Chunguang Xie

ORCID: 0000-0002-0423-5515
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Research Areas
  • COVID-19 Clinical Research Studies
  • Traditional Chinese Medicine Studies
  • Acupuncture Treatment Research Studies
  • Traditional Chinese Medicine Analysis
  • Diabetic Foot Ulcer Assessment and Management
  • Wound Healing and Treatments
  • Complementary and Alternative Medicine Studies
  • Diabetes Treatment and Management
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Adipokines, Inflammation, and Metabolic Diseases
  • COVID-19 and Mental Health
  • Diabetes Management and Research
  • Metabolism, Diabetes, and Cancer
  • Pressure Ulcer Prevention and Management
  • Pharmacological Effects of Natural Compounds
  • Ginseng Biological Effects and Applications
  • Acute Ischemic Stroke Management
  • Hyperglycemia and glycemic control in critically ill and hospitalized patients
  • Ferroptosis and cancer prognosis
  • Morinda citrifolia extract uses
  • Flavonoids in Medical Research
  • Curcumin's Biomedical Applications
  • Trace Elements in Health
  • Pain Mechanisms and Treatments
  • Long-Term Effects of COVID-19

Chengdu University of Traditional Chinese Medicine
2010-2024

National Natural Science Foundation of China
2019-2020

Creative Commons
2019-2020

Weatherford College
2019-2020

Chengdu Science and Technology Bureau
2020

World Health Organization - Pakistan
2020

Group for the Analysis of Development
2020

National Medical Products Administration
2019

Abstract Ferroptosis, an iron‐dependent cell death characterized by lethal lipid peroxidation, is involved in chronic obstructive pulmonary disease (COPD) pathogenesis. Therefore, ferroptosis inhibition represents attractive strategy for COPD therapy. Herein, we identified natural flavonoid scutellarein as a potent inhibitor the first time, and its underlying mechanisms of COPD. In vitro, anti‐ferroptotic activity was investigated through CCK8, real‐time quantitative polymerase chain...

10.1002/ptr.7928 article EN Phytotherapy Research 2023-06-24

Diabetic angiopathy (DA) is a diabetic vascular complication. Pyroptosis an inflammatory death that plays important role in the development of DA, but underlying mechanisms have not been fully elucidated. The GSE169332 dataset from Gene Expression Omnibus (GEO) was subjected to single-cell RNA sequencing (scRNA-seq) analysis, and data mice were bulk RNA-seq. pathway through which microenvironment participated DA explored by pseudotime analysis cell-cell communication. models constructed...

10.1186/s12872-025-04604-z article EN cc-by-nc-nd BMC Cardiovascular Disorders 2025-03-13

Diabetic peripheral neuropathy (DPN) is one of the most common causes disability in diabetic population, and its pathogenesis related to a variety factors. There currently no effective treatment for such chronic disease. Traditional Chinese medicine has long clinical history prevention diabetes complications, it also shows certain advantages DPN. Many studies have confirmed that Huangqi Guizhi Wuwu decoction (HGWD) can reduce symptoms improve neuronal function patients with So we intend...

10.1097/md.0000000000016696 article EN cc-by-nc Medicine 2019-08-01

Insulin resistance (IR) is a recognized contributor to stroke association, and the estimated glucose disposal rate (eGDR) dependable indicator of IR. However, specific connections between eGDR, prevalence, overall mortality have not been thoroughly investigated. This study aimed examine how eGDR correlates with death rate. The leveraged information from National Health Nutrition Examination Survey (NHANES) spanning 2007 2016. To unravel data, team utilized logistic regression, cox...

10.1186/s12944-024-02385-6 article EN cc-by-nc-nd Lipids in Health and Disease 2024-11-28

Novel coronavirus pneumonia (COVID-19) is a very serious and urgent infectious disease. With the development of global economy improvement living standard, incidence diabetes increasing year by year. And it more common in elderly. COVID-19 associated with much chronic disease, especially diabetes. At present, there no systematic review meta-analysis mortality based on large scale data between all over world.The databases PubMed, Cochrane Library, EMBASE, Wanfang Data, China National...

10.1097/md.0000000000020913 article EN cc-by-nc Medicine 2020-06-29

Abstract Background: Diabetic foot (DF) is among the most serious complications of type 2 diabetes. DF infection (DFI) a key factor in deterioration and development DF, so controlling plays an important role treatment disease. Traditional Chinese medicine bath has been widely used China as complementary alternative therapy to improve circulation control DF. However, existing evidence shows that its efficacy safety are still insufficient. We report study protocol about multicenter,...

10.1097/md.0000000000019841 article EN cc-by-nc Medicine 2020-04-01

Coronavirus disease 2019 (COVID-19) is one of the infectious diseases that have seriously threatened global public health since its outbreak in 2019. Due to complicated Pathogenesis, high infectivity and fatality rate COVID-19, there currently no effective treatment for such epidemic disease. Traditional Chinese medicine has a long clinical history prevention this kind acute Qingfei Paidu Decoction (QFPD) widely used treating COVID-19 China. However, still lack comprehensive systematic...

10.1097/md.0000000000022040 article EN cc-by-nc Medicine 2020-09-01

Background: Coronavirus disease 2019 (COVID-19) is a respiratory illness that can spread from person to person. The virus causes COVID-19 novel coronavirus was first identified during an investigation into outbreak in Wuhan, China. clinical spectrum of SARS-CoV-2 infection appears be wide, encompassing asymptomatic infection, mild upper tract illness, and severe viral pneumonia with failure even death, many patients being hospitalised pneumonia. In China East Asia, Chinese medicine has been...

