A5101595490- Antimicrobial Resistance in Staphylococcus
- Plant-Microbe Interactions and Immunity
- Arsenic contamination and mitigation
- Antibiotics Pharmacokinetics and Efficacy
- Circular RNAs in diseases
- Melanoma and MAPK Pathways
- MicroRNA in disease regulation
- Viral-associated cancers and disorders
- Medicinal Plants and Bioactive Compounds
- Plant Gene Expression Analysis
- Saffron Plant Research Studies
- RNA Interference and Gene Delivery
- Microbial Community Ecology and Physiology
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Ion Transport and Channel Regulation
- Parvovirus B19 Infection Studies
- Obesity, Physical Activity, Diet
- Vestibular and auditory disorders
- Methane Hydrates and Related Phenomena
- Immune Response and Inflammation
- Environmental DNA in Biodiversity Studies
- Chromium effects and bioremediation
- Tea Polyphenols and Effects
- Telomeres, Telomerase, and Senescence
Hangzhou Normal University
2015-2025
Nanjing Medical University
2022-2025
First Affiliated Hospital of Fujian Medical University
2025
Fujian Medical University
2025
Shenyang Aerospace University
2024
Institute of Oceanology
2022-2024
Suzhou Municipal Hospital
2022-2023
University of Chinese Academy of Sciences
2022-2023
Shaanxi Normal University
2023
Southwest Jiaotong University
2022
Cardiovascular-kidney-metabolic (CKM) syndrome and systemic inflammation significantly contribute to mortality. However, the joint associations of CKM stages with all-cause cardiovascular disease (CVD) mortality remain unclear. This study aimed evaluate independent CVD in a representative cohort United States adults. We analyzed data from 29,459 adults aged ≥ 20 years National Health Nutrition Examination Survey (1999–2018). were classified based on metabolic risk factors, CVD, chronic...
Liver injury is a major complication associated with sepsis. Together others, the study has shown that gallic acid (GA) exerts anti-inflammatory and antioxidant effects in vivo. However, role of GA sepsis-mediated hepatic impairment underlying mechanisms remains to be elucidated.
To evaluate the safety and efficacy of area reduction post-closure technique for bedside weaning veno-arterial extracorporeal membrane oxygenation (V-A ECMO). A retrospective study was conducted from December 2022 to November 2023, analyzing data patients who underwent V-A ECMO at our center. The technique, utilizing two ProGlide devices (Abbott Vascular, Santa Clara, CA), adopted as a standard practice. technical success defined achieving complete hemostasis without bailout open repair....
Dietary phytoestrogens have been suggested to provide protection against numerous age-related diseases. However, their effects on biological aging remain unclear. In this study, we cross-sectionally investigated the relationship between urinary phytoestrogen levels and indicators of using data from 7,981 adults who participated in National Health Nutrition Examination Survey 1999–2010. Urinary concentrations six phytoestrogens, including four isoflavones two enterolignans, were measured...
Sensorineural hearing loss (SNHL) poses a significant global health challenge with substantial socioeconomic and medical implications. The pathophysiology involves excessive reactive oxygen species (ROS) in the cochlea, inflammation, cellular apoptosis, etc. Tryptophan metabolite indole-3-propionic Acid (IPA), produced by gut microbiota, may offer therapeutic benefits modulating oxidative stress, immune responses. However, roles of IPA protecting from treatment adult mice remain to be...
Abstract Per- and polyfluoroalkyl substances (PFASs) are known as " forever chemical ", commonly used in commercial daily-life products. Due to their special physico-chemical characteristics, PFASs have been found various environmental matrices, can be exposed organisms humans. The present review outlines the current state of knowledge on occurrence environment, human exposure routes, biomonitoring data, metabolic mechanism. Diet is considered main route exposure, these compounds enter body...
F-box proteins play important roles in plant growth/development and responses to environmental stimuli through targeting substrates into degradation machinery. A rice defense-related protein gene, OsDRF1, was cloned identified during a course of study aimed at elucidating the molecular basis induced immunity rice. OsDRF1 encodes 328 amino acids, containing highly conserved domain. Expression upon treatment with benzothiadiazole (BTH), chemical inducer defense Moreover, BTH-treated seedlings,...
