A5100656917- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Renal and Vascular Pathologies
- MRI in cancer diagnosis
- Parathyroid Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Renal Diseases and Glomerulopathies
- Chemotherapy-induced organ toxicity mitigation
- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- Magnesium in Health and Disease
- Vitamin D Research Studies
- Multiple Myeloma Research and Treatments
- Pain Mechanisms and Treatments
- Cancer-related gene regulation
- Inflammasome and immune disorders
- Heterotopic Ossification and Related Conditions
- Calpain Protease Function and Regulation
- Peptidase Inhibition and Analysis
- Immunodeficiency and Autoimmune Disorders
- Uterine Myomas and Treatments
- Abdominal vascular conditions and treatments
- Connective tissue disorders research
- Cardiac Valve Diseases and Treatments
- Osteoarthritis Treatment and Mechanisms
Guangdong Provincial People's Hospital
2022-2025
Liaocheng University
2024
Ningbo University
2024
Qilu Hospital of Shandong University
2024
Shanghai Zhabei District Shibei Hospital
2023
Renji Hospital
1993-2022
Shanghai Jiao Tong University
2015-2022
First Affiliated Hospital of Anhui Medical University
2016-2019
Anhui Medical University
2016-2019
Shanghai Ninth People's Hospital
2018
Cisplatin is a widely used chemotherapeutic drug in the treatment of various solid tumors. However, cisplatin-induced acute kidney injury remains disturbing complication, which still lacks effective prevention. Cisplatin-induced oxidative damage and mitochondrial dysfunction are anticipated to be crucial occurrence injury. Astragalus polysaccharide (APS) has been reported possess multiple biological activities including anti-inflammatory, antioxidant, mitochondria protection. In this study,...
Kidney injury molecule-1 (KIM-1) is highly expressed in renal tubular cells after and usually regarded as an early biomarker of acute kidney injury(AKI). The aim this study was to determine the role KIM-1 development Methods: Clinical samples, three different animal models vitro experiments were utilized possible mechanism underlying involvement injury.Both plasma urinary expression levels significantly higher AKI chronic disease (CKD) patients than healthy volunteers, CKD patients....
Nephrotoxicity remains a serious adverse effect of cisplatin chemotherapy, limiting its clinical usage. Numerous studies show that oxidative stress and inflammation are closely associated with cisplatin-induced renal damage. Astragaloside IV (AS-IV) has been found to possess antioxidant anti-inflammation functions. Therefore, we investigated the potential curative effects AS-IV against injury possible cellular mechanism for activity, both in vitro vivo. We pretreatment HK-2 cells could...
Abstract Glomerulonephritis is the one of major causes end‐stage kidney disease, whereas pathological process glomerulonephritis still not completely understood. Single‐cell RNA sequencing (scRNA‐seq) emerges to be a powerful tool evaluate full heterogeneity diseases. To reveal cellular gene expression profiles glomerulonephritis, we performed scRNA‐seq 2 human transplantation donor samples, 4 1 malignant hypertension (MH) sample and chronic interstitial nephritis (CIN) sample, all tissues...
Abstract Background We proposed an artificial intelligence-based immune index, Deep-immune score, quantifying the infiltration of cells interacting with tumor stroma in hematoxylin and eosin-stained whole-slide images colorectal cancer. Methods A total 1010 cancer patients from three centers were enrolled this retrospective study, divided into a primary (N = 544) validation cohort 466). which reflected both proportion region. further analyzed correlation between score CD3 + T density region...
Background As an indispensable marker of complement cascades activation, C4d was confirmed its crucial role in the pathogenesis both lupus nephritis (LN) and IgA nephropathy (IgAN). While studies directly comparing diagnostic value, outcomes predicting function between LN IgAN are still absent. Methods A cohort 120 patients, patients who were diagnosed by renal biopsy January 2015 December 2017 24 healthy age matched controls prospectively analyzed. The followed till 2020. adverse disease...
To assess the severity of renal pathology in patients with chronic kidney disease (CKD) using contrast-enhanced ultrasonography (US).275 CKD who were proven by biopsy and 30 healthy adults examined conventional US US. Ultrasonic parameters included length, cortical thickness, rise time (RT), peak intensity (PI), area under time-intensity curve (AUC), wash-in slope (WIS) to (TTP). Based on pathological scores, classified into mild, moderate severe groups. The logistic regression analysis...
