A5028649204- Ferroptosis and cancer prognosis
- Cancer-related Molecular Pathways
- PI3K/AKT/mTOR signaling in cancer
- Cholesterol and Lipid Metabolism
- Kidney Stones and Urolithiasis Treatments
- Cancer, Lipids, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Cancer Immunotherapy and Biomarkers
- Protein Tyrosine Phosphatases
- Microtubule and mitosis dynamics
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Polyamine Metabolism and Applications
- Chronic Kidney Disease and Diabetes
- Parathyroid Disorders and Treatments
- Mast cells and histamine
Wuhan University
2023-2024
Renmin Hospital of Wuhan University
2023-2024
Abstract Background Bladder cancer (BC) is the most common urinary tract malignancy. Aurora kinase B (AURKB), a component of chromosomal passenger protein complex, affects segregation during cell division. Mitotic arrest-deficient 2-like 2 (MAD2L2) interacts with various proteins and contributes to genomic integrity. Both AURKB MAD2L2 are overexpressed in human cancers have synergistic oncogenic effects; therefore, they regarded as emerging therapeutic targets for cancer. However,...
Although combination chemotherapy is widely used for bladder cancer (BC) treatment, the recurrence and progression rates remain high. Therefore, novel therapeutic targets are required. Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) contributes to tumourigenesis immune evasion in several cancers; however, its biological function BC remains unknown. This study aimed investigate expression, prognostic value protumoural of MTHFD2 elucidate mechanism programmed death-ligand 1 (PD-L1)...
Abstract Bladder cancer (BCa) is one of the most common malignancies worldwide. However, lack accurate and effective targeted drugs has become a major problem in current clinical treatment BCa. Studies have demonstrated that squalene epoxidase (SQLE), as key rate-limiting enzyme cholesterol biosynthesis, involved development. In this study, our analysis The Cancer Genome Atlas, Genotype-Tissue Expression, Gene Expression Omnibus databases showed SQLE expression was significantly higher...
The increased activity of the mTOR pathway in bladder cancer has been extensively studied, but no satisfactory inhibitor found cancer. role AZD8055, a second-generation inhibitor, not reported Herein, we investigated effects AZD8055 on cells and their interaction with macrophages vivo vitro. In four cell lines, phosphorylation mTOR, AKT S6K1 was suppressed by AZD8055. inhibited proliferation induced G1 cell-cycle arrest apoptosis concentration-dependent manner. also inhibits migration...