that captures retinal capillaries at micrometer resolution using optical instrument. Accurate segmentation of vasculature essential for eye related diseases measurement and diagnosis. However, noise artifacts from different instruments can interfere with segmentation, most existing deep learning models struggle segmenting small vessels capturing low-dimensional structural information. These...
A 53-year-old man with rheumatoid arthritis was first diagnosed scleromalacia at the ophthalmology clinic after experiencing ocular trauma. The patient presented decreased vision and abnormalities were subsequently found in his other eye. An ophthalmologist performed emergency debridement suturing surgery on ruptured right eyeball, discovering that sclera thinned to only 1/5 1/3 of its normal thickness. After operation, examined patient’s eye noted similar bluish scleral changes along...
Diabetic retinopathy (DR) is a major cause of vision loss worldwide. Here, we perform single-cell RNA sequencing thirteen human retina samples (from living and post-mortem donors) across non-diabetic, diabetic, DR states to create comprehensive transcriptomic atlas. We uncover three distinct microglial states: homeostatic, stress-response, inflammatory, along functional continuum, rather than discrete activation states, with dynamic transitions occurring throughout disease progression....
This case report discusses the appearance of beaded bubbles after C3F8 gas fill in a patient who underwent vitrectomy for proliferative diabetic retinopathy.
The human retina exhibits complex cellular heterogeneity which is critical for visual function, yet comprehensive ethnic-specific references are scarce in ophthalmic transcriptomics. lack of single-cell RNA sequencing (scRNA-seq) data from Asian populations particularly Chinese donors imposes significant limitations understanding population-specific retinal biology. We constructed the first transcriptomic atlas donors, generated through high-throughput scRNA-seq ~290,000 viable cells...
Early computer-aided early diagnosis (CAD) based on retinal imaging is critical to the timely management and treatment planning of retina-related diseases. However, inherent characteristics images complexity their pathological patterns, such as low image contrast different lesion sizes, restrict performance CAD systems. Recently, ultra-wide-field (UWF) have become a useful tool for disease detection due capability capturing much broader view retina (i.e., up 200°), in comparison with most...
Metastasis is a major cause of death in UM, highlighting the need to use highly specific and sensitive prognostic markers identify patients with risk developing metastasis.
Abstract Purpose To characterize profile of cytokines in aqueous humour common macular diseases during intravitreal anti‐ VEGF therapy. Methods Aqueous from eyes with central retinal vein occlusion ( CRVO ), branch BRVO diabetic oedema DME neovascular age‐related degeneration nAMD ) or pathologic myopia associated choroidal neovascularization (pm CNV was sampled prior to 1st n = 144) and 2nd 48) Cytokines including vascular endothelium growth factor intercellular adhesion molecule 1 ICAM ‐1)...
Age-related macular degeneration (AMD) is one of the major causes vision loss. Early AMD needs to be taken seriously, but causal effects lipid biomarkers on early remain unclear. In this study, two-sample Mendelian randomization (MR) analysis was performed systematically assess relationships between seven serum (apolipoprotein A (ApoA), apolipoprotein B (ApoB), total cholesterol (CHOL), high-density lipoprotein (HDL-C), direct low-density (LDL-C), [Lp(a)], and triglycerides (TG)) risk AMD....
Aims Observational studies have shown that sleep pattern is associated with age-related macular degeneration (AMD), but whether a causal factor for AMD remains unclear. This study aims to use Mendelian randomization (MR) analysis investigate the potential relationship between traits and AMD. Methods two-sample MR study. The single-nucleotide polymorphisms early were selected as outcome from two different genome-wide association (GWAS): GWAS 14,034 cases 91,214 controls, 3,553 147,089...
Retinoblastoma is an severe ophthalmic disease and the most common type intraocular malignant tumor, particularly in infants. Currently, few drugs therapies are available. Gene therapy has been considered to be a potential treatment cure cancer effectively Herpes simplex virus 1 thymidine kinase/ganciclovir (HSV‑TK/GCV) one of suicide gene that extensively studied. Numerous vitro vivo studied have shown this system can kill tumor cells, including liver lung cells. GCV used as antiviral drug,...
Uveal melanoma (UM) represents the most common primary intraocular malignancy in adults and is characterized by aggressive behaviors a lack of targeted therapies. Hypoxia-targeted therapy has become promising new therapeutic strategy tumors. Therefore, better understanding tumor hypoxia microenvironment critical to improve treatment efficacy UM. In this study, we conducted an extensive multi-omics analysis explore heterogeneity prognostic significance microenvironment. We found that UM...
2-Ethylhexyl diphenyl phosphate (EHDPP) is a frequently utilized organophosphorus flame retardant (OPFR) and has been extensively detected in environmental media. Prolonged daily exposure to EHDPP linked potential retinal damage, yet the adverse impacts on retina are still generally underexplored. In this research, we explored oxidative stress, inflammation, activating mechanisms initiated by mouse photoreceptor (661 W) cells following 24 h period. Our research demonstrated that led decline...
Fast and automated reconstruction of retinal hyperreflective foci (HRF) is great importance for many eye-related disease understanding. In this paper, we introduced a new framework, driven by recent advances in deep learning to automatically extract 12 three-dimensional parameters from the segmented optical coherence tomography (OCT).Unlike traditional convolutional neural networks, which struggle with long-range feature correlations, introduce spatial channel attention module within...
According to the latest data from Bureau of Disease Control and Prevention National Health Family Planning Commission, China currently has 199.6 million diabetic patients become world's largest country with diabetes. The prevalence rate is as high 14.3%, which much higher than world average 5.8%. primary-level ophthalmic screening service one important tasks improve medical services, corresponding imaging diagnosis technology an support for health services. Therefore, it very necessary us...