A5112520436- Advancements in Transdermal Drug Delivery
- Nanoparticle-Based Drug Delivery
- Ferroptosis and cancer prognosis
- Nanoplatforms for cancer theranostics
- Cancer, Lipids, and Metabolism
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Advanced Polymer Synthesis and Characterization
- Advanced Battery Materials and Technologies
- Photopolymerization techniques and applications
- Conducting polymers and applications
- RNA modifications and cancer
- 3D Printing in Biomedical Research
- AI in cancer detection
- Autophagy in Disease and Therapy
- Fuel Cells and Related Materials
- Luminescence and Fluorescent Materials
- Drug Transport and Resistance Mechanisms
- Lung Cancer Treatments and Mutations
- Curcumin's Biomedical Applications
- Polymer Surface Interaction Studies
- Wound Healing and Treatments
- Rheumatoid Arthritis Research and Therapies
- Additive Manufacturing and 3D Printing Technologies
- Immunotherapy and Immune Responses
Hubei Normal University
2023-2025
Guangdong Pharmaceutical University
2025
First Affiliated Hospital of Guangdong Pharmaceutical University
2025
Huzhou Central Hospital
2021-2024
Zhejiang University
2021-2024
Zhejiang Chinese Medical University
2024
Huzhou University
2019-2024
Wannan Medical College
2024
Shenyang Pharmaceutical University
2017-2022
Shanghai University of Traditional Chinese Medicine
2019-2022
Ferroptosis is an iron-dependent, oxidative cell death, and characterized by iron-dependent accumulation of reactive oxygen species (ROS) within the cell. It has been implicated in various human diseases, including cancer. Recently, ferroptosis as a non-apoptotic form death induced small molecules emerging specific cancer types, however, its relevance colorectal (CRC) unexplored remains unclear. Here, we showed that inducer RSL3 initiated ROS HCT116, LoVo HT29 CRC cells over 24 h time...
Abstract Ferroptosis, a novel form of programmed cell death, is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases, including cancer. Stimulating ferroptosis cancer cells may potential strategy for therapy. Therefore, ferroptosis-inducing drugs are attracting more attention treatment. Here, we showed that erianin, natural product isolated from Dendrobium chrysotoxum Lindl , exerted its anticancer activity inducing death inhibiting...
Background and Purpose: RAS mutations limit the effectiveness of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies in combination with chemotherapy for metastatic colorectal cancer (mCRC) patients. Therefore, new cell death forms have focused on identifying indirect targets to inhibit Ras-induced oncogenesis. Recently, emerging evidence has shown potential triggering ferroptosis therapy, particularly eradicating aggressive malignancies that are resistant traditional...
Curcumenol, an effective ingredient of Wenyujin, has been reported that exerted its antitumor potential in a few cancer types. However, the effect and molecular mechanism curcumenol lung are largely unknown. Here, we found induced cell death suppressed proliferation cells. Next, demonstrated ferroptosis was predominant method contributed to curcumenol-induced vitro vivo for first time. Subsequently, using RNA sequencing, long non-coding H19 (lncRNA H19) significantly downregulated cells...
We present detailed studies of the relationship between ionic conductivity and segmental relaxation in polymer electrolytes. The analysis shows that can be decoupled from dynamics strength decoupling correlates with fragility but not glass transition temperature. These results call for a revision current picture transport relate observed phenomenon to frustration packing rigid polymers, where loose local structure is also responsible increase their fragility.
The study aimed to assess the oxidative modification behavior of bovine myofibrillar proteins (MPs) cysteines (Cys) by hydroxyl radical (·OH) through construction an in vitr Fenton reaction system. ·OH generated induced large-scale Cys, and redox proteomics identified a total 1192 differential oxidation sites (Dos), 59 Dos were located MPs structure. Cys actin (17 Dos), myosin/myomesin (16 tenascin (12 Dos) sarcomere (10 structure showed active towards ·OH, especially with "-C-X-X-X-X-W-"...
Baicalin, as a natural active ingredient extracted and isolated from the traditional Chinese medicine Scutellaria baicalensis Georgi., has been potentially used in various areas for its antioxidative, antitumor, anti-inflammatory, anti-proliferative activities. Although several studies have reported antitumor effects of baicalin against cancer types, beneficial on lung not yet elucidated. Therefore, therapeutic molecular mechanisms cell lines H1299 H1650 were investigated. Here, results...
Abstract 5-Fluorouracil (5-FU) is known as a first-line chemotherapeutic agent against colorectal cancer (CRC), but drug resistance occurs frequently and significantly limits its clinical success. Our previous study showed that the protocadherin 17 ( PCDH17 ) gene was methylated functioned tumor suppressor in CRC. However, relationship between 5-FU CRC remains unclear. Here, we revealed more highly expressed 5-FU-sensitive tissues than 5-FU-resistant tissues, high expression of correlated...
<h3>Objective:</h3> This study aimed to develop a new polyethylene glycol (PEG)ylated β-elemene liposome (PEG-Lipo-β-E) and evaluate its characterization, pharmacokinetics, antitumor effects safety <i>in vitro</i> vivo</i>. <h3>Methods:</h3> The liposomes were prepared by ethanol injection high-pressure micro-jet homogenization. Characterization of the was conducted, drug content, entrapment efficiency (EE), release stability studied ultra-fast liquid chromatography (UFLC) surface method....
Transdermal delivery is one of important controlled drug release strategies for development. Cubic phases are the assemblies amphiphilic molecules in water with hydrophilic–hydrophobic interpenetrating network transdermal both hydrophilic and hydrophobic drugs. However, many details about drugs from cubic remain unclear. Here, metformin hydrochloride (Met) were prepared glyceryl monooleate (GMO), ethanol, water. The structure was identified polarizing light microscopy small-angle X-ray...
Objective: In this study, we aimed to develop an amino-terminal fragment (ATF) peptide-targeted liposome carrying β-elemene (ATF24-PEG-Lipo-β-E) for targeted delivery into urokinase plasminogen activator receptor-overexpressing bladder cancer cells combined with cisplatin (DDP) treatment. Methods: The liposomes were prepared by ethanol injection and high-pressure microjet homogenization. characterized, the drug content, entrapment efficiency, in vitro release studied. targeting efficiency...
Jojoba (Simmondsia chinensis (Link) C.K. Schneid) is a dioecious plant in desert and semi-desert areas, e.g., the Ismailia Desert Egypt. oil (JJBO) natural slight yellow with functions of skin barrier repairing wound healing, which dermally applied as traditional medication or cosmetic Middle East. The objective this study was to prepare JJBO dry nanoemulsion powders (JNDs) investigate their anti-acute lung injury effects. nanoemulsions (JNEs) were prepared then lyophilized JNDs properties...
Histopathological images and omics profiles play important roles in prognosis of cancer patients. Here, we extracted quantitative features from histopathological to predict molecular characteristics prognosis, integrated image with mutations, transcriptomics, proteomics data for prediction lung adenocarcinoma (LUAD). Patients obtained The Cancer Genome Atlas (TCGA) were divided into training set (n = 235) test 235). We developed machine learning models estimated their predictive performance...
We have developed a highly versatile universal approach to grow polymer brushes from variety of substrates with high grafting density by using single-component system. describe random copolymer which consists an inimer, p-(2-bromoisobutyloylmethyl)styrene (BiBMS), copolymerized glycidyl methacrylate (GMA) synthesized reversible addition-fragmentation chain-transfer (RAFT) polymerization. Thermal cross-linking created mat that was stable during long exposure in organic solvent even sonication...