A5089298948- Venous Thromboembolism Diagnosis and Management
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Pancreatic and Hepatic Oncology Research
- Peripheral Artery Disease Management
- Vascular Procedures and Complications
- Intestinal Malrotation and Obstruction Disorders
- Glioma Diagnosis and Treatment
- Virology and Viral Diseases
- Bone health and osteoporosis research
- Esophageal and GI Pathology
- Renal and Vascular Pathologies
- Hepatocellular Carcinoma Treatment and Prognosis
- Blood properties and coagulation
- Gastrointestinal disorders and treatments
- Bacterial Infections and Vaccines
- Neuroendocrine Tumor Research Advances
- Vitamin D Research Studies
- Erythrocyte Function and Pathophysiology
- Pancreatitis Pathology and Treatment
- Intestinal and Peritoneal Adhesions
- Abdominal vascular conditions and treatments
- Platelet Disorders and Treatments
University of Debrecen
2014-2024
University of Pecs
1984-2024
European Society for Medical Oncology
2024
HUN-REN Institute of Earth Physics and Space Science
2023
Mikroelektronika (Czechia)
2023
Universidad Politécnica de Cartagena
2023
Hungarian Meteorological Service
2023
Eötvös Loránd University
2023
McMaster University
2018
University of Kapsovar
2010
Objective: This study was to investigate the outcome of status epilepticus (SE) associated with antiepileptic therapy during SE and in follow-up period, risk factors including age, co-morbidities, pre-existing epilepsy, aetiology East-Hungarian region. Methods: A prospective cross-sectional database compiled from outpatient files between 2013 2017. Follow-up ended on 30.06.2018. Results 135 episodes (male: 68, 50.4%) were evaluated, mean age time being 64.1±13.9 years 39.9±14.2 months,...
Abstract Background and Objectives Adhesion molecules are cell surface glycoproteins that important in cell‐to‐cell cell‐to‐extracellular matrix interactions. In the present study, we analyzed adhesion ICAM‐1 (intercellular molecule‐1), VCAM‐1 (vascular ELAM‐1 (endothelial leukocyte molecule‐1) human pancreatic cancer. Methods ICAM‐1, VCAM‐1, were 20 cancer specimens normal tissues. mRNA expression encoding was assessed with Northern blot analysis. The distribution localization of determined...
While medicine shortages are complex, their mitigation is more of a challenge. Prospective risk assessment as means to mitigate possible shortages, has yet be applied equally across healthcare settings. The aims this study have been to: 1) gain insight into risk-prevention against among experts; 2) review existing strategies for minimizing patient-health risks through assessment; and 3) learn from experiences related application in practice.A semi-structured questionnaire focusing on was...
Objectives To determine which mechanisms are involved in pancreatic remodeling, repair, and fibrosis after acute necrotizing pancreatitis (NP) humans. Summary Background Data Transforming growth factor betas (TGF-βs) multifunctional polypeptides that have been implicated the regulation formation of extracellular matrix fibrosis. They exert their functions by binding to specific receptors. In this study, we analyze expression TGF-β1, TGF-β2, TGF-β3 receptors type I (Tβ-RI [ALK5]), II...
In situ gels have been developed as an innovative strategy to prolong corneal residence time and enhance drug absorption compared traditional eye drops. Our study aimed formulate ophthalmic in gel with a combination of two thermosensitive poloxamers, P407 P188, optimal ratio not only increase the action but also solubility selected antibiotics for treatment infections. Two BSC II class substances, Azithromycin Ofloxacin, different mechanisms action, incorporated into system after determining...
Plasma and blood osmolality values show interspecies differences are strictly regulated. The effect of these factors also has an influence on microrheological parameters, such as red cell (RBC) deformability aggregation. However, little is known about the in RBC at various levels (osmotic gradient deformability). Our aim was to conduct a descriptive–comparative study osmotic several vertebrate species human blood. Blood samples were taken from healthy volunteers, dogs, cats, pigs, sheep,...
Introduction Acute ischemic stroke (AIS) is a potentially devastating disease with high disability and mortality. Recombinant tissue plasminogen activator (rt-PA) an effective treatment 2–8% possible risk for symptomatic intracranial hemorrhage (sICH). Our aim was to investigate the factors long-term clinical outcomes of ICH in patients after rt-PA treatment. Methods Consecutive AIS, thrombolysed at Department Neurology, University Debrecen, between 1 January 2004 31 August 2016 were...
