A5088019460- Renal Diseases and Glomerulopathies
- Potassium and Related Disorders
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Bipolar Disorder and Treatment
- Galectins and Cancer Biology
- Diabetes Treatment and Management
- Pediatric Urology and Nephrology Studies
- Membrane-based Ion Separation Techniques
- Chronic Kidney Disease and Diabetes
- Renal cell carcinoma treatment
- Pancreatic function and diabetes
- Endometriosis Research and Treatment
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Vestibular and auditory disorders
- Electrolyte and hormonal disorders
- Kidney Stones and Urolithiasis Treatments
- Polyamine Metabolism and Applications
- COVID-19 Impact on Reproduction
- Biomedical Research and Pathophysiology
- IL-33, ST2, and ILC Pathways
- Wnt/β-catenin signaling in development and cancer
- Heart Failure Treatment and Management
- Cancer Mechanisms and Therapy
Shanxi Academy of Medical Sciences
2017-2024
Huazhong University of Science and Technology
2024
Shanxi Medical University
2010-2024
Fudan University
2024
Tongji Hospital
2024
Renmin Hospital of Wuhan University
2020-2023
Wuhan University
2020-2023
Shanxi Dayi Hospital
2014-2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2012
Second Hospital of Shanxi Medical University
2011
A novel and highly pathogenic coronavirus (2019-nCoV)-induced pneumonia spread worldwide in a short time. However, studies on the effects of 2019-nCoV male reproductive system are limited. The aim this study is to describe clinical characteristics COVID-19 patients explore presence semen. Retrospective, single-center case series 112 with confirmed who were admitted Renmin Hospital Wuhan University from January 2 March 7, 2020. Demographic data, symptoms signs related system, throat swabs...
The increased activity of the mTOR pathway in bladder cancer has been extensively studied, but no satisfactory inhibitor found cancer. role AZD8055, a second-generation inhibitor, not reported Herein, we investigated effects AZD8055 on cells and their interaction with macrophages vivo vitro. In four cell lines, phosphorylation mTOR, AKT S6K1 was suppressed by AZD8055. inhibited proliferation induced G1 cell-cycle arrest apoptosis concentration-dependent manner. also inhibits migration...
Increasing evidence shows that the abnormal long non-coding RNAs (lncRNAs) expression is closely related to ischemia-reperfusion injury (I/R) progression. Studies have previously described lncRNA MEG3 regulates pyroptosis in various organs I/R. Nevertheless, mechanisms of testicular I/R has not been clarified. The aim this research unravel underlying regulation mediated by during We established a torsion/detorsion (T/D) model and an oxygen-glucose deprivation/reperfusion (OGD/R)-treated...
Cisplatin is the first-line chemotherapy for advanced or metastatic bladder cancer. Nevertheless, approximately half of patients with BCa are insensitive to cisplatin therapy develop resistance during treatment process. Therefore, it especially crucial investigate ways enhance sensitivity tumor cells cisplatin. Transcription factor AP-2 gamma (TFAP2C) involved in cancer development and sensitivity. However, its relationship has not been studied BCa. In this study, we aimed therapeutic...
Introduction Emerging research suggests that sodium-glucose cotransporter 2 (SGLT2) inhibitors may play a pivotal role in the treatment of primary glomerular diseases. This study was aimed to investigate potential pharmacological targets connecting SGLT2 with IgA nephropathy (IgAN) and membranous (MN). Methods A univariate Mendelian randomization (MR) analysis conducted using publicly available genome-wide association studies (GWAS) datasets. Co-localization used identify connections between...
To investigate the effect of sitagliptin on Wnt/β-catenin signalling in tubulointerstitium diabetic nephropathy.Forty male Wistar rats were divided into normal control (NC), model (DM), low and high-dose intervention groups (ST1 ST2, respectively). Changes biochemical parameters tubulointerstitial fibrosis index observed. The levels protein gene expression different indicators detected via immunohistochemistry real-time polymerase chain reaction. NRK-52E cells group, mannitol high glucose...
LncRNA have been increasingly shown that plays pivotal roles in the development of various diseases, including renal fibrosis. Nevertheless, pathological function Long non-coding RNA KCNQ1OT1 (KCNQ1OT1) fibrosis remains obscure. Unilateral ureteral obstruction (UUO) was used to induce We detected expression levels TGF-β1-induced HK-2 cells via RT-qPCR analysis. The functions on progression were examined by CCK-8, EdU, dual-luciferase reporter, and immunofluorescence analyses. In present...
Study has demonstrated the abnormal expression and role of lncRNA CASC15 in diabetes patients with chronic renal failure. However, its nephropathy (DN) is still unclear. This study aimed to investigate potential mechanism DN. The relationship between miR-424 CASC15/SP-A was predicted by Starbase software verified luciferase reporter assay. HK-2 cells were treated 25 mM glucose (HG) for 24 h establish DN cell model. MTT flow cytometry analysis carried out test proliferation apoptosis....
