A5086962960- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Bioactive Compounds and Antitumor Agents
- Diet, Metabolism, and Disease
- SARS-CoV-2 and COVID-19 Research
- Cancer-related molecular mechanisms research
- Cardiovascular Health and Risk Factors
- Curcumin's Biomedical Applications
- vaccines and immunoinformatics approaches
- Magnolia and Illicium research
- Liver Disease and Transplantation
- Adipokines, Inflammation, and Metabolic Diseases
- Coronary Artery Anomalies
- Immunotherapy and Immune Responses
- Antifungal resistance and susceptibility
- Genomics, phytochemicals, and oxidative stress
- Cryptography and Data Security
- Plant-based Medicinal Research
- Quantum Computing Algorithms and Architecture
- Metabolomics and Mass Spectrometry Studies
- Cancer-related gene regulation
- Nutrition, Health and Food Behavior
- Viral Infectious Diseases and Gene Expression in Insects
- Toxin Mechanisms and Immunotoxins
- Retinoids in leukemia and cellular processes
Macau University of Science and Technology
2021-2025
Hangzhou Normal University
2017-2025
Institute of Information Engineering
2024
Chinese Academy of Sciences
2024
Affiliated Hospital of Hangzhou Normal University
2019-2023
Guangdong University of Technology
2022
Chengdu University of Traditional Chinese Medicine
2020
Chengdu Science and Technology Bureau
2020
Creative Commons
2020
Weatherford College
2020
Curcumenol, an effective ingredient of Wenyujin, has been reported that exerted its antitumor potential in a few cancer types. However, the effect and molecular mechanism curcumenol lung are largely unknown. Here, we found induced cell death suppressed proliferation cells. Next, demonstrated ferroptosis was predominant method contributed to curcumenol-induced vitro vivo for first time. Subsequently, using RNA sequencing, long non-coding H19 (lncRNA H19) significantly downregulated cells...
Background Colorectal cancer (CRC) is one of the most common malignancies and its incidence mortality are increasing yearly. 5-Fluorouracil (5-FU) has long been used as a standard first-line treatment for CRC patients. Although 5-FU-based chemotherapy effective advanced CRC, consequent resistance remains key problem causes poor prognosis Thus, there an urgent need to identify new biomarkers predict response chemotherapy. Methods samples were retrieved from Gene Expression Omnibus (GEO) The...
Lung cancer is a leading cause of mortality worldwide, especially among Asian patients with non-small cell lung (NSCLC) who have epidermal growth factor receptor (EGFR) mutations. Initially, first-generation EGFR tyrosine kinase inhibitors (TKIs) are commonly administered as the primary treatment option; however, encountering resistance to these medications poses significant obstacle. Hence, it has become crucial address initial and ensure continued effectiveness. Recent research focused on...
Background: Nonalcoholic fatty liver disease (NAFLD) has been proven to be associated with an increased risk of cognitive impairment and dementia, this association is more significant in non-obese NAFLD populations, but its pathogenesis remains unclear. Our study aimed explore the abnormalities spontaneous brain activity patients by resting-state fMRI (RS-fMRI) their relationship function. Methods: 19 NAFLD, 25 obese patients, 20 healthy controls (HC) were enrolled. All subjects underwent...
Abstract Although the development of COVID-19 vaccines has been a remarkable success, heterogeneous individual antibody generation and decline over time are unknown still hard to predict. In this study, blood samples were collected from 163 participants who next received two doses an inactivated vaccine (CoronaVac®) at 28-day interval. Using TMT-based proteomics, we identified 1,715 serum 7,342 peripheral mononuclear cells (PBMCs) proteins. We proposed sets potential biomarkers (seven serum,...
Bladder cancer is a highly prevalent and lethal malignant tumor characterized by frequent mutations/deletions of lysine-specific demethylase 6A (KDM6A), which suggested to be key event in progression metastasis. Beta-elemene has been shown inhibit metastasis growth various tumors, but its effect on KDM6A-null bladder cells remains unknown. This study aimed investigate the potential molecular mechanism β-elemene inhibiting cancer. examined migration ability viability RT-4 (KDM6A wild-type)...
The optimal blood pressure (BP) range for patients with metabolic dysfunction-associated fatty liver disease (MAFLD) is currently unknown. This study aimed to explore the relationship between stratified BP levels and MAFLD progression. data of adults who underwent yearly health check-ups were screened establish both a cross-sectional 6-year longitudinal cohort individuals MAFLD. was classified into following categories optimal, normal, high-normal, hypertension. Liver fibrosis diagnosed...
