A5100417262- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Genetics and Neurodevelopmental Disorders
- Glioma Diagnosis and Treatment
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Inflammasome and immune disorders
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Ischemia and Reperfusion
- Neurogenesis and neuroplasticity mechanisms
- Cancer Research and Treatments
- Neonatal Health and Biochemistry
- Ferroptosis and cancer prognosis
- Porphyrin and Phthalocyanine Chemistry
- Hepatitis B Virus Studies
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- CRISPR and Genetic Engineering
- Histone Deacetylase Inhibitors Research
- Hepatitis C virus research
- Cancer, Hypoxia, and Metabolism
Wuhan University
2012-2024
Renmin Hospital of Wuhan University
2017-2024
Liaocheng University
2024
Shaanxi Provincial People's Hospital
2024
Zhongnan Hospital of Wuhan University
2022-2023
Tianjin Medical University
2023
Shanghai Tenth People's Hospital
2023
Sichuan University
2022
West China Hospital of Sichuan University
2022
Frontier Science Foundation
2022
Abstract The purpose of this study was to investigate whether inhibition DNA (cytosine-5)-methyltransferase 1 (DNMT-1) alleviated ferroptosis through nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy during diabetes myocardial (DM) ischemia/reperfusion (I/R) injury (IRI). Rat DM + sham (DS), I/R, and I/R (DIR), H9c2 cell high glucose (HG), hypoxia reoxygenation (H/R), high-glucose (HH/R) models were established. DNMT-1 inhibitor 5-Aza-2’-deoxycytidine (5-aza-CdR) administered...
This study sought to identify patients with repaired tetralogy of Fallot (rTOF) at high risk death and malignant ventricular arrhythmia (VA).To date there is no robust stratification scheme predict outcomes in adults rTOF.Consecutive were prospectively recruited for late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) define right left (RV, LV) fibrosis addition proven markers.The primary endpoint was all-cause mortality. Of the 550 (median age 32 years, 56% male), 27...
The mechanisms involved in the anabolic effect of interferon gamma (IFNγ) on bone have not been carefully examined. Using microarray expression analysis, we found that IFNγ upregulates a set genes associated with tryptophan degradation pathway, known as kynurenine osteogenic differentiating human mesenchymal stem cells (hMSC). We, therefore, hypothesized activation pathway plays role osteoblastogenesis even absence IFNγ. Initially, observed strong increase during and without media. We next...
CRISPR Cas13a provided a robust, simple and fluorescence-based method for m 1 A detection dynamic demethylation analysis of 28S rRNA.
X-ray detection is widely utilized in our daily life, such as medical diagnosis, security checking, and environmental monitoring. However, most of the commercial detectors are based on inorganic semiconductors, e.g., Si, CdTe, Ge, which require complex costly fabrication processes. Metal halide perovskites have recently emerged a set promising candidates for ionizing radiation detection, owing to high attenuation coefficient, long carrier lifetime, excellent charge transport properties....
The mechanisms underlying spatial and temporal control of cortical neurogenesis the brain are largely elusive. Long non-coding RNAs (lncRNAs) have emerged as essential cell fate regulators. Here we found LncKdm2b (also known Kancr), a lncRNA divergently transcribed from bidirectional promoter Kdm2b, is transiently expressed during early differentiation projection neurons. Interestingly, Kdm2b's transcription positively regulated in cis by LncKdm2b, which has intrinsic-activating function...
Aims . Ischemic postconditioning (IPO) has a strong protective effect against intestinal ischemia-reperfusion (IIR) injury that is partly related to autophagy. However, the precise mechanisms involved are unknown. Methods C57BL/6J mice were subjected unilateral IIR with or without IPO. After 45 min ischemia and 120 reperfusion, tissues blood collected for examination. HE staining Chiu’s score used evaluate pathologic injury. We test markers of barrier function oxidative stress. Finally, we...
Background and Aim: The global pandemic of COVID-19 has posed an enormous threat to the economy people's lives across various countries. Patients with most commonly present respiratory symptoms. However, gastrointestinal (GI) symptoms can also occur. We aimed study relationship between GI disease prognosis in patients COVID-19. Methods: In a single-center retrospective cohort study, outcomes or without were compared. propensity score is conditional probability having particular exposure...
Glioblastoma multiforme (GBM) is a highly invasive brain tumor with limited therapeutic means and poor prognosis. Recent studies indicate that glioma-initiating cells/glioma stem cells (GICs/GSCs) may be responsible for initiation, infiltration, recurrence. GICs could aberrantly employ molecular machinery balancing self-renewal differentiation of embryonic neural precursors. Here, we find paired related homeobox 1 (PRRX1), homeodomain transcription factor was previously reported to control...
