A5029030472- Circadian rhythm and melatonin
- Spaceflight effects on biology
- Light effects on plants
- Sleep and Work-Related Fatigue
- Sleep and related disorders
- RNA and protein synthesis mechanisms
- Photosynthetic Processes and Mechanisms
- RNA modifications and cancer
- RNA Research and Splicing
- Genetics, Aging, and Longevity in Model Organisms
- Fungal and yeast genetics research
- Plant Molecular Biology Research
- Genomics and Chromatin Dynamics
- Endoplasmic Reticulum Stress and Disease
- Genomics and Phylogenetic Studies
- Protist diversity and phylogeny
- Autophagy in Disease and Therapy
- High Altitude and Hypoxia
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Polyamine Metabolism and Applications
- Lipid metabolism and biosynthesis
- Protein Kinase Regulation and GTPase Signaling
- Gene expression and cancer classification
- Plant and Biological Electrophysiology Studies
Sun Yat-sen University
2015-2025
Shuguang Hospital
2023
Shanghai University of Traditional Chinese Medicine
2023
Wuhan University of Technology
2020
State Council of the People's Republic of China
2020
Shanghai East Hospital
2014
The University of Texas Southwestern Medical Center
2007-2013
Southwestern Medical Center
2013
Fudan University
2002-2007
State Key Laboratory of Genetic Engineering
2003-2007
Space charge layer model at the Pt anode/BZY10 proton conductor interface.
FREQUENCY (FRQ) is the central component of Neurospora circadian clock. All FRQ proteins form FFC complex with FRH (FRQ-interacting RNA helicase) that acts as negative element in feedback loop by repressing frq mRNA levels. To understand function FRQ-FRH interaction, we mapped and identified minimal region required for interaction. We demonstrated formation interaction between White Collar Complex (WCC) clock function. On other hand, complex, also FRH-WCC Disruption or down-regulation...
Peptidylarginine deiminase IV (PADI4) is widely distributed in several tissues and the expression correlated with many pathological processes. Chemotherapy remains a major treatment alternatively to surgery for large number of patients at advanced stage hepatocellular carcinoma (HCC). However, role PADI4 chemoresistance HCC has not been identified.MTT PI/Annexin V assay were employed examine proliferation apoptosis cell lines. The MDR1 detected by Realtime PCR. GFP tagged LC3 vector electron...
Circadian clocks are evolved to adapt the daily environmental changes under different conditions. The ability maintain circadian clock functions in response various stresses and perturbations is important for organismal fitness. Here, we show that nutrient-sensing GCN2 signaling pathway required robust function amino acid starvation Neurospora . deletion of components disrupts rhythmic transcription gene frq by suppressing WC complex binding at promoter due its reduced histone H3 acetylation...
Circadian clocks drive a large array of physiological and behavioral activities. At the molecular level, circadian are composed positive negative elements that form core oscillators generating basic rhythms. Over course period, proteins undergo progressive hyperphosphorylation eventually degrade, their stability is finely controlled by complex post-translational pathways, including protein modifications, genetic codon preference, protein–protein interactions, chaperon-dependent conformation...
<i>Objectives:</i> Previous data has reported similarity between human brain and testis gene expression patterns. Brain is the most important tissue in speciation. Hence, it means that could also play a crucial role speciation if these two tissues exhibit similar However, previous reports were based on only limited scattered data. Determining large scale anatomy of patterns various draw more convincing conclusion, better our understanding correlation/inter-correlation among...
Many aspects of energy metabolism, including glucose and lipid homeostasis mitochondrial oxidative are under precise control by the mammalian circadian clock. However, molecular mechanism for coordinate integration clock various metabolic pathways is poorly understood. Here we show that BAF60a, a chromatin-remodeling complex subunit, rhythmically expressed in liver mice. Mice with liver-specific knockdown BAF60a abnormalities rhythmic expression pattern genes circulating metabolite profile....
Environmental factors in space are dramatically different from those on Earth. The spaceflight environment has been known to influence human physiology and behavior orbital missions. In this study, we investigated alterations the diurnal rhythms of activity heart rate three Chinese astronauts a mission. An analysis data showed significant decrease amplitudes during flight all subjects. were significantly dampened flight, minimum as well maximum value increased after flight. A phase shift was...
Here, we report the identification of a novel domain – GG (domain in KIAA1199, FAM3, POMGnT1 and Tmem2 proteins, with two well‐conserved glycine residues), present eukaryotic FAM3 superfamily (FAM3A, FAM3B, FAM3C FAM3D), (protein O‐linked mannose β‐1,2‐ N ‐acetylglucosaminyltransferase), TEM2 proteins as well phage gp35 proteins. has been revealed to be implicated muscle–eye–brain disease non‐syndromic hearing loss. The presence Bacteriophage hinge connector long tail fiber might reflect...
We previously revealed similarity in gene expression patterns between human brain and testis, based on digital differential display analyses of 760 Unigenes. In the present work, we reanalyzed data many tissues mouse for a large number genes almost covering respective whole genomes. The results indicated that both mouse, profiles exhibited by brain, cerebellum testis are most similar to each other compared with tissues.
Most organisms on Earth possess circadian rhythms in their physiology and behaviors that allow them to resonate with the cycling environment over a 24-h period. However, human society, substantial quantity of jobs requires non–24-h working rest or shift schedules, which causes more less misalignment disorders as consequence. In this work, we conducted sleep deprivation (SD) schedule (8 h 4 off) experiment 10 d total measured changes series physiologic cognitive parameters. The results show...
The 1-Acylglycerolphosphate acyltransferase is crucial enzyme for synthesis of glycerolipids as well triacylglylcerol biosynthesis in eukaryotes. Six members 1-acyl-sn-glycerol-3-phosphate family human have been described, which were AGPAT1, 2, 3, 4, 5 and 6. Here we report the cloning characterization another novel member AGPAT7 (1-acyl-sn-glycerol-3-phosphate 7) gene, was mapped to chromosome 15q14. cDNA 1898 bp length, encoding a putative protein with 524 amino acid residues, contains an...
In spaceflight human circadian rhythms and sleep patterns are likely subject to change, which consequently disturbs physiology, cognitive abilities performance efficiency. However, the influence of microgravity on clock as well underlying mechanisms remain largely unknown. Placing volunteers in a prone position, whereby their heads rest at an angle -6° below horizontal, mimics environment orbital flight. Such positioning is termed head-down bed (HDBR). this work, we analysed 45-day HDBR...
The exosome is a complex with exoribonuclease activity that regulates RNA surveillance and turnover. also plays role in regulating the degradation of precursor mRNAs to maintain expression splicing variants. In Neurospora, silencing rrp44, which encodes catalytic subunit exosome, changed set spliceosomal snRNA, snRNP genes SR protein related genes. knockdown rrp44 affected assembly spliceosome. RNA-seq analysis revealed global change bulk events. Exosome-mediated may regulate alternative...
In space, circadian rhythms are prone to alteration. Head-down (–6°) bed rest (HDBR) is an approach simulating the weightlessness condition, which allows effects of on physiological variables be studied ground. this work, we analyzed changes in diurnal activity, sleep-wake cycles, and cardiovascular responses a 45-day HDBR. All subjects exhibited increased daytime sleep, whereas total sleep time was comparable. The results wrist activity monitoring showed significant reduction during HDBR...