A5103184577- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Congenital Diaphragmatic Hernia Studies
- Respiratory Support and Mechanisms
- Cancer therapeutics and mechanisms
- Clinical Nutrition and Gastroenterology
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Immune Cell Function and Interaction
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- Cancer Immunotherapy and Biomarkers
- Microtubule and mitosis dynamics
- PARP inhibition in cancer therapy
- Pediatric Hepatobiliary Diseases and Treatments
- Ubiquitin and proteasome pathways
- Pleural and Pulmonary Diseases
- Congenital Anomalies and Fetal Surgery
- Protein Hydrolysis and Bioactive Peptides
- NF-κB Signaling Pathways
- Lung Cancer Treatments and Mutations
- T-cell and B-cell Immunology
- MicroRNA in disease regulation
- Melanoma and MAPK Pathways
Shandong Tumor Hospital
2024
Shandong First Medical University
2024
Chongqing Medical University
2010-2024
University of Hawaiʻi at Mānoa
2024
Guangdong Provincial Hospital of Traditional Chinese Medicine
2023
Chongqing University of Technology
2022
China International Science and Technology Cooperation
2019-2022
Children's Hospital of Chongqing Medical University
2007-2022
Xi'an Jiaotong University
2018-2021
Guiyang Medical University
2019
Insights from cell cycle research have led to the hypothesis that tumors may be selectively sensitized DNA-damaging agents resulting in improved antitumor activity and a wider therapeutic margin. The theory relies on observation majority of are deficient G1-DNA damage checkpoint pathway reliance S G2 checkpoints for DNA repair survival. regulated by kinase 1, serine/threonine is activated response damage; thus, inhibition 1 signaling impairs increases tumor death. Normal tissues, however,...
Objective.Previous studies have shown that inhibiting T cell DNA methylation causes a lupus-like disease by modifying gene expression.T cells from patients with lupus exhibit diminished levels of methyltransferase (MTase) enzyme activity, hypomethylated DNA, and changes in expression similar to those exhibited treated inhibitors, suggesting hypomethylation may contribute human lupus.Since it is known MTase are regulated the ras-mitogen-activated protein kinase (MAPK) pathway, this study...
Abstract Objective Generalized DNA hypomethylation contributes to altered T cell function and gene expression in systemic lupus erythematosus (SLE). Some of the overexpressed genes participate disease process, but full repertoire affected is unknown. Methylation‐sensitive were identified by treating cells with methyltransferase inhibitor 5‐azacytidine comparing oligonucleotide arrays. CD70, a costimulatory ligand for B CD27, was one that reproducibly increased. We then determined whether...
Checkpoint kinases CHK1 and CHK2 are activated in response to DNA damage that results cell cycle arrest, allowing sufficient time for repair. Agents lead abrogation of such checkpoints have potential increase the efficacy compounds as chemo- radiotherapies. Thiophenecarboxamide ureas (TCUs) were identified inhibitors by high throughput screening. A structure-based approach is described using crystal structures JNK1 complex with 1 2 CHK1-3b complex. The ribose binding pocket was targeted...
Acute effects of oxidative damage induced by benzo[a]pyrene (B[a]P) on various organs are still not clear. In this study, we investigated stress and DNA in liver, lung, stomach, brain kidney ICR male mice acute B[a]P treatment. treatment led to a significant decrease at the different doses body weight. For variations superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), (GSH) GSH/GSSG, increases were observed 24 h, then decreased till 72 h after injection. The increase...
Abstract Background: The aim of the present study was to explore incidence and risk factors of, summarize involved pathogens in, neonates with ventilator‐associated pneumonia (VAP) in authors' neonatal intensive care unit (NICU) determine effective strategies for prevention. Methods: A retrospective case–control including 117 VAP patients 232 controls conducted from January 2002 July 2008. antibiotics sensitivity spectrum determined on quantitative microbiological evaluation. Multiple...