Abstract Translatable circular RNAs (circRNAs) are emerging as a crucial molecular format for transient protein expression, with high potential to be an alternative linear mRNA reshape the landscape of pharmaceutical industry. Canonical Anabaena permuted intron-exon ( Ana PIE) that developed by ORNA is efficient method RNA circularization, and engineered circRNAs direct supreme expression in eukaryotic cells. However, recent studies revealed this may unavoidably result remain immunogenicity...
Objectives Peripheral leucocyte telomere length has been suggested to be inversely associated with hypertension risk. Both and risk can modified by certain dietary factors, such as fruit vegetables. This study was examine the potential effect of these factors on association between Study design A community-based case–control study. Participants 271 hypertensive patients 455 normotensive controls aged 40–70 years living in Yinzhou, Zhejiang Province, China. Outcome measures relative (RTL)...
Foraminiferal environmental DNA (eDNA) is an efficient and reliable indicator of changes. Here, we investigated the foraminiferal diversity 25 stations (33–36°N) in Yellow Sea based on eDNA presented first assessment correlations between foraminifera conditions region. A total 71 sediment samples were collected local parameters measured. The was extracted from part small subunit (SSU) rRNA gene amplified samples. After high–throughput sequencing, 1,701,899 reads detected clustered into 426...
Ocean acidification (OA) is a persistent challenge for humans and predicted to have deleterious effects on marine organisms, especially calcifiers such as coral foraminifera. Benthic foraminifera an important component of sediment in the continental shelf, while little known about impact ocean benthic both at community individual level associated calcium carbonate deposition. We conducted eight months continued culture experiment under scenario 400, 800, 1200 1600 ppm pCO2 gradients living...
Cisplatin is a first-line chemotherapeutic agent for the treatment of many types cancer, but emergence chemoresistance hinders its application. Thus, better understanding cisplatin-induced DNA damage response (DDR) would help to overcome this problem. Previously, we have identified panel microRNAs with altered expression after cisplatin in HeLa cells. In current study, focused on one them, miR-191, and investigated function DDR. We found that overexpression miR-191 sensitized cells cytotoxic...
Linezolid-induced thrombocytopenia is the main factor restricting clinical application of linezolid.To investigate relationship between PNU-14230 concentration and linezolid-induced further develop validate a risk model for predicting thrombocytopenia.A regression was constructed to predict occurrence thrombocytopenia, externally validated. The predictive performance evaluated by receiver operating characteristic curve Hosmer-Lemeshow test. Linezolid Cmin PNU-142300 concentrations were...
Kaposi's sarcoma‐associated herpesvirus (KSHV) may be transmitted via sexual contacts, but limited information is available on KSHV infection status among sexually (STI) patients in China. The main objective of the present study was to determine seroprevalence and its risk factors male STI patients. A cross‐sectional survey conducted three prefectures Anhui province, China, between June September 2013. total 1,600 who visited an clinic were invited, 1,372 participated study. Data abstracted...
Previously, we have shown that paraspeckle protein 1 (PSPC1), a component of paraspeckles was involved in cisplatin-induced DNA damage response (DDR), probably functions at the G1/S checkpoint. In current study, further examined role PSPC1 another DNA-damaging agent, methyl methanesulfonate (MMS)-induced DDR, particular, focusing on MMS-induced apoptosis HeLa cells. First, it found MMS treatment induced expression PSPC1. While alone can induce apoptosis, depletion using siRNA significantly...
The electronic properties of hydrogen-terminated biphenylene (BP) segments different sizes on the sub-nanoscale are explored, and energy gap is observed to follow a linear relationship with hydrogen-to-carbon ratio segments.
Arsenic-based therapeutic strategies, even though promising for acute promyelocytic leukemia (APL), are limited by arsenic-related toxic effect and resistance with unknown mechanisms. The purpose of this study is to better understand the different sensitivities hepatocellular carcinoma cells arsenic its mechanism. Arsenic-sensitive liver cancer cell line (HepG2) arsenic-resistant HepG2 (AsHepG2) employed role aquaporin 9 (AQP9) in uptake tolerance. half-maximal inhibitory concentration...