A5000979761- stochastic dynamics and bifurcation
- Neural dynamics and brain function
- Nonlinear Dynamics and Pattern Formation
- Gene Regulatory Network Analysis
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Evolution and Genetic Dynamics
- Neural Networks Stability and Synchronization
- RNA Research and Splicing
- Parkinson's Disease Mechanisms and Treatments
- Bacterial Genetics and Biotechnology
- Chaos control and synchronization
- Microtubule and mitosis dynamics
- Advanced Thermodynamics and Statistical Mechanics
- Autophagy in Disease and Therapy
- Ecosystem dynamics and resilience
- Receptor Mechanisms and Signaling
- Molecular Communication and Nanonetworks
- Cancer-related Molecular Pathways
- Lysosomal Storage Disorders Research
- DNA and Nucleic Acid Chemistry
- Cholinesterase and Neurodegenerative Diseases
- Solid-state spectroscopy and crystallography
- Single-cell and spatial transcriptomics
- Genetics, Aging, and Longevity in Model Organisms
Beihang University
2015-2024
The University of Texas at Arlington
2013
Based on actual neuronal firing activities, bursting in the Chay model is considered, which V K, reversal potentials for K+, C, Ca2+, time kinetic constant λ n and an additional depolarized current I are considered as dynamical parameters. According to number of Hopf bifurcation points upper branch curve fast subsystem, associated with stable limit cycle corresponding spiking states, different types their respective behavior surveyed by means fast-slow analysis.
Accumulation of the misfolded synaptic protein α-synuclein (αSyn*) is a hallmark neurodegenerative disease in Parkinson's (PD). Recent studies suggest that autophagy lysosome pathway (ALP) including both Beclin1-associated and mTOR-signaling pathways involved αSyn* clearance mechanism. In this study, mathematical model proposed for degradation by ALP with crosstalk element mTOR. Using codimension-1 bifurcation analysis, tri-stability surveyed under three different stress signals and,...
Long-term potentiation (LTP) is a specific form of activity-dependent synaptic plasticity that leading mechanism learning and memory in mammals. The properties cooperativity, input specificity, associativity are essential for LTP; however, the underlying mechanisms unclear. Here, based on experimentally observed phenomena, we introduce computational model pyramidal cell to explore responsible LTP. molecular processes involved integrates gene expression regulation neuronal activity. In model,...
Gaussian white noise (GWN), as an intrinsic source, can give rise to various firing activities at the rest state before a supercritical or subcritical Hopf bifurcation (supH subH) in Chay system without with external current input, when V K , C λ n and I are considered changeable control parameters. These closely related global mechanism of whole fast/slow dynamical subsystems, be tackled by means analysis. GWN induce some typical bursting phenomena stochastic system. Firstly, integer...
The dynamics of p53 play important roles in the regulation cell fate decisions response to various stresses, and programmed death 5 (PDCD5) functions as a co-activator that modulates dynamics. In present paper, we investigated how are modulated by PDCD5 during deoxyribose nucleic acid damage using methods bifurcation analysis potential landscape. Our results revealed activities display rich under different levels, including monostability, bistability with two stable steady states,...
A compositive pancreatic β-cells model is developed by focusing on two important slow negative feedback mechanisms, where three processes C ss , er and a with different time scales can interact to drive fast, medium electrical bursting typically observed in β-cells. We found that diverse patterns of shapes varying from only waves the coexistence spikes spikes, which are robust oscillation periods. Therefore, dynamic bifurcation mechanisms these could be surveyed fast/slow analysis fast...
A large optofluidic compound eye is developed by using a straightforward, rapid, and low-cost technique. The eye's angle of view can be adjusted injecting deionized water/calcium chloride solution different volume into the chip. Optofluidic eyes containing about 78,000 microlenses 50 μm diameter are fabricated for analysis. tuned up to 104°. With deformation, microlenses' focal length increases, due variation in profile. Owing non-uniform strain over eye, central lenses experience more...