A5101481433- Biochemical Analysis and Sensing Techniques
- Regulation of Appetite and Obesity
- Corneal Surgery and Treatments
- Carbohydrate Chemistry and Synthesis
- MicroRNA in disease regulation
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Diet and metabolism studies
- Congenital Heart Disease Studies
- Neuropeptides and Animal Physiology
- Acupuncture Treatment Research Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Olfactory and Sensory Function Studies
- Mesenchymal stem cell research
- Drug-Induced Hepatotoxicity and Protection
- Complementary and Alternative Medicine Studies
- Advanced Chemical Sensor Technologies
- Gastric Cancer Management and Outcomes
- Cardiovascular Conditions and Treatments
- Acute Kidney Injury Research
- Thermal Regulation in Medicine
- Catalytic Alkyne Reactions
- Natural Compounds in Disease Treatment
- Transcranial Magnetic Stimulation Studies
- Wireless Power Transfer Systems
Ruijin Hospital
2023-2024
Shanghai Jiao Tong University
2019-2024
Second Hospital of Yichang
2024
Shanghai First Maternity and Infant Hospital
2024
People's Hospital of Bishan District
2024
Chengdu University of Traditional Chinese Medicine
2020-2023
First Affiliated Hospital of Anhui Medical University
2023
Anhui Medical University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2021
Peking Union Medical College Hospital
2021
<b><i>Background/Aims: </i></b>Tempol is a protective antioxidant against ischemic injury in many animal models. The molecular mechanisms are not well understood. Nuclear factor erythroid 2-related (Nrf2) master transcription during oxidative stress, which enhanced by activation of protein kinase C (PKC) pathway. Another factor, tubular epithelial apoptosis, mediated phosphoinositide 3-kinase (PI3K)/protein B (PKB, Akt) signaling pathway renal injury. We tested the...
Abstract Triptolide, a key ingredient from the traditional Chinese medicinal plant thunder god vine, which has been used to treat inflammation and autoimmune diseases for centuries, shown be an irreversible inhibitor of XPB subunit transcription factor TFIIH initiation RNA polymerase II mediated transcription. The clinical development triptolide over past two decades limited by its toxicity low water solubility. Herein, we report glucose conjugate triptolide, named glutriptolide, was...
MicroRNAs (miRNAs) regulate gene expression by targeted repression of transcription and translation, are involved in carcinogenesis. In this study, we demonstrated that the miR‐454 was up‐regulated uveal melanoma tissues compared to normal tissues. Ectopic resulted significant promotion cell proliferation, colony formation, invasion induction cycle cells. Furthermore, identified PTEN as a direct target miR‐454. Our data revealed ectopic restored effects on proliferation These findings...
A new glycosylation protocol employing ortho-(methyltosylaminoethynyl)benzyl glycosides as glycosyl donors and TMSOTf the catalyst is disclosed. These can be readily prepared from corresponding 'latent' ortho-iodobenzyl via a Sonogashira coupling, thus providing approach for 'latent-active' synthesis of glycans.
Chemosensory signaling in organs such as the mouth and gut contributes to mechanisms that control metabolism. We investigated chemosensory pathways regulate secretion of hunger hormone ghrelin response neurotransmitters, bitter sweet tastants at cellular level human mucosa, disturbances this regulatory pathway induced by obesity. Obesity impaired protein production adrenalin-induced fundic cells, which was counterbalanced somatostatin. Bitter agonists selective for taste receptor type 2...
C-Glycosylation of glycosyl <italic>ortho</italic>-hexynylbenzoates with allyltrimethylsilane or silyl enol ethers could proceed smoothly under the catalysis Ph<sub>3</sub>PAuNTf<sub>2</sub>, wherein moisture sequestered by molecular sieves ensured gold(<sc>i</sc>)-catalytic cycle.
MicroRNAs (miRNAs/miRs) are important molecules that able to regulate multiple cellular processes in cancer cells. miR-7 has been previously identified as a tumor suppressive miRNA several types of cancer. The aim the present study was investigate whether is autophagy hepatocellular carcinoma (HCC) It significantly downregulated tissues compared with adjacent normal tissues. Overexpression inhibited cell proliferative activity, which partially reversed by inhibitor. In addition,...
To scientifically evaluate the intervention effect of Chinese medicine preventive administration(combined use Huo-xiang Zhengqi Oral Liquid and Jinhao Jiere Granules) on community population in case coronavirus disease 2019(COVID-19), a large cohort, prospective, randomized, parallel-controlled clinical study was conducted. Total 22 065 subjects were included randomly divided into 2 groups. The non-intervention group given health guidance only, while traditional medicine(TCM) two coordinated...
Scope The satiation properties of proteins involve effects on gut peptide release and gastrointestinal motility which may be altered during obesity. This study compares the in vitro response role amino acid (AA) taste receptors (TASR) effect AAs a casein hydrolysate ghrelin smooth muscle (SM) contractions proximal lean obese patients. Methods results Basal release, measured from mucosal segments, is maximal fundus decreased distally. Obesity selectively impaires stimulatory hydrolyaste but...
Objective. We aim to evaluate the impact of diabetes management shared care clinic (DMSCC) on glycated hemoglobin A1c (HbA1c) compliance and self-management abilities in patients with type 2 mellitus (T2DM). Methods. This study was a prospective cohort T2DM participating DMSCC. At baseline after management, HbA1c levels were measured, rate calculated, Summary Diabetes Self-Care Activities-6 (SDSCA-6), Empowerment Scale-DAWN Short Form (DES-DSF), Problem Areas Scale—Five-item (PAID-5)...
Photoaging is a degenerative biological process. As kind of pluripotent stem cells, adipose-derived cells (ADSCs) are widely used in the treatment photoaging. Therefore, we aimed to find an effective way improve antiaging ability ADSCs. In this study, isolated ADSCs and assessed multilineage differentiation markers. Cultured were preconditioned with astragaloside IV (ASI) at 10-7, 10-6, 10-5 M. Cell proliferation was by CCK-8 assay cytokine secretion enzyme-linked immunosorbent (ELISA). A...
Abstract Background: Colorectal cancer (CRC) is a public health problem and the world's leading killer. It disease with high incidence mortality. Although chemotherapy has achieved some success in treatment of CRC, drug resistance tumor metastasis caused by are still main causes death patients CRC. Notably, many side effects associated chemotherapy, such as nausea, vomiting, peripheral neurotoxicity, major challenges Chinese herbal medicine (CHM) been widely used an adjunctive therapy for...
Aims We aimed to investigate changes of fecal short chain fatty acids (SCFAs) and their association with metabolic benefits after sleeve gastrectomy (SG). Specifically, whether pre-surgery SCFAs modify surgical therapeutic effects was determined. Methods 62 participants measurements indices before 1, 3, 6 months SG were included. Changes post-surgery calculated. Then, stratified by medians modification on investigated, through calculating interaction group surgery. Results Fecal markedly...