A5066508839- Dialysis and Renal Disease Management
- Potassium and Related Disorders
- Central Venous Catheters and Hemodialysis
- Acute Kidney Injury Research
- Cardiovascular Function and Risk Factors
- Chronic Kidney Disease and Diabetes
- Cardiac Imaging and Diagnostics
- MRI in cancer diagnosis
- Electrolyte and hormonal disorders
- Bipolar Disorder and Treatment
- Membrane-based Ion Separation Techniques
- Advanced MRI Techniques and Applications
- Social and Behavioral Studies
- Muscle and Compartmental Disorders
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Heart Failure Treatment and Management
- Radiomics and Machine Learning in Medical Imaging
- Erythropoietin and Anemia Treatment
- Biomedical Research and Pathophysiology
- Renal Diseases and Glomerulopathies
- Heme Oxygenase-1 and Carbon Monoxide
- Blood donation and transfusion practices
- Gout, Hyperuricemia, Uric Acid
- Pharmacy and Medical Practices
Jiangmen Central Hospital
2021-2024
Renji Hospital
2016-2024
Shanghai Jiao Tong University
2016-2024
Shanghai Cell Therapy Research Institute
2024
Lehigh University
2014
Contrast-induced acute kidney injury (CI-AKI) occurs in more than 30% of patients after intravenous iodinated contrast media and causes serious complications, including renal failure mortality. Recent research has demonstrated that routine antioxidant alkaline therapy failed to show benefits CI-AKI with high risk for complications. Mitophagy is a mechanism selective autophagy, which controls mitochondrial quality reactive oxygen species (ROS) through degradation damaged mitochondria. The...
The pathogenetic mechanism of contrast-induced acute kidney injury (CI-AKI), which is the third most common cause hospital-acquired AKI, has not been elucidated. Previously, we demonstrated that renal and cell apoptosis were attenuated in nlrp3 knockout CI-AKI mice. Here, investigated underlying NLRP3 inhibition-mediated attenuation CI-AKI. RNA sequencing analysis cortex revealed or casp1 mice exhibited upregulated cellular response to hypoxia, mitochondrial oxidation, autophagy when...
Cisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing incidence cisplatin-induced acute kidney injury. Mitophagy a type mitochondrial quality control mechanism that degrades damaged mitochondria and maintains cellular homeostasis. Ferroptosis, new modality programmed cell death, characterized by iron-dependent phospholipid peroxidation oxidative membrane damage. However, role mitophagy ferroptosis disease unclear. Here, we investigated...
Mitophagy is a principle mechanism to degrade damaged mitochondria through PARK2-dependent or PARK2-independent pathway. has been identified play an important role in acute kidney disease, whereas its renal fibrosis remains ill-defined. We sought investigate the involvement and regulation of mitophagy tubular epithelial cell(RTEC) injury after unilateral ureteral obstruction(UUO). Mitochondrial damageand mitochondrial reactive oxygen species (ROS) production was increased obstruction left...
Background Several studies have suggested that urgent-start peritoneal dialysis (PD) is a feasible alternative to hemodialysis (HD) in patients with end-stage renal disease (ESRD), but the impact of modality on outcome, especially short-term complications, has not been directly evaluated. The aim current study was compare complications and outcomes PD HD ESRD patients. Methods In this retrospective study, who initiated urgently without pre-established functional vascular access or catheter...
Peritoneal dialysis (PD) shows promise for urgent-start in end-stage renal disease (ESRD), with automated PD (APD) having advantages. However, there is limited multicenter randomized controlled trial (RCT) evidence comparing APD temporary hemodialysis (HD) this indication China.
Acute kidney injury (AKI) constitutes a prevalent clinical syndrome characterized by elevated morbidity and mortality rates, emerging as significant public health issue. This study investigates the interplay between endoplasmic reticulum (ER) stress, unfolded protein response (UPR), ER-associated degradation (ER-phagy) in pathogenesis of AKI. We employed four distinct murine models AKI-induced contrast media, ischemia-reperfusion injury, cisplatin, folic acid-to elucidate relationship...
Patients with end-stage renal disease (ESRD) frequently require urgent-start dialysis. Recent evidence suggests that peritoneal dialysis (PD) might be a feasible alternative to hemodialysis (HD) in these patients, including older patients.This retrospective study enrolled patients aged > 65 years ESRD who underwent urgent without functional vascular access or PD catheter at single center, from January 2011 December 2014. were grouped based on their modality (PD HD). unable tolerate insertion...