10.1097/md.0000000000020660 article EN cc-by-nc Medicine 2020-06-19

Abstract Background: As one of the major chronic diseases that seriously threaten human health, type 2 diabetes mellitus (T2DM) has become a global public health problem. Blood glucose fluctuation is risk factor independent hyperglycemia. At present, measures to treat blood fluctuations in patients with T2DM are insufficient effectiveness and safety. Medical practice clinical studies have proved Chinese herbal medicine obvious advantages reducing fluctuations. In this systematic review, we...

10.1097/md.0000000000021904 article EN cc-by-nc Medicine 2020-08-19

The number of people with diabetes and pre-diabetes is growing exponentially. Human studies have shown that zinc supplementation beneficial for pre-diabetes. However, owing to the low quality, small sample size, methodological heterogeneity these studies, this conclusion not convincing. Consequently, in order determine whether effective safe pre-diabetic patients, it necessary conduct a meta-analysis high-quality clinical trials.We will retrieve MEDLINE (PubMed), EMBASE, Web Science,...

10.1097/md.0000000000016259 article EN cc-by-nc Medicine 2019-07-01

Diabetic macular edema is a further complication of diabetes. It an important type diabetic eye disease and the main cause blindness patients. Qiming granule Chinese patent medicine widely used in treatment edema. There are some reports about this for At present, there only 1 systematic review on qiming However, many defects article, so it necessary to re-summarize evaluate existing evidence.

10.1097/md.0000000000017496 article EN cc-by-nc Medicine 2019-10-01

Abstract Background: Acute diarrhea is the 2nd highest prevalence disease among children under 5 years of age. It can cause malnutrition and even death in children, especially developing country. Traditional Chinese medicine therapy has been applied already guidelines for clinical practice acute infectious China, but there no specific methods or recommendations due to lacking evidence. Zusanli acupoint injection as a form acupuncture therapy, which proved be effective randomised controlled...

10.1097/md.0000000000016949 article EN cc-by-nc Medicine 2019-08-01

Abstract Background: Diabetes mellitus (DM) is one of the main health problems that perplex people all over world. The prevalence DM still increasing in spite great efforts have been made to control recent years. Type 2 diabetes (T2DM) most common type diabetes, accounting for about 90% cases. Traditional Chinese medicine has used on treatment and diabetic complications China many Baihu Jia Renshen Decoction (BJRD) oldest classic prescriptions traditional applied field diabetes’ treatment....

10.1097/md.0000000000020210 article EN cc-by-nc Medicine 2020-05-01

Abstract Background: Since the outbreak of novel coronavirus in 2019, number new infections worldwide has been increasing, there is no effective treatment or vaccine. Novel infection closely related todiabetes, mortality diabetes with pneumonia significantly higher than that non diabetic pneumonia, Diabetic foot one common and serious complications diabetes, however, systematic study on adverse effects found at home abroad, this a problem can not be ignored. Methods: We will search each...

10.1097/md.0000000000022758 article EN cc-by-nc Medicine 2020-10-23

Abstract Background: Diabetes is a common chronic metabolic disease. COVID-19 large-scale infectious disease that broke out in 2019, and 212 countries have now been infected with this Some studies shown combined diabetes an independent risk factor for death or other adverse outcomes. There currently no specific effective drug treatment. More more people realized the low-cost CQ its derivative HCQ antiviral anti-inflammatory capabilities may play huge role fight against COVID-19. At same...

10.1097/md.0000000000022031 article EN cc-by-nc Medicine 2020-09-10

COVID-19 has become a global epidemic, causing huge loss of life and property. Diabetes will affect the prognosis patients in many ways. Both hyperglycemia hypoglycemia can oxidative stress lead to release inflammatory mediators, leading multiple organ damage chronic inflammation. Here, we want know whether or adversely with diabetes comorbidities. This very important practical significance for control blood glucose treatment combined SARS-COV-2 infection.We search electronic databases...

10.1097/md.0000000000022587 article EN cc-by-nc Medicine 2020-10-28

Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications diabetic patients, which seriously affects quality life patients. At present, mainstream drugs have problems such as poor efficacy and side effects. Traditional Chinese medicine (TCM) has extensive clinical experience in prevention treatment diabetes complications, it also shows clear advantages DPN. Clinical studies confirmed that Danggui Sini decoction (DSD), a TCM decoction, can improve symptoms signs DPN...

10.1097/md.0000000000020482 article EN cc-by-nc Medicine 2020-05-22

Coronavirus disease 2019 (COVID-19) is a global pandemic caused by the severe acute respiratory syndrome coronavirus-2.COVID-19 highly pathogenic and infectious. COVID-19 epidemic still spreading all over world, there no sign of stopping at present. There specific cure for this disease, clinical management mainly depends on supportive treatment. Xiyanping widely used in treating China. However, evidence that effective safe COVID-19.

10.1097/md.0000000000022962 article EN cc-by-nc Medicine 2020-11-10

DM is a common chronic metabolic disease. COVID-19 large-scale infectious Some studies have shown that an independent risk factor increases mortality or other adverse outcomes. There currently no specific and effective drug treatment. More more people realize DPP-4 inhibitors may play huge role in fighting combined with diabetes. However, there evidence-based medicine to confirm the effectiveness safety of treatment patients Therefore, we will conduct systematic review meta-analysis...

10.1097/md.0000000000022592 article EN cc-by-nc Medicine 2020-10-06
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