A5023256445- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cell death mechanisms and regulation
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- TGF-β signaling in diseases
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Protein Degradation and Inhibitors
- Cancer-related gene regulation
- Multiple Myeloma Research and Treatments
- Renal and related cancers
- RNA and protein synthesis mechanisms
- Parasites and Host Interactions
- Natural Compounds in Disease Treatment
- Radiation Therapy and Dosimetry
- Phagocytosis and Immune Regulation
- Genetic factors in colorectal cancer
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Plant Disease Resistance and Genetics
Fujian Medical University
2025
Guangxi Medical University
2024
Peking University Third Hospital
2024
Peking University
2018-2024
Weifang Medical University
2022
Qingdao University
2020-2021
Qingdao Municipal Hospital
2020-2021
Second Affiliated Hospital of Xinjiang Medical University
2021
Xinjiang Medical University
2021
Southern Medical University
2021
bcl-2 and bax belong to the bcl-2-related gene family, which marks a new class of genes that influence apoptosis. The oncogene acts as broad antiapoptotic factor extends both normal tumour cell survival. In contrast, is promoter apoptosis.To analyse expression in pancreatic cancer correlate results with clinical parameters.Pancreatic tissue samples were obtained from 28 female 32 male patients (median age 63, range 43-79 years) having surgery for cancer. Normal tissues 18 previously healthy...
Objective To analyze the expression of antiapoptotic gene bcl-xL in human pancreatic cancer and to correlate results with clinical patient parameters. Summary Background Data Bcl-xL belongs bcl-2-related family acts as a broad factor extend both normal tumor cell survival. Recent findings indicate that death induced by chemotherapy radiotherapy is mediated activation apoptosis. The fact has an extremely malignant potential it resistant most anticancer treatment modalities suggests mechanisms...
Abstract Although immune checkpoint inhibition in particular has shown promise cancer immunotherapy, it is not always efficient. Recent studies suggest that SMARCAL1 may play a role tumor evasion, yet its pan-cancer unclear. We conducted comprehensive analysis of using TCGA, GTEx, and CCLE databases, evaluating expression, genetic alterations, epigenetic modifications, their clinical correlations across 33 types. Our findings indicate overexpressed several cancers, such as Glioma, LUAD,...
Objectives To determine which mechanisms are involved in pancreatic remodeling, repair, and fibrosis after acute necrotizing pancreatitis (NP) humans. Summary Background Data Transforming growth factor betas (TGF-βs) multifunctional polypeptides that have been implicated the regulation formation of extracellular matrix fibrosis. They exert their functions by binding to specific receptors. In this study, we analyze expression TGF-β1, TGF-β2, TGF-β3 receptors type I (Tβ-RI [ALK5]), II...
Multidrug-resistance 1 (MDR1) encodes a 170-kDa transmembrane glycoprotein (P-glycoprotein), which acts as drug-efflux pump. In the present study, we analyzed expression of MDR1/P-glycoprotein in human pancreatic cancer and correlated results with clinical parameters. Pancreatic tissue samples were obtained from 67 patients (30 female, 37 male) who underwent surgery. Normal tissues 15 previously healthy organ donors (4 11 served controls. MDR1 mRNA levels by Northern blotting, exact site was...
Abstract Cisplatin is still one of the first-line drugs for chemotherapy head and neck squamous cell carcinoma (HNSCC) shows a survival advantage HNSCC. However, substantial proportion HNSCC eventually becomes resistance to cisplatin underlying mechanisms remain be fully understood. Yin Yang 1 (YY1) multifunctional protein regulating both gene transcription modifications also plays role in resistance. Here, we reported that knockdown YY1 by lentivirus-mediated short hairpin RNA or...
The programmed cell death-ligand-1 (PD-L1) and bromodomain protein 4 (BRD4) are frequently overexpressed in cancer have even been shown to act synergistically. aim of this study was determine their potential oncogenic role .in tongue squamous carcinoma (TSCC). We detected significantly higher expression levels both PD-L1 BRD4 TSCC tissues compared normal (P ≤ .05). In addition, the high were associated with increased tumor lymphatic metastasis .05), staging .01), as well Genetic...
The DNA-binding protein RFX6 was overexpressed in hepatocellular carcinoma, and its expression level correlated with the prognosis immune cell infiltration liver carcinoma. However, mechanism of abnormal biological effects cancer remains unknown.To understand specific cancer, we performed bioinformatic prediction, CHIP-qPCR assay, co-IP, dual-luciferase assay to assess regulating RFX6. In meantime, a series experiments vivo vitro were conducted analyze significance carcinoma.We demonstrated...
Number 3 Prescription (WD-3) is an herbal remedy used in traditional Chinese medicine that has been shown to improve the outcomes of patients with advanced colon and gastric cancers. This study aimed investigate effect WD-3 on proliferation, glycolysis, hexokinase 2 expression breast cancer cells. Four cell lines (MDA-MB-231, BT-549, MCF-7, MCF-7/ADR-RES) were treated different concentrations compared blank control (phosphate-buffered saline). Each was also divided into WD-3, paclitaxel,...
BACKGROUND: Pyruvate kinase M2 (PKM2) is highly expressed in multiple cancer types and contributes to the Warburg effect. METHODS: We have used various approaches including animal studies, human GBM specimen analyses, biochemical understand cellular functions of PKM2. RESULTS: uncovered mechanisms underlying upregulation PKM2, nuclear translocation metabolic non-metabolic PKM2 promoting cell metabolism, proliferation, cycle progression. CONCLUSIONS: concluded that function essential for...
Abstract Background: Cancer stem cells (CSCs), which are characterized by self-renewal and plasticity, highly correlated with tumor metastasis drug resistance. To fully understand the role of CSCs in colorectal cancer (CRC), we evaluated stemness traits prognostic value stemness-related genes CRC. Methods: In this study, data from 616 CRC patients The Genome Atlas (TCGA) were assessed subtyped based on mRNA expression-based index (mRNAsi). correlations immune microenvironment, mutational...