A5055192122- stochastic dynamics and bifurcation
- Neural dynamics and brain function
- Nonlinear Dynamics and Pattern Formation
- Neuroscience of respiration and sleep
- Photoreceptor and optogenetics research
- Chaos control and synchronization
- Neuroscience and Neuropharmacology Research
- Quantum chaos and dynamical systems
- Neural Networks Stability and Synchronization
- EEG and Brain-Computer Interfaces
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Gene Regulatory Network Analysis
- Advanced Memory and Neural Computing
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Neuroendocrine regulation and behavior
- Nonlinear Photonic Systems
- Pediatric Pain Management Techniques
- Cytokine Signaling Pathways and Interactions
- Ecosystem dynamics and resilience
- Ultrasound and Hyperthermia Applications
- Liver physiology and pathology
- Hydrogels: synthesis, properties, applications
- Liver Disease Diagnosis and Treatment
North China University of Technology
2015-2024
Guangxi Medical University
2021-2024
People's Hospital of Xinjiang Uygur Autonomous Region
2024
Shanghai Tenth People's Hospital
2021-2022
Tongji University
2021-2022
First Affiliated Hospital of GuangXi Medical University
2021
Tumor Hospital of Guangxi Medical University
2020
The University of Texas at Arlington
2013
Jiangsu University
2011
Academy of Mathematics and Systems Science
2007-2008
Abstract Genetically arming new chimeric antigen receptors (CARs) on T cells is a prevalent method to fulfill CAR‐T immunotherapy. However, this approach fails completely address the poor infiltration, complex immunosuppressive tumor microenvironment (ITM), and insufficient immune cells, which are recognized as three dominant hurdles discouraging trafficking persistence of checkpoint blockade (ICB) immunotherapies against solid tumors. To hurdles, sonoimmunity‐engineered nanoplatform...
Intratumoral or intestinal microbiota correlates with tumorigenesis and progression, regulation for reinforcing various anti-tumor approaches is of significant importance, which, however, suffers from no precise method unclear underlying mechanism. Herein, a microbiome metabolism-engineered phototherapy strategy established, wherein Nb
Emerging evidence has shown the role of mesenchymal stem cell-derived exosome (MSC-exo) in inducing resistance cancer cells to chemotherapy. However, it remains unclear whether change MSC-exo response chemotherapy also contributes chemoresistance. In this study, we investigated effect a standard-of-care chemotherapeutic agent, doxorubicin (Dox), on and its contribution development Dox breast (BCs). We found that secreted by Dox-treated MSCs (Dt-MSC-exo) induced higher degree BCs when...
Abstract Purpose: Sorafenib and erlotinib are potent, orally administered receptor tyrosine kinase inhibitors with antiproliferative antiangiogenic activities. Given their inhibitory target profile efficacy as single agents, the combination of these drugs is considerable interest in solid malignancies. This study aimed to determine recommended phase II dose this targeted combination, toxicity profile, pharmacokinetic interaction, preliminary clinical Experimental Design: was alone for a...
Hepatocellular carcinoma (HCC) usually occurs at the late stage of chronic liver injury. Oncostatin M (OSM) is a tumor-associated cytokine highly expressed in cirrhosis and HCC patients; however, its role hepatocarcinogenesis has not been clearly elucidated. In this study, we investigated effect OSM on occurrence rat model N-diethylnitrosamine-induced HCC. overexpression significantly increased number tumor nodules shortened overall survival rats. Notably, promoted HPC activation vivo but...
Obesity is associated with an increased risk of tumorigenesis, and leptin levels can promote tumor metastasis. However, the effects on bone metastasis in breast cancer are not fully understood. Here, we examined receptor expression tissue samples from 96 patients. In addition, investigated metastatic capacity cells invitro using a transwell assays. The results indicated that higher incidence Additionally, promoted migration invasion cells. SDF-1/CXCR4 axis activated by also cancer. Finally,...
Hepatic fibrosis arises from a sustained wound-healing response to chronic liver injury. Because the occurrence and development of hepatic is always associated with inflammation, controlling inflammation within may be an effective means progression fibrosis.Aspirin non-steroidal anti-inflammatory drug used relieve both inflammatory symptoms pain.The results our study showed that aspirin significantly attenuated effectively inhibited activation proliferation stellate cells (HSCs), which led...
Abstract Background Mesenchymal stem cells (MSCs) play a crucial role in cancer development and tumor resistance to therapy prostate cancer, but the influence of MSCs on stemness potential PCa by cell–cell contact remains unclear. In this study, we investigated effect direct with its mechanisms. Methods First, flow cytometry, colony formation, sphere formation were performed determine , expression stemness-related molecules (Sox2, Oct4, Nanog) was western blot analysis. Then, used qPCR...