IL-1β creates persistent pulmonary inflammation accompanied by elevated transforming growth factor β (TGF-β levels and is associated with abnormal elastogenesis, which observed in bronchopulmonary dysplasia (BPD). Although progress has been made this field, the mechanisms underlying process remain only partially understood.We assessed aberrant elastin localization-associated signaling mouse pups exposed to 85% O2 treated either IL-1Ra or 1D11, using morphometric analyses, quantitative...
Intestinal stricture is a severe and common complication of necrotizing enterocolitis (NEC), causing prolonged morbidity. Our goal was to investigate the clinical predictors for strictures developing after NEC evaluate management outcome post-NEC better orient their medicosurgical care. A total 188 patients diagnosed with identical treatment protocols throughout period under study were retrospectively reviewed from 4 academic neonatal centers between January 1, 2011, October 31, 2016....
Checkpoint kinase 1 (CHK1) inhibitors are potential cancer therapeutics that can be utilized for enhancing the efficacy of DNA damaging agents. Multiple small molecule CHK1 from different chemical scaffolds have been developed and evaluated in clinical trials combination with chemotherapeutics radiation treatment. Scaffold morphing thiophene carboxamide ureas (TCUs), such as AZD7762 (1) a related series triazoloquinolines (TZQs), led to identification fused-ring bicyclic inhibitors,...
We sought to determine whether the extrapulmonary origin of fibroblasts derived from bone marrow (BM) progenitor cells is essential lung fibrosis in bronchopulmonary dysplasia (BPD). Neonate mice were durably engrafted with BM isolated transgenic reporter that expressed green fluorescent protein (GFP). Such chimera subjected 60% O(2) exposure for 14 days. A large number fibroblast-specific protein-1 (FSP1) and GFP-positive identified active fibrotic lesions. More surprisingly, however,...
Although high-mobility group box-1 (HMGB1) levels in tracheal aspirates are associated with the pathological features of bronchopulmonary dysplasia (BPD), role HMGB1 terminal stage abnormal alveologenesis has not yet been understood. In this study, we addressed elastogenesis disruption lungs newborn mice BPD. We found that elevations whole lung level were impaired alveolar development and aberrant elastin production 85% O2-exposed lungs. neutralizing antibody attenuated structural...
Abnormal alveolar formation and excessive disordered elastin accumulation are key pathological features in bronchopulmonary dysplasia. Transforming growth factor (TGF)-β is an important regulator of the extracellular matrix developing lung. To determine if increased TGF-β would injure development by activating signaling influencing expression elastogenesis-related protein, we performed intraperitoneal injection newborn mice with TGF-β-neutralizing antibody 1D11 observed whether had a...
Although sorafenib (Sor) is the only effective drug for hepatocellular carcinoma (HCC), its therapeutic potential to date mainly limited low tumor response. This study was designed explore whether resveratrol (Res) could potentiate anticancerous activity of Sor. We used HepG2 and Huh7 HCC cell lines BALB/c nude mice in vitro vivo studies, respectively. The cultured induction were treated with different concentrations Res Sor alone, combination observe antitumor effects. Significant...
We examined whether low dose radiation (LDR) exposure (75 mGy) could increase the therapeutic efficacy of cyclophosphamide (CTX) by comparing effects tumor suppression, cell apoptosis, cycle and proliferation bone marrow in vivo. Kunming mice implanted with S180 sarcoma cells were given 75 mGy whole body γ-ray CTX (300 mg/kg) intraperitoneal injection 36 hours after LDR. Proliferation was analyzed flow cytometry. Cytochrome c leakage from measured Western-blot. discovered that growth...
Fibrocytes, ahematopoietic stem cell source of fibroblasts/myofibroblasts, were previously implicated to infiltrate into the intestinal and enhance inflammation.The aims present study elucidate role fibrocytes in necrotizing enterocolitis (NEC) pathogenesis explore mechanisms by which contributed inflammatory responses.We investigated circulating local from 32 patients with NEC, 8 noninflammatory conditions gastrointestinal tract 12 normal subjects.Significantly higher numbers found...