Exopolysaccharide (EPS) was produced by Lacticaseibacillus paracasei ZY-1 isolated from Tibetan kefir grains, and the preliminary structure of two EPS fractions (EPS1 EPS2) investigated. NMR analysis revealed that backbone higher producing EPS1 consisted →6)-α-D-Manp-(1→, →2,6)-α-D-Glcp-(1→, α-D-Manp-(1→, →2)-α-D-Glcp-(1→, →3)-α-D-Manp-(1→, →6)-α-D-Glcp-(1→. Furthermore, an eps gene cluster encodes glycosyltransferase relevant proteins for biosynthesis identified on basis bioinformation...
β-catenin-dependent canonical Wnt signaling plays a plethora of roles in neocortex (Ncx) development, but its function regulating the abundance intermediate progenitors (IPs) is elusive. Here we identified neCtnnb1, an evolutionarily conserved cis-regulatory element with typical enhancer features developing Ncx. neCtnnb1 locates 55 kilobase upstream and spatially close to promoter Ctnnb1, gene encoding β-catenin. CRISPR/Cas9-mediated activation or interference locus enhanced inhibited...
Less quantity of transplanted mesenchymal stem cells (MSCs) influences the therapeutic effects on radiation-induced lung injury (RILI). Previous studies have demonstrated that MSCs overexpressing Chemokine (C-X-C motif) receptor 4 (CXCR4) could increase to local tissues. In present study, we conducted CXCR4 human umbilical cord cell (HUMSC) therapy for RILI. C57BL mice received single dose thoracic irradiation with 13 Gy X-rays and then were administered saline, control HUMSCs, or...
Increasing evidence shows that the abnormal long non-coding RNAs (lncRNAs) expression is closely related to ischemia-reperfusion injury (I/R) progression. Studies have previously described lncRNA MEG3 regulates pyroptosis in various organs I/R. Nevertheless, mechanisms of testicular I/R has not been clarified. The aim this research unravel underlying regulation mediated by during We established a torsion/detorsion (T/D) model and an oxygen-glucose deprivation/reperfusion (OGD/R)-treated...
Background: Cell models are key instruments for in vitro studies of the thyroid. Permanent thyroid cell lines that widely used laboratory research typically originate from tumors. For many purposes, it is desirable to compare tumor cells with originating normal tissue. However, such cultures grow slowly, have a highly limited life-span, and known lose their characteristics. The aim present study was type coding noncoding markers different culture systems an attempt determine optimal...
The management of glioblastomas (GBMs) is challenged by the development therapeutic resistance and early disease recurrence, despite multi-modal therapy. This may be attributed to presence glioma stem cells (GSCs) which are known survive radio- chemotherapy, circumventing death signals inducing cell re-population. Recent findings suggest GSCs enriched certain treatment modality. These necessitate novel therapeutics capable targeting GBM plasticity therapy-resistant GSCs. Here, aided...
FT-IR, FT-Raman and electronic absorption spectroscopies were utilized in conjunction with density functional theory (DFT) calculations to investigate the ground excited states of self-assembled dinuclear dimeric helicates (ZnL)2 (NiL)2 [L = bis(2,4-dimethyldipyrrin-3-yl)methane]. These studies afford a detailed description ground-state geometric structures provide comparison similar geometrical metal-porphyrins. The results demonstrate that enlarging basis set used DFT an obvious alteration...
Diabetic nephropathy (DN) is characterized by excessive accumulation of extracellular matrix leading to early thickening glomerular and tubular basement membrane. C1q/tumor necrosis factor (TNF)-related protein-9 (CTRP9) was recently identified as an adiponectin paralog superior prominence. CTRP9 anti-inflammatory, antioxidant, vasodilation atheroprotective adipose cytokine that share a similar metabolic regulatory function adiponectin. Additionally, inhibits apoptosis endothelial cells,...
The hippocampus plays major roles in learning and memory, its formation requires precise coordination of patterning, cell proliferation, differentiation, migration. Here we removed the chromatin-association capability KDM2B progenitors developing dorsal telencephalon (Kdm2b∆CxxC) to discover that Kdm2b∆CxxC hippocampus, particularly dentate gyrus, became drastically smaller with disorganized cellular components structure. mice display prominent defects spatial motor fear conditioning,...