Abstract Background: Clinical and basic research supports that blood glucose fluctuation is an important predictor of diabetic vascular disease etiology lower extremity atherosclerosis, which pathological basis for diseases. Previous Chinese National Natural Science Foundation trials (No. 81503566) have reported the traditional medicine Shenqi compound can reduce low-grade inflammation, protect vessels; however, there are no high-quality clinical evidences available to support same. This...
The pharmacological mechanism of curcumin against drug resistance in non-small cell lung cancer (NSCLC) remains unclear. This study aims to summarize the genes and pathways associated with action as an adjuvant therapy NSCLC using network pharmacology, drug-likeness, pharmacokinetics, functional enrichment, protein-protein interaction (PPI) analysis, molecular docking. Prognostic were identified from curcumin-NSCLC intersection gene set for following sensitivity analysis. Immunotherapy,...
Concanavalin A (ConA)-induced liver damage of mice is a well-established murine model mimicking the human autoimmune hepatitis (AIH). However, pathogenic genes injury remain to be revealed.Using time-series transcriptome, top dynamic were inferred from set segmented regression models, and cross-checked by weighted correlation network analysis (WGCNA). AIH models created ConA used verify in vivo effect these genes.We identified 115 genes, which most overlapped with hub determined WGCNA. The...
Background: Recent studies demonstrate that N6-methyladenosine (m6A) methylation plays a crucial role in colorectal cancer (CRC). Therefore, we conducted comprehensive analysis to assess the m6A modification patterns and identify m6A-modified genes patients with CRC recurrence. Methods: The were comprehensively evaluated by NMF algorithm based on levels of 27 regulators, tumor microenvironment (TME) cell-infiltrating characteristics these systematically assessed ssGSEA CIBERSORT algorithms....
Metabolic dysfunction-associated fatty liver disease (MAFLD) brings heavy clinical and economic burdens to society, while understandings on heterogeneities are limited.We conducted a serum metabolomics study reveal the metabolic develop diagnostic strategy for MAFLD using discovery set consisting of 122 biopsy-proven patients [lean (n = 12), overweight 20), obese 74), type 2 diabetes mellitus (T2DM, n 16)] 35 controls, validation containing 60 (20 lean, 20 T2DM) controls.Mitochondrial...
: the proto-oncogene
Abstract The development of quantum computation enables exponential time complexity problems on classical computers to be solved in polynomial computers. However, it also poses a threat the security cryptographic schemes based integer factorization and discrete logarithms. In response this challenge, communication environments have become focal point research. public-key cryptosystem QSCD ff problem stands as one influential realm cryptography, yet its feasibility remains unexplored current...
This study reports a rare case of an Aspergillus infection the thoracolumbar vertebral body in chronic hepatitis B-related hepatocellular carcinoma patient. We report patient who presented with 3-month history lumbago after liver transcatheter arterial chemoembolization, and was finally diagnosed pulmonary diagnostic antifungal treatment for 1 year. suggests that therapy is great significance patients clinically suspected infections when it difficult to obtain tissue specimens determined diagnosis.
Coronavirus disease 2019 (COVID-19) is a global pandemic caused by the severe acute respiratory syndrome coronavirus-2.COVID-19 highly pathogenic and infectious. COVID-19 epidemic still spreading all over world, there no sign of stopping at present. There specific cure for this disease, clinical management mainly depends on supportive treatment. Xiyanping widely used in treating China. However, evidence that effective safe COVID-19.
Abstract Although the development of COVID-19 vaccines has been a remarkable success, heterogeneous individual antibody generation and decline over time are unknown still hard to predict. In this study, blood samples were collected from 163 participants who next received two doses an inactivated vaccine (CoronaVac ® ) at 28-day interval. Using TMT-based proteomics, we identified 1715 serum 7342 peripheral mononuclear cells (PBMCs) proteins. We proposed sets potential biomarkers (seven serum,...
Objective: To explore the key techniques used for surveillance and disposal of infectious diseases, food poisoning hospital infection to improve ability on public health emergency. Methods: Framework was set up, based literature review expert group discussion. Delphi method technique order preference by similarity ideal solution comprehensive evaluation were ordering similarity, screen above said events. Results: be selecting designed, classification emergency events, processing cycle events...
Objective To compare the effects of health education on fat intake behavior and its psychology in students with different BMI, provide evidence for improving individual healthy education. Methods A experimental epidemiology was used, Twenty-nine secondary school classes were randomly selected by multi-stage cluster sampling from two cities Zhejiang province.Overweight or obesity group included all who judged overweight obesity, normal basic matched age, grade, sex stage...