A5100666489- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Gut microbiota and health
- Kruppel-like factors research
- Inflammatory Bowel Disease
- Animal Nutrition and Physiology
- Cancer-related gene regulation
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Muscle Physiology and Disorders
- Aquaculture disease management and microbiota
- Metabolomics and Mass Spectrometry Studies
- Inflammasome and immune disorders
- Chromatography in Natural Products
- Bone Metabolism and Diseases
- Liver Disease Diagnosis and Treatment
- Oral and gingival health research
- Dental Research and COVID-19
- Cancer Genomics and Diagnostics
- Biofuel production and bioconversion
- Pancreatitis Pathology and Treatment
- Food composition and properties
- Dental materials and restorations
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
Wuhan University
2022-2025
General Hospital of Shenyang Military Region
2024-2025
Hangzhou Normal University
2018-2025
Huazhong University of Science and Technology
2021-2024
Tongji Hospital
2022-2024
ZheJiang Academy of Agricultural Sciences
2024
Shanxi University
2024
Sun Yat-sen University
2022-2024
The First Affiliated Hospital, Sun Yat-sen University
2022-2024
Peking University People's Hospital
2024
Curcumenol, an effective ingredient of Wenyujin, has been reported that exerted its antitumor potential in a few cancer types. However, the effect and molecular mechanism curcumenol lung are largely unknown. Here, we found induced cell death suppressed proliferation cells. Next, demonstrated ferroptosis was predominant method contributed to curcumenol-induced vitro vivo for first time. Subsequently, using RNA sequencing, long non-coding H19 (lncRNA H19) significantly downregulated cells...
Nearly half of all Asian non-small cell lung cancer (NSCLC) patients harbour epidermal growth factor receptor (EGFR) mutations, and first-generation EGFR tyrosine kinase inhibitors (TKIs) are one the first-line treatments that have improved outcomes these patients. Unfortunately, 20% can not benefit from treatment. The basis this primary resistance is poorly understood. Therefore, overcoming EGFR-TKI maintaining efficacy TKIs has become a key issue. β-Elemene, sesquiterpene compound...
Abstract This study aims to investigate the effects of commercial probiotic supplementation in water on performance parameters, carcass traits, immune function, and antioxidant capacity broiler chicks. In experiment, 120 Arbor Acres (AA) broilers (60 male 60 female) were randomly allocated into four groups (G) – G1: basal diet G2, G3, G4: with 1% Lactobacillus casei , L. acidophilus Bifidobacterium water, lasting 42 days. The experimental results revealed that additives produced positive...
HIV-1 is a RNA virus that requires an intermediate DNA phase via reverse transcription (RT) step in order to establish productive infection the host cell. The nascent viral synthesized RT and preformed proteins are assembled into pre-integration complex (PIC) cell cytoplasm. To integrate genome, PIC must cross nuclear membrane through pore (NPC). RanBP2, also known as Nup358, major component of cytoplasmic filaments emanates from has been implicated various nucleo-cytoplasmic transport...
Dementia is a serious adverse event (AE) that requires attention in clinical practice. However, information on drug-induced dementia limited. The U.S. FDA Adverse Event Reporting System (FAERS) serves as an important resource for identifying real-world drug reactions and safety signals. This study aimed to use FAERS data identify drugs associated with increased risk. A secondary analysis of the database was conducted using disproportionality methods. We reviewed dementia-related reports from...
Abdominal aortic aneurysms (AAAs) are characterized by pathological remodeling of the wall. Although both increased Krüppel-like factor 5 (KLF5) expression and macrophage infiltration have been implicated in vascular remodeling, role KLF5 AAA formation remains unclear.To determine into AAAs.KLF5 was significantly human tissues 2 mouse models experimental AAA. Moreover, myeloid-specific Klf5 knockout mice (myeKlf5-/- mice), infiltration, medial smooth muscle cell loss, elastin degradation,...
Objective: Compound Kushen injection (CKI), one of the commonly used antitumor Chinese patent medicines, has been widely prescribed as adjunctive treatment to platinum-based chemotherapy (PBC) in patients with advanced non-small cell lung cancer (NSCLC). However, efficacy and safety this combination therapy for NSCLC remain controversial. The objective study is evaluate effects CKI combined PBC on stage III/IV cancer. Methods: A systematic review meta-analysis were performed following PRISMA...
The TMEM16A protein is an important component of Ca(2+)-dependent Cl(-) channels (CaCCs) in vascular smooth muscle cells. A recent study showed that inhibits angiotensin II-induced proliferation rat basilar However, whether and how involved remodeling characterized by cell remains largely unclear. In this study, luciferase reporter, Western blotting, qRT-PCR assays were performed. results suggested myocardin promotes expression forming a complex with serum response factor (SRF) on the...
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) significantly improve the outcome of non-small-cell lung cancer (NSCLC) patients with EGFR mutations, however, most TKI-treated will develop resistance to TKIs.β-elemene, extracted from Curcuma aromatica Salisb., has been widely used treat various malignant tumors, including TKI-resistant NSCLC, but, effects and molecular mechanisms remain unclear.In this study, NCI-H1975 cell line harboring double mutations...
Both Klf5 (Krüppel-like factor 5) and Runx2 are involved in phenotypic switching of VSMC (vascular smooth muscle cells). However, the potential link between mediating vascular calcification remains unclear. The aim present study was to elucidate actual relationship calcification. We found that high Pi (phosphate) increased expression Klf5, which is accompanied by loss SM α-actin SM22α (smooth 22 α), as well gain expression. Overexpression increased, while knockdown decreased, Further showed...
Transmural healing (TH) is a potential therapeutic goal of Crohn's disease (CD) and associated with better clinical outcomes. However, few studies have described early TH its predictors.We aimed to evaluate predictors using magnetic resonance enterography (MRE) in patients CD receiving ustekinumab (UST).This was retrospective observational study.Patients active treated UST their intestinal segments bowel wall thickness (BWT) ⩽ 3 mm at baseline were included. Clinical characteristics,...