A5100392120- Advanced Glycation End Products research
- Immune Response and Inflammation
- Plant Virus Research Studies
- Autophagy in Disease and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
- S100 Proteins and Annexins
- Protein Hydrolysis and Bioactive Peptides
- Nematode management and characterization studies
- Nitrogen and Sulfur Effects on Brassica
- Respiratory Support and Mechanisms
- Fatty Acid Research and Health
- Plant Disease Resistance and Genetics
- Amino Acid Enzymes and Metabolism
- Cholesterol and Lipid Metabolism
- Immunotherapy and Immune Responses
- Alcohol Consumption and Health Effects
- Entomopathogenic Microorganisms in Pest Control
- Insect Resistance and Genetics
- Plant Molecular Biology Research
- Neuroscience of respiration and sleep
- Plant-Microbe Interactions and Immunity
- Inflammatory mediators and NSAID effects
Air Force Medical University
2023
Xijing Hospital
2023
Shanghai Sixth People's Hospital
2022-2023
Virginia Tech
2020-2022
Dalian Ocean University
2022
Tongji University
2022
Qingdao National Laboratory for Marine Science and Technology
2022
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2022
Soochow University
2019
First Affiliated Hospital of Soochow University
2019
As the essential amino acids, branched-chain acid (BCAA) from diets is indispensable for health. BCAA supplementation often recommended patients with consumptive diseases or healthy people who exercise regularly. Latest studies and ours reported that elevated level was positively correlated metabolic syndrome, diabetes, thrombosis heart failure. However, adverse effect of in atherosclerosis (AS) its underlying mechanism remain unknown. Here, we found plasma an independent risk factor CHD by...
Abstract Autophagy and pyroptosis of macrophages play important protective or detrimental roles in sepsis. However, the underlying mechanisms remain unclear. High mobility group box protein 1 (HMGB1) is associated with both autophagy. lipopolysaccharide (LPS) an pathogenic factor involved Lentivirus-mediated HMGB1 shRNA was used to inhibit expression HMGB1. Macrophages were treated acetylation inhibitor (AA) suppress translocation from nucleus cytosol. pyroptosis-related expressions detected...
Plant NLR-type receptors serve as sensitive triggers of host immunity. Their expression has to be well-balanced, due their interference with various cellular processes and dose-dependency defense-inducing activity. A genetic "arms race" fast-evolving pathogenic microbes requires plants constantly innovate NLR repertoires. We previously showed that insertion the COPIA-R7 retrotransposon into RPP7 co-opted epigenetic transposon silencing signal H3K9me2 a new function promoting this Arabidopsis...
High-mobility group box 1 (HMGB1) protein is released into the serum after tissue damage, and serves as a warning signal to enhance inflammatory response. Acute liver injury one of diseases that starts with damage ends systemic inflammation. We used D-(+)-galactosamine hydrochloride (D-GalN)/lipopolysaccharide (LPS)-treated mice an acute model explore functions HMGB1 in more detail. at very early stage D-GalN/LPS-induced injury. It upregulates expression tumor necrosis factor-α (TNF-α),...
Cytochrome P450 genes are very important for plant-parasitic nematodes to reproduce and metabolize xenobiotic compounds generated by their host plants. The pine wood nematode (PWN), Bursaphelenchus xylophilus, causes high annual economic losses killing large numbers of trees across Asia into Europe. In this study, we used RNA interference (RNAi) analyze the function cyp-33C9 gene PWN. Our results showed that expression was suppressed successfully after soaking 24 h in double-stranded...
Abstract Introduction Kawasaki disease (KD), an acute febrile disease, characterized by systemic vasculitis, predominantly affects infants and children under 5 years of age. Coronary artery lesions (CALs) are its most critical complication, the etiology remains unknown yet. In order to explore value resistin, S100A12 soluble receptor for advanced glycation end products (sRAGE) in pathophysiology KD, we studied serum levels sRAGE different stages KD. Methods Serum were measured enzyme-linked...
Abstract Autophagy and pyroptosis of macrophages play important protective or detrimental roles in sepsis. However, the underlying mechanisms remain unclear. High mobility group box protein 1 (HMGB1) is associated with both autophagy. lipopolysaccharide (LPS), an pathogenic factor involved Lentivirus-mediated HMGB1 shRNA was used to inhibit expression HMGB1. Macrophages were treated acetylation inhibitor (AA) suppress translocation from nucleus cytosol. pyroptosis-related expressions...
Objective To investigate the mechanism of extracellular high mobility group box 1 (HMGB-1) -induced inflammatory response in normal human bronchial epithelial cells (NHBE) . Methods The subjects were divided into control group, HMGB-1 HMGB-1+RAGE antibody (RAGE-Ab) HMGB-1+JNK inhibitor SP600125 and RAGE-Ab group. Immunofluorescence technique was used to analyze expression RAGE protein. ELISA assay determine levels cytokines TNF-α, IL-8, IL-10 MCP-1 NHBE cell supernatant. Western...