A5055306575- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and biological activity
- Catalytic C–H Functionalization Methods
- Chemical Reactions and Isotopes
- Protein Degradation and Inhibitors
- Click Chemistry and Applications
- Peptidase Inhibition and Analysis
- Streptococcal Infections and Treatments
- Synthesis and Biological Evaluation
- Computational Drug Discovery Methods
- Ubiquitin and proteasome pathways
- Spine and Intervertebral Disc Pathology
- Cancer therapeutics and mechanisms
- Pharmacogenetics and Drug Metabolism
- HIV/AIDS drug development and treatment
- Quinazolinone synthesis and applications
- Radical Photochemical Reactions
- Metal-Organic Frameworks: Synthesis and Applications
- Metastasis and carcinoma case studies
- Scoliosis diagnosis and treatment
- Histone Deacetylase Inhibitors Research
- Antimicrobial Resistance in Staphylococcus
- Medical Imaging and Analysis
- Synthetic Organic Chemistry Methods
Zhengzhou University
2018-2025
Zhengzhou Children's Hospital
2022-2025
Henan University of Science and Technology
2023-2025
Peking University
2025
Beijing Shijingshan Hospital
2022-2024
Capital Medical University
2022-2024
PLA Rocket Force University of Engineering
2023-2024
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2023-2024
Women's Hospital, School of Medicine, Zhejiang University
2024
Rutgers, The State University of New Jersey
2023
The major drawbacks of P-glycoprotein (P-gp) inhibitors at the clinical stage make development new P-gp challenging and desirable. In this study, we reported our structure-activity relationship studies 4-indolyl quinazoline, which led to discovery a highly effective orally active inhibitor, YS-370. YS-370 effectively reversed multidrug resistance (MDR) paclitaxel colchicine in SW620/AD300 HEK293T-ABCB1 cells. bound directly P-gp, did not alter expression or subcellular localization cells,...
An efficient synthesis of a variety 3-alkyl quinoxalinones via C-H direct alkylation by photoredox catalysis between and alkylborates is reported. A range was tolerated well. This visible-light photocatalysis reaction allows access to structurally diverse in good excellent yields. The practicality this protocol demonstrated the concise potential bioactive nonpeptide angiotensin II receptor antagonist.
Two ingenane- (1 and 2), two ent-atisane- (3 4), ent-kaurane- (5 6), ent-abietane- (7 8), one ent-isopimarane-type (9) diterpenoid 12 known analogues have been isolated from the methanolic extract of stems Euphorbia royleana. Their structures, including absolute configurations, were determined by extensive spectroscopic methods ECD data analysis. The nitric oxide inhibitory activities those diterpenoids examined biologically in lipopolysaccharide-stimulated BV-2 cells, with compounds 1, 2,...
Multiple myeloma (MM) is a plasma cell malignancy of bone marrow. In the present study, we aimed to study function and potential mechanism antisense non-coding RNA in INK4 Locus (ANRIL) MM. The expression levels ANRIL MM patients healthy donors were evaluated by quantitative real-time polymerase chain reaction (qRT-PCR). effects mechanisms viability assay, BrdU incorporation tumor xenograft model, flow cytometry, western blot, immunoprecipitation (RIP), transcriptome sequencing, chromatin...
Streptococcus suis, a zoonotic pathogen, is commonly found as commensal bacterium in the respiratory tracts of pigs. Under specific conditions, it becomes invasive and enters blood, causing severe systemic infections. For S. effective acquisition carbon sources different host niches necessary for its survival. However, now, our understanding metabolism suis within highly restricted. Pyruvate formate lyase (PFL) plays crucial role bacterial survival glucose-limited hypoxic tissues. Here, we...