Hyperkalaemia is a known risk factor for cardiac arrhythmia and mortality in patients on haemodialysis. Despite standard adequate haemodialysis, hyperkalaemia common with end-stage renal disease (ESRD) at interdialytic intervals. Data burden its effects dialysis patterns serum potassium (sK) fluctuations haemodialysis China remain limited. The prospective, observational cohort study (PRECEDE-K; NCT04799067) investigated the prevalence, recurrence, treatment of Chinese ESRD haemodialysis.Six...
To further reveal the effects of leflunomide on renal protection and inflammatory response using streptozotocin (STZ) induced diabetic rats.Male Wistar rats were randomly divided into normal control group (NC), (DM) treatment (LEF). LEF given (5 mg/kg) once daily. At end 12th week, general biochemical parameters in three groups determined. The histopathology was observed by light microscopy electron microscopy. Further analysis gene protein expression nuclear factor kappa B (NF-κB), tumour...
The protective effects of sitagliptin on the kidneys rats with diabetic nephropathy (DN) and its influence extracellular signal-regulated kinases 1/2 (ERK1/2) signaling were investigated. Male Wistar (n = 40) randomly assigned to normal control, DN, low-dose intervention (ST1), or high-dose (ST2) groups. Animals euthanized after a 16-week treatment, blood glucose (BG), glycosylated hemoglobin (HbA1c), urinary albumin excretion rate (AER), serum creatinine (Scr), clearance (Ccr), active...
Abstract Background Minimal change disease (MCD), a pathological type of nephrotic syndrome (NS), can occur in patients with tumors. We report two adult cases MCD associated papillary thyroid carcinoma (PTC), known to be extremely rare adults. Case presentation A 35-year-old female patient was simultaneously diagnosed and PTC. The effectively treated thyroidectomy prednisone.In addition, 50-year-old male patient, who had been PTC three years prior, confirmed by renal biopsy. achieved...
Renal fibrosis is a significant characteristic of chronic kidney diseases. Surfactant protein A (SP‑A) recently identified fibrosis‑associated factor in lung fibrosis; however, whether SP‑A has the same role renal remained elusive. The aim present study was to investigate and its receptor calreticulin (CRT) pathogenesis fibrosis. HK‑2 human tubular epithelial cell line cultured treated with + anti‑CRT. production reactive oxygen species (ROS) at 30, 60 120 min examined. Furthermore,...
Hyperkalaemia (HK) is a potentially life-threatening electrolyte imbalance associated with several adverse clinical outcomes and common in patients kidney failure. However, there no evidence on the occurrence, recurrence treatment of HK haemodialysis (HD) China.The Prevalence, Recurrence, Treatment Haemodialysis Study prospective, multicentre, observational, cohort study being conducted across 15-18 sites China. Approximately 600 end-stage disease HD are anticipated to be enrolled will...
Patients with end-stage renal disease (ESRD) on hemodialysis (HD) are at risk for hyperkalemia (HK), associated cardiac arrhythmia and sudden death. Data the burden of HK management techniques among HD patients in China still scarce. This study assessed treatment modalities, recurrence, prevalence Chinese patients.
Hemodialysis (HD) patients represent a high-risk group for hepatitis B infection. It is crucial to administer vaccination and stimulate higher more sustained levels of anti-HBs. Our aim enhance the immunogenicity persistence by implementing high-dose prolonged vaccine schedule regimen in HD patients.
To study the effect of metanephric mesenchyme cells on podocytes apoptosis induced by high glucose.Mice's podocyte was cultured in vitro,and and injury model then established glucose (30 mmol/L) induction. Metanephric were extracted from E13.5 mouse embryos used to make conditioned medium which treat apoptosis. The flow cytometry confocal fluorescence imaging detect ratio cytoskeletal protein (synaptopodin) expression at several time points (24, 48, 72 h), order explore treatment cell...
Objective To investigate the efficacy of intraperitoneal GYY4137 therapy and intratesticular to testicular ischemia reperfusion injury in an experimental rat model. Methods 4 groups were set up as sham-operation group (group A), torsion/detorsion (T/D) B), plus (G-IP) C), (G-IT) D). Group A was control group. In order form a T/D model, left testis operated rotation reached 720 degrees clockwise which lasted 1 hour before B, C D. accepted 100 μmol/kg intraperitoneally half after...
Objective To evaluate efficacy and safety of retrograde intrarenal stone surgery for treatment upper urinary calculi. Methods The clinical data 640 patients with tract calculi treated by (RIRS) in Renmin Hospital Wuhan University from April 2016 to January 2019 were retrospectively analyzed. There 424 males 216 females. The awerage age was (46.2±12.8) years old, ranging 18 76 old. maximum diameter the is (1.4±0.7) cm, 0.6-3.2 cm. 126 cases inferior 514 non-lurgical calculi. 196...