IntroductionScarcity of age appropriate formulations for orally administered medicines paediatric malignancies is a critical and ongoing issue which necessitates urgent solutions. According to JARC Survey 27% oral were never available in child-friendly [2]. Pharmacists from the European Society Oncology Pharmacy Global (ESOP) Pediatric (SIOPE) have collaborated provide document summarising literature data on this topic set practical instructions preparation extemporaneous liquid...
Dosage forms with increased gastric residence time are promising tools to increase bioavailability of drugs narrow absorption window. Low-density floating formulations could avoid emptying; therefore, sustained drug release can be achieved. Our aim was develop a new technology produce low-density by melt foaming. Excipients were selected carefully, the criteria low irritation, melting range below 70°C and well-known use in oral formulations. PEG 4000, Labrasol stearic acid type 50 used...
Abstract The development of γ‐aminobutyric acid (GABA)‐immunoreactive neurons was investigated in the embryonic and posthatch chick lumbosacral spinal cord by using pre‐ postembedding immunostaining with an anti‐GABA antiserum. first GABA‐immunoreactive cells were detected ventral one‐half dorsal to lateral motor exception column, appeared throughout entire extent gray matter E6. Thereafter, extended from regions. Stained perikarya at E8 then progressively accumulated horn, while...
The effects of temperature on micro-rheological variables have not been completely revealed yet.To investigate heat treatment in human, rat, dog, and porcine blood samples.Red cell (RBC) - buffer suspensions were prepared immersed a 37, 40, 43°C heat-controlled water bath for 10 minutes. Deformability, as well mechanical stability RBCs measured ektacytometer. These tests also examined whole samples at various temperatures, gradually between 37 45°C the ektacytometer.RBC deformability...
Two Balb/C mouse models of Candida infection were used to detect serum interleukin-6 (IL-6) responses. The first model systemic by albicans ATCC 10231 strain infected through the lateral tail vein mice without any specific pretreatment. median burdens kidneys 1.5 × 106 CFU/ml 24 h postinoculation (p.i.) and 1.2 107 72 p.i., while IL-6 levels 479.3 pg/ml 934.5 pg/ml, respectively. burden showed significant correlation with p.i. (R 2 = 0.6358; P 0.0082) but not p.i.The second was a vaginitis...
Objectives: This retrospective single-center study aimed to investigate the risk factors, outcomes and complication rates in patients older vs. younger than 80 years treated with intravenous alteplase. Methods: Data of 1,253 thrombolysed were analyzed between January 1, 2004 August 31, 2016. Vascular stroke severity based on NIHSS score, functional outcome using modified Rankin Scale (mRS), mortality symptomatic intracerebral hemorrhage (SICH) compared two subgroups (<80 ≥80 years)....
Epilepsy is a widespread disease requiring long-term drug treatment. The aim of this study was to collect information on reported suspected adverse reactions (sADRs) antiseizure medications (ASMs) and their seriousness outcomes in various system organ classifications (SOCs). We intended compare old new ASMs' ADRs.
Cerebrovascular diseases are the leading cause of death and disability. The epidemiological background predisposing factors have been basis many studies. We aimed to assess effect seasonal variability meteorological on stroke incidence in Hungary. National county-level secondary data were assessed for 2018–2019. identified with ICD codes I60, I61, I62 (hemorrhagic), I63, I65, I66 (ischemic). obtained from University Pécs Clinical Centre (number patients per day according sex disease subtype,...
At the Medical University of Pécs, Hungary, percutaneous transluminal angioplasty was performed on 252 lesions in 235 patients. Primary success rate 75%. Long femoral artery occlusions were recanalized with a 66% patency 10-20 cm long and 47% longer than 20 cm. These relatively high rates attributed to use SP 54, fibrinolytic agent. In group 52 patients treated 54 there only four reocclusions, two these occurring 12 months after when discontinued. It concluded that may be amenable provided...
Introduction: Vitamin D (vitD) deficiency may have importance in some diseases, but there is a lack of data our country to clarify the current situation. Our aim was examine basic characteristics patients’ vitD status, and ratio its relation certain assess seasonality trends, reveal indirect impact COVID-19 pandemic on 3 supplementation at patient population level. Methods: Anonymized 25(OH)D test results were obtained from clinical registry tertiary teaching hospital covering period between...
A gastric tumor was found in a 64-year-old woman who later developed flushing, tachycardia, headache, and lacrymation. The plasma pancreatic polypeptide (PP) level 700 times normal values, the majority of cells were immunoreactive to PP antiserum. Symptoms alleviated, levels fell after embolization hepatic artery for liver metastases. This is first reported case PP-producing endocrine tumor.