<b><i>Aims:</i></b> This study aimed to compare the short-term complications and long-term prognosis between urgent-start peritoneal dialysis (PD) hemodialysis (HD), explore safety feasibility of PD in end-stage renal disease (ESRD) patients with diabetes. <b><i>Methods:</i></b> retrospective enrolled ESRD diabetes who required at a single center from January 2011 December 2014. Short-term (30-day) dialysis-related patient survival trends were...
Renal anemia is one of the most important complications in patients on maintenance hemodialysis (MHD). Telehealth-based dialysis registration systems have advantage real-time monitoring and gradually been applied to management chronic diseases.The objective our study was evaluate impact a telehealth-based system MHD terms renal control.The Red China project aimed develop based WeChat mobile platform. Demographic baseline laboratory parameters such as age, gender, primary disease, creatinine...
The complexity of left ventricular (LV) trabeculae is related to the prognosis several cardiovascular diseases.
The rapid development of artificial intelligence (AI) has shown great potential in medical document generation. This study aims to evaluate the performance Claude 3.5-Sonnet, an advanced AI model, generating discharge summaries for patients with renal insufficiency, compared human physicians.
Hyperkalaemia is a known risk factor for cardiac arrhythmia and mortality in patients on haemodialysis. Despite standard adequate haemodialysis, hyperkalaemia common with end-stage renal disease (ESRD) at interdialytic intervals. Data burden its effects dialysis patterns serum potassium (sK) fluctuations haemodialysis China remain limited. The prospective, observational cohort study (PRECEDE-K; NCT04799067) investigated the prevalence, recurrence, treatment of Chinese ESRD haemodialysis.Six...
Background Left ventricular global function index (LVGFI) integrates LV volumetric and functional parameters. In patients with end‐stage renal disease (ESRD), cardiac injury manifests as hypertrophy dysfunction. However, the prognostic value of LVGFI in this population remains unclear. Purpose To investigate association major adverse events (MACE) ESRD. Study Type Prospective. Population One hundred fifty‐eight ESRD (mean age: 54.1 ± 14.4 years; 105 male) on maintenance dialysis. Filed...
Background Diastolic dysfunction (DD) frequently occurs in dialysis patients; however, the risk factors of DD remain to be further explored such a population. Epicardial adipose tissue (EAT) volume has proven an independent clinical factor for multiple cardiac disorders. Purpose To assess whether EAT is patients. Study Type Case–control study. Population A total 113 patients (mean age: 54.5 ± 14.4 years; 41 women) who had underwent at least 3 months due uremia. Field Strength T, steady‐state...
Recent evidence suggests that automated peritoneal dialysis (APD) might be a feasible alternative to hemodialysis (HD) in urgent-start dialysis.This prospective study enrolled end-stage renal disease (ESRD) patients who had started APD as an modality at single center. Dialysis-related complications were recorded. Dialysis adequacy and electrolytes imbalance compared between baseline, 14 42 days after catheter insertion. Technique survival patient also recorded.A total of 36 included the...
Background Vertical run‐length nonuniformity (VRLN) is a texture feature representing heterogeneity within native T1 images and reflects the extent of cardiac fibrosis. In uremic cardiomyopathy, interstitial fibrosis was major histological alteration. The prognostic value VRLN in patients with end‐stage renal disease (ESRD) remains unclear. Purpose To evaluate MRI ESRD. Study Type Prospective. Population A total 127 ESRD (30 participants adverse events, MACE group). Field Strength/Sequence...
We aimed to explore factors associated with mortality of diabetic kidney disease (DKD), and establish a prediction model for predicting the DKD. This was cohort study. In total, 1,357 DKD patients were identified from Medical Information Mart Intensive Care IV (MIMIC-IV) database, 505 being MIMIC-III as testing set. The outcome study 1-year mortality. COX proportional hazard models applied screen predictive factors. conducted based on A receiver operating characteristic (ROC) curve area...
The contrast-induced acute kidney injury (CI-AKI) has been becoming the third common cause of hospital-acquired injury. An ideal animal model is essential for understanding pathophysiology CI-AKI. Previous CI-AKI studies were mostly performed on rats with high-osmolar contrast medium (HOCM), which unsuitable transgenic researches. This study provides a novel, efficient and reproducible was developed in mouse by administrating low-osmolar (LOCM). First all, we applied frequently used...
Abstract Background Noncontrast cardiac T 1 times are increased in dialysis patients which might indicate fibrotic alterations uremic cardiomyopathy. Purpose To explore the application of texture analysis (TA) images assessment myocardial patients. Study Type Case–control study. Population A total 117 subjects, including 22 on hemodialysis, 44 peritoneal dialysis, and 51 healthy controls. Field Strength 3 T, steady‐state free precession (SSFP) sequence, modified Look–Locker imaging (MOLLI)....