Abstract: Transcatheter aortic valve replacement (TAVR) has been recently indicated for the treatment of patients with severe stenosis in all risk profiles. At present, TAVR become mature at home and abroad, but relevant experience is deficient outflow tract stenosis. One case a high-risk surgical patient was included this paper who suffered from left ventricular (LVOT) In case, performed deep implantation new both LVOT were treated through single procedure. This highlights vital role such...
Abstract Renal osteodystrophy (ROD) occurs as early chronic kidney disease (CKD) stage 2 and seems ubiquitous in almost all pediatric patients with CKD 5. Fibroblast growth factor (FGF)-23, a bone-derived endocrine regulator of phosphate homeostasis, is overexpressed disturbs osteoblast differentiation matrix mineralization. In contrast, C-type natriuretic peptide (CNP) acts potent positive bone growth. the present study, we infused CNP into uremic rats observed whether could attenuate ROD...
The factors influencing the prognosis of acute kidney injury (AKI) were analyzed in a group elderly AKI patients to determine markers early prognosis.A total 258 screened, and 201 enrolled study. Eventually, 184 included study, including 79 (≥60 years old). During one year follow-up, renal function changes observed, risk that influenced analyzed.When occurred, urine molecule-1 (uKIM-1) level was significantly higher progressive deterioration than stable group. ROC curve analysis revealed...
Inflammation might be one of the essential underlying mechanisms renal fibrosis, which is considered a key pathological feature end-stage disease and closely associated with proteinuria decreased function. Apoptosis-associated speck-like protein containing CARD (ASC), identified as central structure inflammasome, involved in progression interstitial fibrosis; however, its signal transduction pathways remain unclear. In present study, we performed unilateral ureter obstruction (UUO) both...
The purpose of the present study was to determine whether fibroblast growth factor (FGF)‑23 could serve as a novel biomarker for renal osteodystrophy (ROD) progression. A rat model ROD induced by left nephrectomy plus intravenous injection Adriamycin. Serum FGF‑23 determined using an enzyme‑linked immunosorbent assay. level and bone expression were both significantly elevated in group at 24 h post‑surgery. negatively correlated with calcium, phosphate, 25‑hydroxyvitamin D, conventional...
Background: Shear wave elastography ultrasound (SWE) is an emerging non-invasive candidate for assessing kidney stiffness. However, its prognostic value regarding injury unclear. Methods: A prospective cohort was created from biopsy patients in our hospital May 2019 to June 2020. The primary outcome the initiation of renal replacement therapy or death, while secondary eGFR < 60 mL/min/1.73 m2. Ultrasound, biochemical, and examinations were performed on same day. Radiomics signatures...
This study examines whether clot patterns at large artery occlusion sites, as observed using digital subtraction angiography (DSA) and computed tomography (CTA), can reliably indicate intracranial atherosclerotic stenosis (ICAS) in acute ischemic stroke (AIS) patients.
Background: Although multiple myeloma is still incurable, an abundance of novel treatments have become available for relapsed and or refractory (RRMM). Direct head-to-head comparisons between the are lacking. We performed a network meta-analysis to evaluate immediate effects such as response quality current novel-drugs combined therapeutic regimens, with aim identify that could be more effective than others in RRMM.Methods: searched Cochrane Library, PubMed, Embase, Web Science randomized...
C-type natriuretic peptide (CNP) is believed to be produced locally in the kidneys and possess several renoprotective properties. In contrast, fibroblast growth factor (FGF) -23 elevates early stage of chronic kidney disease predicts its outcomes. Currently, studies have demonstrated that CNP FGF-23 act through a close pathway, moreover, FGF-23/mitogen-activated protein kinase (MAPK) can obviously suppressed by CNP. present study, human mesangial cells (MCs) were incubated serum-containing...
e17007 Background: AML is commonly diagnosed in elderly patients, who are usually not candidates for intensive induction chemotherapy. Azacytidine (AZA) has been FDA approved MDS, its activity reported but upfront treatment prospectively studied. This study aims to analyze the characteristics and outcome of such MMC. Methods: A chart review was performed on all patients between January 2005 December 2008 Patients were eligible if age > 60, bone marrow blast counts 20%, naive. Results: Six...